7C4S
Sphingosine-1-phosphate receptor 3 with a natural ligand.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003376 | biological_process | sphingosine-1-phosphate receptor signaling pathway |
| A | 0004930 | molecular_function | G protein-coupled receptor activity |
| A | 0005178 | molecular_function | integrin binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006954 | biological_process | inflammatory response |
| A | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| A | 0007189 | biological_process | adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| A | 0007193 | biological_process | adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway |
| A | 0007204 | biological_process | positive regulation of cytosolic calcium ion concentration |
| A | 0007219 | biological_process | Notch signaling pathway |
| A | 0008284 | biological_process | positive regulation of cell population proliferation |
| A | 0008289 | molecular_function | lipid binding |
| A | 0009653 | biological_process | anatomical structure morphogenesis |
| A | 0016020 | cellular_component | membrane |
| A | 0019222 | biological_process | regulation of metabolic process |
| A | 0032651 | biological_process | regulation of interleukin-1 beta production |
| A | 0038036 | molecular_function | sphingosine-1-phosphate receptor activity |
| A | 1903141 | biological_process | negative regulation of establishment of endothelial barrier |
| B | 0003376 | biological_process | sphingosine-1-phosphate receptor signaling pathway |
| B | 0004930 | molecular_function | G protein-coupled receptor activity |
| B | 0005178 | molecular_function | integrin binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006954 | biological_process | inflammatory response |
| B | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| B | 0007189 | biological_process | adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| B | 0007193 | biological_process | adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway |
| B | 0007204 | biological_process | positive regulation of cytosolic calcium ion concentration |
| B | 0007219 | biological_process | Notch signaling pathway |
| B | 0008284 | biological_process | positive regulation of cell population proliferation |
| B | 0008289 | molecular_function | lipid binding |
| B | 0009653 | biological_process | anatomical structure morphogenesis |
| B | 0016020 | cellular_component | membrane |
| B | 0019222 | biological_process | regulation of metabolic process |
| B | 0032651 | biological_process | regulation of interleukin-1 beta production |
| B | 0038036 | molecular_function | sphingosine-1-phosphate receptor activity |
| B | 1903141 | biological_process | negative regulation of establishment of endothelial barrier |
Functional Information from PROSITE/UniProt
| site_id | PS00152 |
| Number of Residues | 10 |
| Details | ATPASE_ALPHA_BETA ATP synthase alpha and beta subunits signature. PALDPSRSKS |
| Chain | Residue | Details |
| A | PRO330-SER339 |
| site_id | PS00237 |
| Number of Residues | 17 |
| Details | G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASTcSLLAIAIERHLtM |
| Chain | Residue | Details |
| A | ALA124-MET140 |
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH |
| Chain | Residue | Details |
| L | TYR192-HIS198 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 164 |
| Details | TOPO_DOM: Extracellular => ECO:0000250 |
| Chain | Residue | Details |
| A | MET1-THR40 | |
| A | LYS102-GLU115 | |
| A | HIS180-LYS195 | |
| A | ASP266-GLN281 | |
| B | MET1-THR40 | |
| B | LYS102-GLU115 | |
| B | HIS180-LYS195 | |
| B | ASP266-GLN281 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 48 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000250 |
| Chain | Residue | Details |
| A | LEU41-TRP65 | |
| B | LEU41-TRP65 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 250 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000250 |
| Chain | Residue | Details |
| A | LYS66-ASN72 | |
| A | GLU135-ARG153 | |
| A | ARG217-ARG243 | |
| A | LYS303-ASN378 | |
| B | LYS66-ASN72 | |
| B | GLU135-ARG153 | |
| B | ARG217-ARG243 | |
| B | LYS303-ASN378 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 56 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000250 |
| Chain | Residue | Details |
| A | ARG73-LYS101 | |
| B | ARG73-LYS101 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 36 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000250 |
| Chain | Residue | Details |
| A | GLY116-ILE134 | |
| B | GLY116-ILE134 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 50 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000250 |
| Chain | Residue | Details |
| A | VAL154-LEU179 | |
| B | VAL154-LEU179 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000250 |
| Chain | Residue | Details |
| A | TYR196-ALA216 | |
| B | TYR196-ALA216 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 42 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000250 |
| Chain | Residue | Details |
| A | THR244-ILE265 | |
| B | THR244-ILE265 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000250 |
| Chain | Residue | Details |
| A | TRP282-SER302 | |
| B | TRP282-SER302 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| B | SER326 | |
| A | SER326 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| B | GLN15 | |
| A | GLN15 |
