7C11

Formate--tetrahydrofolate ligase from Methylobacterium extorquens CM4 strain

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004329	molecular_function	formate-tetrahydrofolate ligase activity
A	0005524	molecular_function	ATP binding
A	0006730	biological_process	one-carbon metabolic process
A	0016874	molecular_function	ligase activity
A	0035999	biological_process	tetrahydrofolate interconversion
B	0004329	molecular_function	formate-tetrahydrofolate ligase activity
B	0005524	molecular_function	ATP binding
B	0006730	biological_process	one-carbon metabolic process
B	0016874	molecular_function	ligase activity
B	0035999	biological_process	tetrahydrofolate interconversion
C	0004329	molecular_function	formate-tetrahydrofolate ligase activity
C	0005524	molecular_function	ATP binding
C	0006730	biological_process	one-carbon metabolic process
C	0016874	molecular_function	ligase activity
C	0035999	biological_process	tetrahydrofolate interconversion
D	0004329	molecular_function	formate-tetrahydrofolate ligase activity
D	0005524	molecular_function	ATP binding
D	0006730	biological_process	one-carbon metabolic process
D	0016874	molecular_function	ligase activity
D	0035999	biological_process	tetrahydrofolate interconversion
M	0004329	molecular_function	formate-tetrahydrofolate ligase activity
M	0005524	molecular_function	ATP binding
M	0006730	biological_process	one-carbon metabolic process
M	0016874	molecular_function	ligase activity
M	0035999	biological_process	tetrahydrofolate interconversion
N	0004329	molecular_function	formate-tetrahydrofolate ligase activity
N	0005524	molecular_function	ATP binding
N	0006730	biological_process	one-carbon metabolic process
N	0016874	molecular_function	ligase activity
N	0035999	biological_process	tetrahydrofolate interconversion
O	0004329	molecular_function	formate-tetrahydrofolate ligase activity
O	0005524	molecular_function	ATP binding
O	0006730	biological_process	one-carbon metabolic process
O	0016874	molecular_function	ligase activity
O	0035999	biological_process	tetrahydrofolate interconversion
P	0004329	molecular_function	formate-tetrahydrofolate ligase activity
P	0005524	molecular_function	ATP binding
P	0006730	biological_process	one-carbon metabolic process
P	0016874	molecular_function	ligase activity
P	0035999	biological_process	tetrahydrofolate interconversion

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue TLA D 601

Chain	Residue
B	ASN152
B	ILE156
B	ARG228
D	ASN152

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site_id	AC2
Number of Residues	3
Details	binding site for residue ACT D 602

Chain	Residue
D	THR72
D	ARG94
D	GLU298

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site_id	AC3
Number of Residues	10
Details	binding site for residue FLC N 601

Chain	Residue
N	PHE188
N	ARG228
P	ILE148
P	ASN152
P	ILE156
P	ASP157
P	VAL158
P	PHE188
N	ASN152
N	ILE156

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Functional Information from PROSITE/UniProt

site_id	PS00721
Number of Residues	11
Details	FTHFS_1 Formate--tetrahydrofolate ligase signature 1. GMKGGAAGGGK

Chain	Residue	Details
A	GLY103-LYS113

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site_id	PS00722
Number of Residues	12
Details	FTHFS_2 Formate--tetrahydrofolate ligase signature 2. VATIRALKmHGG

Chain	Residue	Details
A	VAL328-GLY339

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01543

Chain	Residue	Details
A	THR65
B	THR65
C	THR65
D	THR65
M	THR65
N	THR65
O	THR65
P	THR65

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