Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7CH0

The overall structure of the MlaFEDB complex in ATP-bound EQclose conformation (Mutation of E170Q on MlaF)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005548	molecular_function	phospholipid transporter activity
A	0005886	cellular_component	plasma membrane
A	0015914	biological_process	phospholipid transport
A	0016020	cellular_component	membrane
A	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
A	0120010	biological_process	intermembrane phospholipid transfer
A	0120014	molecular_function	phospholipid transfer activity
A	1990531	cellular_component	phospholipid-translocating ATPase complex
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005886	cellular_component	plasma membrane
B	0015914	biological_process	phospholipid transport
B	0016020	cellular_component	membrane
B	0016887	molecular_function	ATP hydrolysis activity
B	0120010	biological_process	intermembrane phospholipid transfer
B	0120014	molecular_function	phospholipid transfer activity
B	1990531	cellular_component	phospholipid-translocating ATPase complex
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006974	biological_process	DNA damage response
C	0015914	biological_process	phospholipid transport
C	0016020	cellular_component	membrane
C	0046677	biological_process	response to antibiotic
C	0120010	biological_process	intermembrane phospholipid transfer
C	0120014	molecular_function	phospholipid transfer activity
C	1990531	cellular_component	phospholipid-translocating ATPase complex
D	0005515	molecular_function	protein binding
D	0005548	molecular_function	phospholipid transporter activity
D	0005886	cellular_component	plasma membrane
D	0015914	biological_process	phospholipid transport
D	0016020	cellular_component	membrane
D	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
D	0120010	biological_process	intermembrane phospholipid transfer
D	0120014	molecular_function	phospholipid transfer activity
D	1990531	cellular_component	phospholipid-translocating ATPase complex
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005886	cellular_component	plasma membrane
E	0015914	biological_process	phospholipid transport
E	0016020	cellular_component	membrane
E	0016887	molecular_function	ATP hydrolysis activity
E	0120010	biological_process	intermembrane phospholipid transfer
E	0120014	molecular_function	phospholipid transfer activity
E	1990531	cellular_component	phospholipid-translocating ATPase complex
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006974	biological_process	DNA damage response
F	0015914	biological_process	phospholipid transport
F	0016020	cellular_component	membrane
F	0046677	biological_process	response to antibiotic
F	0120010	biological_process	intermembrane phospholipid transfer
F	0120014	molecular_function	phospholipid transfer activity
F	1990531	cellular_component	phospholipid-translocating ATPase complex
G	0005515	molecular_function	protein binding
G	0005543	molecular_function	phospholipid binding
G	0005548	molecular_function	phospholipid transporter activity
G	0005886	cellular_component	plasma membrane
G	0015914	biological_process	phospholipid transport
G	0016020	cellular_component	membrane
G	0120010	biological_process	intermembrane phospholipid transfer
G	0120014	molecular_function	phospholipid transfer activity
G	1990531	cellular_component	phospholipid-translocating ATPase complex
H	0005515	molecular_function	protein binding
H	0005543	molecular_function	phospholipid binding
H	0005548	molecular_function	phospholipid transporter activity
H	0005886	cellular_component	plasma membrane
H	0015914	biological_process	phospholipid transport
H	0016020	cellular_component	membrane
H	0120010	biological_process	intermembrane phospholipid transfer
H	0120014	molecular_function	phospholipid transfer activity
H	1990531	cellular_component	phospholipid-translocating ATPase complex
I	0005515	molecular_function	protein binding
I	0005543	molecular_function	phospholipid binding
I	0005548	molecular_function	phospholipid transporter activity
I	0005886	cellular_component	plasma membrane
I	0015914	biological_process	phospholipid transport
I	0016020	cellular_component	membrane
I	0120010	biological_process	intermembrane phospholipid transfer
I	0120014	molecular_function	phospholipid transfer activity
I	1990531	cellular_component	phospholipid-translocating ATPase complex
J	0005515	molecular_function	protein binding
J	0005543	molecular_function	phospholipid binding
J	0005548	molecular_function	phospholipid transporter activity
J	0005886	cellular_component	plasma membrane
J	0015914	biological_process	phospholipid transport
J	0016020	cellular_component	membrane
J	0120010	biological_process	intermembrane phospholipid transfer
J	0120014	molecular_function	phospholipid transfer activity
J	1990531	cellular_component	phospholipid-translocating ATPase complex
K	0005515	molecular_function	protein binding
K	0005543	molecular_function	phospholipid binding
K	0005548	molecular_function	phospholipid transporter activity
K	0005886	cellular_component	plasma membrane
K	0015914	biological_process	phospholipid transport
K	0016020	cellular_component	membrane
K	0120010	biological_process	intermembrane phospholipid transfer
K	0120014	molecular_function	phospholipid transfer activity
K	1990531	cellular_component	phospholipid-translocating ATPase complex
L	0005515	molecular_function	protein binding
L	0005543	molecular_function	phospholipid binding
L	0005548	molecular_function	phospholipid transporter activity
L	0005886	cellular_component	plasma membrane
L	0015914	biological_process	phospholipid transport
L	0016020	cellular_component	membrane
L	0120010	biological_process	intermembrane phospholipid transfer
L	0120014	molecular_function	phospholipid transfer activity
L	1990531	cellular_component	phospholipid-translocating ATPase complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	binding site for residue ATP B 301

Chain	Residue
B	ARG18
E	SER143
E	GLU144
E	SER146
E	GLY147
E	GLY148
E	MET149
E	GLY174
B	SER43
B	GLY44
B	GLY46
B	LYS47
B	THR48
B	THR49
B	GLN170
B	HIS203

site_id	AC2
Number of Residues	16
Details	binding site for residue ATP E 301

Chain	Residue
B	SER143
B	GLU144
B	SER146
B	GLY147
B	GLY148
B	MET149
B	GLY174
E	ARG18
E	SER43
E	GLY44
E	GLY46
E	LYS47
E	THR48
E	THR49
E	GLN170
E	HIS203

Functional Information from PROSITE/UniProt

site_id	PS00211
Number of Residues	15
Details	ABC_TRANSPORTER_1 ABC transporters family signature. LSGGMARRAALARAI

Chain	Residue	Details
B	LEU145-ILE159

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	36
Details	TOPO_DOM: Cytoplasmic => ECO:0000305\|PubMed:19383799

Chain	Residue	Details
G	MET1-GLU7
H	MET1-GLU7
I	MET1-GLU7
J	MET1-GLU7
K	MET1-GLU7
L	MET1-GLU7

site_id	SWS_FT_FI2
Number of Residues	120
Details	TRANSMEM: Helical; Signal-anchor for type II membrane protein => ECO:0000255

Chain	Residue	Details
G	ILE8-ALA28
H	ILE8-ALA28
I	ILE8-ALA28
J	ILE8-ALA28
K	ILE8-ALA28
L	ILE8-ALA28
D	MET89-ALA109
D	PHE148-TRP168
D	LEU199-PHE219
D	VAL239-GLY259

site_id	SWS_FT_FI3
Number of Residues	924
Details	TOPO_DOM: Periplasmic => ECO:0000305\|PubMed:19383799

Chain	Residue	Details
G	ALA29-LYS183
H	ALA29-LYS183
I	ALA29-LYS183
J	ALA29-LYS183
K	ALA29-LYS183
L	ALA29-LYS183

site_id	SWS_FT_FI4
Number of Residues	2
Details	TOPO_DOM: Periplasmic => ECO:0000269\|PubMed:15919996

Chain	Residue	Details
A	ASN260
D	ASN260

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)