6YIH
Structure of Chromosomal Passenger Complex (CPC) bound to phosphorylated Histone 3 peptide at 2.6 A.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000228 | cellular_component | nuclear chromosome |
| A | 0000278 | biological_process | mitotic cell cycle |
| A | 0000281 | biological_process | mitotic cytokinesis |
| A | 0000775 | cellular_component | chromosome, centromeric region |
| A | 0000776 | cellular_component | kinetochore |
| A | 0004869 | molecular_function | cysteine-type endopeptidase inhibitor activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005694 | cellular_component | chromosome |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005819 | cellular_component | spindle |
| A | 0005829 | cellular_component | cytosol |
| A | 0005856 | cellular_component | cytoskeleton |
| A | 0005874 | cellular_component | microtubule |
| A | 0006468 | biological_process | protein phosphorylation |
| A | 0006915 | biological_process | apoptotic process |
| A | 0007059 | biological_process | chromosome segregation |
| A | 0007605 | biological_process | sensory perception of sound |
| A | 0008017 | molecular_function | microtubule binding |
| A | 0008284 | biological_process | positive regulation of cell population proliferation |
| A | 0015630 | cellular_component | microtubule cytoskeleton |
| A | 0019899 | molecular_function | enzyme binding |
| A | 0030496 | cellular_component | midbody |
| A | 0031267 | molecular_function | small GTPase binding |
| A | 0031503 | biological_process | protein-containing complex localization |
| A | 0032133 | cellular_component | chromosome passenger complex |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0042981 | biological_process | regulation of apoptotic process |
| A | 0043066 | biological_process | negative regulation of apoptotic process |
| A | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051087 | molecular_function | protein-folding chaperone binding |
| A | 0051256 | biological_process | mitotic spindle midzone assembly |
| A | 0051301 | biological_process | cell division |
| A | 0090267 | biological_process | positive regulation of mitotic cell cycle spindle assembly checkpoint |
| A | 0090307 | biological_process | mitotic spindle assembly |
| A | 1901970 | biological_process | positive regulation of mitotic sister chromatid separation |
| A | 1902425 | biological_process | positive regulation of attachment of mitotic spindle microtubules to kinetochore |
| A | 1903490 | biological_process | positive regulation of mitotic cytokinesis |
| A | 1990713 | cellular_component | survivin complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 201 |
| Chain | Residue |
| A | CYS57 |
| A | CYS60 |
| A | HIS77 |
| A | CYS84 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 202 |
| Chain | Residue |
| A | PHE27 |
| A | LEU28 |
| A | GLU29 |
| A | HOH304 |
| C | HIS10 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | MOD_RES: Citrulline; alternate => ECO:0000269|PubMed:16567635 |
| Chain | Residue | Details |
| D | ARG2 | |
| A | CYS60 | |
| A | HIS77 | |
| A | CYS84 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine; by HASPIN => ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088 |
| Chain | Residue | Details |
| D | TPO3 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708 |
| Chain | Residue | Details |
| D | LYS4 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: 5-glutamyl serotonin; alternate => ECO:0000269|PubMed:30867594 |
| Chain | Residue | Details |
| D | GLN5 | |
| A | LYS90 | |
| A | LYS110 | |
| A | LYS112 | |
| A | LYS115 | |
| A | LYS121 | |
| A | LYS129 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine; by PKC => ECO:0000269|PubMed:20228790 |
| Chain | Residue | Details |
| D | THR6 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Symmetric dimethylarginine; by PRMT5; alternate => ECO:0000250|UniProtKB:P68433 |
| Chain | Residue | Details |
| D | ARG8 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:11242053, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708 |
| Chain | Residue | Details |
| D | LYS9 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; alternate; by AURKB, AURKC, RPS6KA3, RPS6KA4 and RPS6KA5 => ECO:0000269|PubMed:10464286, ECO:0000269|PubMed:11856369, ECO:0000269|PubMed:12560483, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16457588 |
| Chain | Residue | Details |
| D | SER10 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine; by PKC and CHEK1 => ECO:0000269|PubMed:12560483, ECO:0000269|PubMed:18066052, ECO:0000269|PubMed:18243098, ECO:0000269|PubMed:22901803 |
| Chain | Residue | Details |
| D | THR11 |
