7AKK

Structure of a complement factor-receptor complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004866	molecular_function	endopeptidase inhibitor activity
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
B	0004866	molecular_function	endopeptidase inhibitor activity
C	0004866	molecular_function	endopeptidase inhibitor activity
E	0004866	molecular_function	endopeptidase inhibitor activity
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space

Functional Information from PROSITE/UniProt

site_id	PS00477
Number of Residues	9
Details	ALPHA_2_MACROGLOBULIN Alpha-2-macroglobulin family thiolester region signature. PsGCGEQnM

Chain	Residue	Details
A	PRO904-MET912

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
D	ASN224
H	ASN224

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site_id	SWS_FT_FI2
Number of Residues	4
Details	SITE: Cleavage; by factor I

Chain	Residue	Details
C	SER16
C	SER48
C	SER275
C	SER281
A	ARG1200
A	LYS1217
E	ARG1200
E	LYS1217

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site_id	SWS_FT_FI3
Number of Residues	2
Details	SITE: Coordinates Mg2+ for interaction with Complement factor B Bb fragment => ECO:0000269|PubMed:28264884, ECO:0000269|PubMed:31507604

Chain	Residue	Details
B	ASN63
C	ASN63

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site_id	SWS_FT_FI4
Number of Residues	6
Details	MOD_RES: Phosphoserine; by FAM20C => ECO:0000269|PubMed:26091039

Chain	Residue	Details
A	SER865
A	GLY1218
A	CYS1470
E	SER865
E	GLY1218
E	CYS1470

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site_id	SWS_FT_FI5
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:14760718, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:17051150

Chain	Residue	Details
A	ASN836
E	ASN836

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site_id	SWS_FT_FI6
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952

Chain	Residue	Details
A	GLU1514
E	GLU1514

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site_id	SWS_FT_FI7
Number of Residues	4
Details	CROSSLNK: Isoglutamyl cysteine thioester (Cys-Gln)

Chain	Residue	Details
A	CYS907
A	GLN910
E	CYS907
E	GLN910

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