Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7AST

Apo Human RNA Polymerase III

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000428	cellular_component	DNA-directed RNA polymerase complex
A	0001056	molecular_function	RNA polymerase III activity
A	0003676	molecular_function	nucleic acid binding
A	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005666	cellular_component	RNA polymerase III complex
A	0005829	cellular_component	cytosol
A	0006351	biological_process	DNA-templated transcription
A	0006383	biological_process	transcription by RNA polymerase III
A	0006386	biological_process	termination of RNA polymerase III transcription
A	0008270	molecular_function	zinc ion binding
A	0045087	biological_process	innate immune response
A	0046872	molecular_function	metal ion binding
A	0051607	biological_process	defense response to virus
A	0055029	cellular_component	nuclear DNA-directed RNA polymerase complex
B	0000428	cellular_component	DNA-directed RNA polymerase complex
B	0001054	molecular_function	RNA polymerase I activity
B	0001055	molecular_function	RNA polymerase II activity
B	0001056	molecular_function	RNA polymerase III activity
B	0003677	molecular_function	DNA binding
B	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005665	cellular_component	RNA polymerase II, core complex
B	0005666	cellular_component	RNA polymerase III complex
B	0005730	cellular_component	nucleolus
B	0005736	cellular_component	RNA polymerase I complex
B	0005829	cellular_component	cytosol
B	0006351	biological_process	DNA-templated transcription
B	0006356	biological_process	regulation of transcription by RNA polymerase I
B	0006360	biological_process	transcription by RNA polymerase I
B	0006366	biological_process	transcription by RNA polymerase II
B	0008270	molecular_function	zinc ion binding
B	0042797	biological_process	tRNA transcription by RNA polymerase III
B	0046872	molecular_function	metal ion binding
C	0000428	cellular_component	DNA-directed RNA polymerase complex
C	0001054	molecular_function	RNA polymerase I activity
C	0001055	molecular_function	RNA polymerase II activity
C	0001056	molecular_function	RNA polymerase III activity
C	0003677	molecular_function	DNA binding
C	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005665	cellular_component	RNA polymerase II, core complex
C	0005666	cellular_component	RNA polymerase III complex
C	0005730	cellular_component	nucleolus
C	0005736	cellular_component	RNA polymerase I complex
C	0005829	cellular_component	cytosol
C	0006351	biological_process	DNA-templated transcription
C	0006356	biological_process	regulation of transcription by RNA polymerase I
C	0006360	biological_process	transcription by RNA polymerase I
C	0006366	biological_process	transcription by RNA polymerase II
C	0006383	biological_process	transcription by RNA polymerase III
C	0008270	molecular_function	zinc ion binding
C	0046872	molecular_function	metal ion binding
D	0000428	cellular_component	DNA-directed RNA polymerase complex
D	0001054	molecular_function	RNA polymerase I activity
D	0001055	molecular_function	RNA polymerase II activity
D	0001056	molecular_function	RNA polymerase III activity
D	0003677	molecular_function	DNA binding
D	0003697	molecular_function	single-stranded DNA binding
D	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005665	cellular_component	RNA polymerase II, core complex
D	0005666	cellular_component	RNA polymerase III complex
D	0005730	cellular_component	nucleolus
D	0005736	cellular_component	RNA polymerase I complex
D	0005829	cellular_component	cytosol
D	0006351	biological_process	DNA-templated transcription
D	0006360	biological_process	transcription by RNA polymerase I
D	0006366	biological_process	transcription by RNA polymerase II
D	0006383	biological_process	transcription by RNA polymerase III
D	0032993	cellular_component	protein-DNA complex
E	0000428	cellular_component	DNA-directed RNA polymerase complex
E	0001054	molecular_function	RNA polymerase I activity
E	0001055	molecular_function	RNA polymerase II activity
E	0001056	molecular_function	RNA polymerase III activity
E	0001650	cellular_component	fibrillar center
E	0003677	molecular_function	DNA binding
E	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005665	cellular_component	RNA polymerase II, core complex
E	0005666	cellular_component	RNA polymerase III complex
E	0005730	cellular_component	nucleolus
E	0005736	cellular_component	RNA polymerase I complex
E	0005829	cellular_component	cytosol
E	0006351	biological_process	DNA-templated transcription
E	0006360	biological_process	transcription by RNA polymerase I
E	0006366	biological_process	transcription by RNA polymerase II
E	0042797	biological_process	tRNA transcription by RNA polymerase III
F	0000428	cellular_component	DNA-directed RNA polymerase complex
F	0001054	molecular_function	RNA polymerase I activity
F	0001055	molecular_function	RNA polymerase II activity
F	0001056	molecular_function	RNA polymerase III activity
F	0003677	molecular_function	DNA binding
F	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005665	cellular_component	RNA polymerase II, core complex
F	0005666	cellular_component	RNA polymerase III complex
F	0005730	cellular_component	nucleolus
F	0005736	cellular_component	RNA polymerase I complex
F	0005829	cellular_component	cytosol
F	0006351	biological_process	DNA-templated transcription
F	0006362	biological_process	transcription elongation by RNA polymerase I
F	0006366	biological_process	transcription by RNA polymerase II
F	0016591	cellular_component	RNA polymerase II, holoenzyme
F	0042797	biological_process	tRNA transcription by RNA polymerase III
F	0050821	biological_process	protein stabilization
F	1990062	cellular_component	RPAP3/R2TP/prefoldin-like complex
G	0000428	cellular_component	DNA-directed RNA polymerase complex
G	0001054	molecular_function	RNA polymerase I activity
G	0001056	molecular_function	RNA polymerase III activity
G	0003677	molecular_function	DNA binding
G	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005666	cellular_component	RNA polymerase III complex
G	0005730	cellular_component	nucleolus
G	0005736	cellular_component	RNA polymerase I complex
G	0006351	biological_process	DNA-templated transcription
G	0006362	biological_process	transcription elongation by RNA polymerase I
G	0006383	biological_process	transcription by RNA polymerase III
G	0046983	molecular_function	protein dimerization activity
G	0055029	cellular_component	nuclear DNA-directed RNA polymerase complex
H	0000428	cellular_component	DNA-directed RNA polymerase complex
H	0001054	molecular_function	RNA polymerase I activity
H	0001056	molecular_function	RNA polymerase III activity
H	0001650	cellular_component	fibrillar center
H	0003677	molecular_function	DNA binding
H	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005666	cellular_component	RNA polymerase III complex
H	0005730	cellular_component	nucleolus
H	0005736	cellular_component	RNA polymerase I complex
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006351	biological_process	DNA-templated transcription
H	0006360	biological_process	transcription by RNA polymerase I
H	0006383	biological_process	transcription by RNA polymerase III
H	0046983	molecular_function	protein dimerization activity
I	0000166	molecular_function	nucleotide binding
I	0000428	cellular_component	DNA-directed RNA polymerase complex
I	0001635	molecular_function	calcitonin gene-related peptide receptor activity
I	0001669	cellular_component	acrosomal vesicle
I	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005666	cellular_component	RNA polymerase III complex
I	0005829	cellular_component	cytosol
I	0005886	cellular_component	plasma membrane
I	0006352	biological_process	DNA-templated transcription initiation
I	0006383	biological_process	transcription by RNA polymerase III
I	0006384	biological_process	transcription initiation at RNA polymerase III promoter
I	0007218	biological_process	neuropeptide signaling pathway
I	0009360	cellular_component	DNA polymerase III complex
I	0030880	cellular_component	RNA polymerase complex
I	0044237	biological_process	cellular metabolic process
I	0045087	biological_process	innate immune response
I	0051607	biological_process	defense response to virus
J	0000428	cellular_component	DNA-directed RNA polymerase complex
J	0003677	molecular_function	DNA binding
J	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005666	cellular_component	RNA polymerase III complex
J	0005813	cellular_component	centrosome
J	0005829	cellular_component	cytosol
J	0006139	biological_process	nucleobase-containing compound metabolic process
J	0006351	biological_process	DNA-templated transcription
J	0006352	biological_process	DNA-templated transcription initiation
J	0006383	biological_process	transcription by RNA polymerase III
J	0006384	biological_process	transcription initiation at RNA polymerase III promoter
J	0043231	cellular_component	intracellular membrane-bounded organelle
J	0045087	biological_process	innate immune response
J	0051607	biological_process	defense response to virus
K	0000428	cellular_component	DNA-directed RNA polymerase complex
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005666	cellular_component	RNA polymerase III complex
K	0005829	cellular_component	cytosol
K	0006351	biological_process	DNA-templated transcription
K	0042797	biological_process	tRNA transcription by RNA polymerase III
K	0045087	biological_process	innate immune response
K	0051607	biological_process	defense response to virus
L	0000428	cellular_component	DNA-directed RNA polymerase complex
L	0003677	molecular_function	DNA binding
L	0003682	molecular_function	chromatin binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005666	cellular_component	RNA polymerase III complex
L	0005829	cellular_component	cytosol
L	0006383	biological_process	transcription by RNA polymerase III
L	0032728	biological_process	positive regulation of interferon-beta production
L	0042797	biological_process	tRNA transcription by RNA polymerase III
L	0045087	biological_process	innate immune response
L	0045089	biological_process	positive regulation of innate immune response
L	0051607	biological_process	defense response to virus
M	0000428	cellular_component	DNA-directed RNA polymerase complex
M	0001056	molecular_function	RNA polymerase III activity
M	0003677	molecular_function	DNA binding
M	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0005666	cellular_component	RNA polymerase III complex
M	0005737	cellular_component	cytoplasm
M	0005829	cellular_component	cytosol
M	0006351	biological_process	DNA-templated transcription
M	0008270	molecular_function	zinc ion binding
M	0016779	molecular_function	nucleotidyltransferase activity
M	0032549	molecular_function	ribonucleoside binding
M	0032728	biological_process	positive regulation of interferon-beta production
M	0034062	molecular_function	5'-3' RNA polymerase activity
M	0042796	biological_process	snRNA transcription by RNA polymerase III
M	0045087	biological_process	innate immune response
M	0045089	biological_process	positive regulation of innate immune response
M	0046872	molecular_function	metal ion binding
M	0051607	biological_process	defense response to virus
M	0071667	molecular_function	DNA/RNA hybrid binding
N	0000287	molecular_function	magnesium ion binding
N	0000428	cellular_component	DNA-directed RNA polymerase complex
N	0001056	molecular_function	RNA polymerase III activity
N	0003677	molecular_function	DNA binding
N	0003682	molecular_function	chromatin binding
N	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0005666	cellular_component	RNA polymerase III complex
N	0005737	cellular_component	cytoplasm
N	0005829	cellular_component	cytosol
N	0006351	biological_process	DNA-templated transcription
N	0008270	molecular_function	zinc ion binding
N	0016020	cellular_component	membrane
N	0016779	molecular_function	nucleotidyltransferase activity
N	0031981	cellular_component	nuclear lumen
N	0032728	biological_process	positive regulation of interferon-beta production
N	0032991	cellular_component	protein-containing complex
N	0034062	molecular_function	5'-3' RNA polymerase activity
N	0042797	biological_process	tRNA transcription by RNA polymerase III
N	0045087	biological_process	innate immune response
N	0046872	molecular_function	metal ion binding
N	0051607	biological_process	defense response to virus
N	0071667	molecular_function	DNA/RNA hybrid binding
X	0000428	cellular_component	DNA-directed RNA polymerase complex
X	0003677	molecular_function	DNA binding
X	0003697	molecular_function	single-stranded DNA binding
X	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
X	0005515	molecular_function	protein binding
X	0005634	cellular_component	nucleus
X	0005654	cellular_component	nucleoplasm
X	0005666	cellular_component	RNA polymerase III complex
X	0005829	cellular_component	cytosol
X	0006351	biological_process	DNA-templated transcription
X	0006359	biological_process	regulation of transcription by RNA polymerase III
X	0032728	biological_process	positive regulation of interferon-beta production
X	0045087	biological_process	innate immune response
X	0045089	biological_process	positive regulation of innate immune response
X	0051607	biological_process	defense response to virus
Z	0000428	cellular_component	DNA-directed RNA polymerase complex
Z	0003677	molecular_function	DNA binding
Z	0003690	molecular_function	double-stranded DNA binding
Z	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
Z	0005515	molecular_function	protein binding
Z	0005634	cellular_component	nucleus
Z	0005654	cellular_component	nucleoplasm
Z	0005666	cellular_component	RNA polymerase III complex
Z	0005829	cellular_component	cytosol
Z	0006359	biological_process	regulation of transcription by RNA polymerase III
Z	0006383	biological_process	transcription by RNA polymerase III
Z	0032728	biological_process	positive regulation of interferon-beta production
Z	0045087	biological_process	innate immune response
Z	0045089	biological_process	positive regulation of innate immune response
Z	0051539	molecular_function	4 iron, 4 sulfur cluster binding
Z	0051607	biological_process	defense response to virus

Functional Information from PROSITE/UniProt

site_id	PS01166
Number of Residues	13
Details	RNA_POL_BETA RNA polymerases beta chain signature. GdKFSSrHGQKGV

Chain	Residue	Details
M	GLY894-VAL906

site_id	PS01110
Number of Residues	14
Details	RNA_POL_H_23KD RNA polymerases H / 23 Kd subunits signature. HELVPEHvvMtkEE

Chain	Residue	Details
F	HIS142-GLU155

site_id	PS00446
Number of Residues	41
Details	RNA_POL_D_30KD RNA polymerases D / 30 to 40 Kd subunits signature. NAFRRillaevptmAvekVlvynNtSivqDEiLAhRLGLIP

Chain	Residue	Details
H	ASN74-PRO114

site_id	PS01154
Number of Residues	32
Details	RNA_POL_L_13KD RNA polymerases L / 13 to 16 Kd subunits signature. LheEdHTLgNsLrymImknpeVefcgYtttHP

Chain	Residue	Details
G	LEU44-PRO75

site_id	PS01111
Number of Residues	15
Details	RNA_POL_K_14KD RNA polymerases K / 14 to 18 Kd subunits signature. TkYErARvLGtRAlQ

Chain	Residue	Details
E	THR58-GLN72

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. FRCVVFH

Chain	Residue	Details
J	PHE72-HIS78

site_id	PS01112
Number of Residues	10
Details	RNA_POL_N_8KD RNA polymerases N / 8 Kd subunits signature. IIPVrCFTCG

Chain	Residue	Details
B	ILE2-GLY11

site_id	PS00466
Number of Residues	38
Details	ZF_TFIIS_1 Zinc finger TFIIS-type signature. CpkCehprayfmqLQTRSaDEPmttfykCcnaq.CghrW

Chain	Residue	Details
A	CYS69-TRP106

site_id	PS01030
Number of Residues	25
Details	RNA_POL_M_15KD RNA polymerases M / 15 Kd subunits signature. FCpGCGNGLiveegqrchrfs..CntC

Chain	Residue	Details
A	PHE4-CYS28

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:18669648

Chain	Residue	Details
X	SER194
B	CYS10
B	CYS44

site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269\|PubMed:33558764, ECO:0000269\|PubMed:33558766, ECO:0000269\|PubMed:33674783, ECO:0007744\|PDB:7D58, ECO:0007744\|PDB:7DN3

Chain	Residue	Details
M	ARG1046
M	ASP432
Z	CYS290
M	ARG213
M	LYS1019

site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269\|PubMed:33558764, ECO:0000269\|PubMed:33558766, ECO:0007744\|PDB:7D58

Chain	Residue	Details
Z	CYS307
Z	CYS296
L	ARG99

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: N-acetylalanine => ECO:0007744\|PubMed:22814378

Chain	Residue	Details
L	LYS152
Z	ALA2
L	LYS160
L	LYS190
L	LYS199
L	LYS310

site_id	SWS_FT_FI5
Number of Residues	1
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744\|PubMed:28112733

Chain	Residue	Details
Z	LYS5
L	LYS396
N	LYS1323

site_id	SWS_FT_FI6
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744\|PubMed:25218447, ECO:0007744\|PubMed:25772364, ECO:0007744\|PubMed:28112733

Chain	Residue	Details
Z	LYS7
M	ASP753

site_id	SWS_FT_FI7
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269\|PubMed:33674783, ECO:0000269\|PubMed:34675218, ECO:0007744\|PDB:7DN3, ECO:0007744\|PDB:7FJJ

Chain	Residue	Details
K	LYS432
M	LYS896

site_id	SWS_FT_FI8
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269\|PubMed:33558764, ECO:0000269\|PubMed:33558766, ECO:0007744\|PDB:7AE1, ECO:0007744\|PDB:7D58

Chain	Residue	Details
K	LYS659
N	ARG1305
M	LYS904

site_id	SWS_FT_FI9
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269\|PubMed:33558766, ECO:0000269\|PubMed:33674783, ECO:0007744\|PDB:7D58, ECO:0007744\|PDB:7DN3

Chain	Residue	Details
L	LYS302
M	ARG1039

site_id	SWS_FT_FI10
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269\|PubMed:33558764, ECO:0000269\|PubMed:33558766, ECO:0000269\|PubMed:33674783, ECO:0007744\|PDB:7AE1, ECO:0007744\|PDB:7D58, ECO:0007744\|PDB:7DN3

Chain	Residue	Details
N	ASP503
M	CYS1080

site_id	SWS_FT_FI11
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269\|PubMed:33558764, ECO:0000269\|PubMed:33674783, ECO:0000269\|PubMed:34675218, ECO:0007744\|PDB:7AE1, ECO:0007744\|PDB:7DN3, ECO:0007744\|PDB:7FJJ

Chain	Residue	Details
M	CYS1083

site_id	SWS_FT_FI12
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269\|PubMed:33558764, ECO:0000269\|PubMed:33558766, ECO:0000269\|PubMed:33674783, ECO:0000269\|PubMed:34675218, ECO:0007744\|PDB:7AE1, ECO:0007744\|PDB:7D58, ECO:0007744\|PDB:7DN3, ECO:0007744\|PDB:7FJJ

Chain	Residue	Details
M	CYS1095
M	CYS1092

site_id	SWS_FT_FI13
Number of Residues	1
Details	SITE: Critical in trapping poly(dT) in Pol III-mediated transcription termination => ECO:0000305\|PubMed:34675218

Chain	Residue	Details
M	PHE429

site_id	SWS_FT_FI14
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0007744\|PubMed:19608861

Chain	Residue	Details
N	LYS445

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)