6Y5V
Structure of Human Potassium Chloride Transporter KCC3b (S45D/T940D/T997D) in KCl
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001525 | biological_process | angiogenesis |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006813 | biological_process | potassium ion transport |
| A | 0006884 | biological_process | cell volume homeostasis |
| A | 0007268 | biological_process | chemical synaptic transmission |
| A | 0008519 | molecular_function | ammonium transmembrane transporter activity |
| A | 0015293 | molecular_function | symporter activity |
| A | 0015377 | molecular_function | chloride:monoatomic cation symporter activity |
| A | 0015379 | molecular_function | potassium:chloride symporter activity |
| A | 0016020 | cellular_component | membrane |
| A | 0016323 | cellular_component | basolateral plasma membrane |
| A | 0019901 | molecular_function | protein kinase binding |
| A | 0022857 | molecular_function | transmembrane transporter activity |
| A | 0030424 | cellular_component | axon |
| A | 0045202 | cellular_component | synapse |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0055064 | biological_process | chloride ion homeostasis |
| A | 0055075 | biological_process | potassium ion homeostasis |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0071333 | biological_process | cellular response to glucose stimulus |
| A | 0071477 | biological_process | cellular hypotonic salinity response |
| A | 0071805 | biological_process | potassium ion transmembrane transport |
| A | 0140157 | biological_process | ammonium import across plasma membrane |
| A | 1902476 | biological_process | chloride transmembrane transport |
| A | 1990573 | biological_process | potassium ion import across plasma membrane |
| B | 0001525 | biological_process | angiogenesis |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0006813 | biological_process | potassium ion transport |
| B | 0006884 | biological_process | cell volume homeostasis |
| B | 0007268 | biological_process | chemical synaptic transmission |
| B | 0008519 | molecular_function | ammonium transmembrane transporter activity |
| B | 0015293 | molecular_function | symporter activity |
| B | 0015377 | molecular_function | chloride:monoatomic cation symporter activity |
| B | 0015379 | molecular_function | potassium:chloride symporter activity |
| B | 0016020 | cellular_component | membrane |
| B | 0016323 | cellular_component | basolateral plasma membrane |
| B | 0019901 | molecular_function | protein kinase binding |
| B | 0022857 | molecular_function | transmembrane transporter activity |
| B | 0030424 | cellular_component | axon |
| B | 0045202 | cellular_component | synapse |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0055064 | biological_process | chloride ion homeostasis |
| B | 0055075 | biological_process | potassium ion homeostasis |
| B | 0055085 | biological_process | transmembrane transport |
| B | 0071333 | biological_process | cellular response to glucose stimulus |
| B | 0071477 | biological_process | cellular hypotonic salinity response |
| B | 0071805 | biological_process | potassium ion transmembrane transport |
| B | 0140157 | biological_process | ammonium import across plasma membrane |
| B | 1902476 | biological_process | chloride transmembrane transport |
| B | 1990573 | biological_process | potassium ion import across plasma membrane |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1370 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000250|UniProtKB:Q9UP95 |
| Chain | Residue | Details |
| A | MET1-SER186 | |
| A | ALA189-GLU212 | |
| A | SER455-SER464 | |
| A | ALA546-PRO568 | |
| A | GLN613-ARG626 | |
| A | ILE666-SER1099 | |
| B | MET1-SER186 | |
| B | ALA189-GLU212 | |
| B | SER455-SER464 | |
| B | ALA546-PRO568 | |
| B | GLN613-ARG626 | |
| B | ILE666-SER1099 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 42 |
| Details | TRANSMEM: Discontinuously helical => ECO:0000250|UniProtKB:Q9UP95 |
| Chain | Residue | Details |
| A | THR136-LEU157 | |
| B | THR136-LEU157 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 356 |
| Details | TOPO_DOM: Extracellular => ECO:0000250|UniProtKB:Q9UP95 |
| Chain | Residue | Details |
| A | THR158-GLY165 | |
| A | VAL242-LEU264 | |
| A | SER314-SER433 | |
| A | GLY488-PRO518 | |
| B | THR158-GLY165 | |
| B | SER314-SER433 | |
| B | GLY488-PRO518 | |
| B | VAL242-LEU264 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 488 |
| Details | TRANSMEM: Helical => ECO:0000250|UniProtKB:Q9UP95 |
| Chain | Residue | Details |
| A | ASN265-ARG287 | |
| A | TYR288-LYS313 | |
| A | PHE434-ARG454 | |
| A | ILE465-PHE487 | |
| A | TRP519-GLN545 | |
| A | THR569-ASP589 | |
| A | LEU590-LEU612 | |
| A | TYR627-TRP649 | |
| A | TYR650-TYR665 | |
| B | VAL166-SER188 | |
| B | PHE213-LEU241 | |
| B | ASN265-ARG287 | |
| B | TYR288-LYS313 | |
| B | PHE434-ARG454 | |
| B | ILE465-PHE487 | |
| B | TRP519-GLN545 | |
| B | THR569-ASP589 | |
| B | LEU590-LEU612 | |
| B | TYR627-TRP649 | |
| B | TYR650-TYR665 | |
| A | VAL166-SER188 | |
| A | PHE213-LEU241 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 18 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q9UP95 |
| Chain | Residue | Details |
| A | THR446 | |
| A | GLY447 | |
| A | ILE448 | |
| A | MET449 | |
| A | TYR603 | |
| B | ASN147 | |
| B | ILE148 | |
| B | TYR232 | |
| B | PRO443 | |
| B | THR446 | |
| B | GLY447 | |
| B | ILE448 | |
| B | MET449 | |
| B | TYR603 | |
| A | ASN147 | |
| A | ILE148 | |
| A | TYR232 | |
| A | PRO443 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:19665974, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | ARG32 | |
| B | ARG32 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| B | SER69 | |
| B | SER97 | |
| A | SER69 | |
| A | SER97 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:34031912 |
| Chain | Residue | Details |
| B | SER685 | |
| B | SER930 | |
| A | SER685 | |
| A | SER930 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0000269|PubMed:34031912 |
| Chain | Residue | Details |
| A | THR727 | |
| B | THR727 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine; by OXSR1 and STK39 => ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:27485015, ECO:0000269|PubMed:34031912 |
| Chain | Residue | Details |
| A | ASP940 | |
| B | ASP940 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:19665974 |
| Chain | Residue | Details |
| A | SER972 | |
| A | SER978 | |
| B | SER972 | |
| B | SER978 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER981 | |
| B | SER981 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine; by OXSR1 and STK39 => ECO:0000269|PubMed:19665974 |
| Chain | Residue | Details |
| A | ASP997 | |
| B | ASP997 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:34031912 |
| Chain | Residue | Details |
| A | TYR1070 | |
| B | TYR1070 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 8 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN328 | |
| A | ASN347 | |
| A | ASN360 | |
| A | ASN377 | |
| B | ASN328 | |
| B | ASN347 | |
| B | ASN360 | |
| B | ASN377 |
