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6XUI

Crystal structure of human phosphoglucose isomerase in complex with inhibitor

Functional Information from GO Data
ChainGOidnamespacecontents
A0001701biological_processin utero embryonic development
A0001707biological_processmesoderm formation
A0002639biological_processpositive regulation of immunoglobulin production
A0004347molecular_functionglucose-6-phosphate isomerase activity
A0005125molecular_functioncytokine activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005975biological_processcarbohydrate metabolic process
A0006094biological_processgluconeogenesis
A0006096biological_processglycolytic process
A0006959biological_processhumoral immune response
A0007165biological_processsignal transduction
A0007599biological_processhemostasis
A0007611biological_processlearning or memory
A0008083molecular_functiongrowth factor activity
A0010595biological_processpositive regulation of endothelial cell migration
A0016020cellular_componentmembrane
A0016853molecular_functionisomerase activity
A0031625molecular_functionubiquitin protein ligase binding
A0032355biological_processresponse to estradiol
A0032570biological_processresponse to progesterone
A0033574biological_processresponse to testosterone
A0034101biological_processerythrocyte homeostasis
A0034774cellular_componentsecretory granule lumen
A0035902biological_processresponse to immobilization stress
A0035994biological_processresponse to muscle stretch
A0042593biological_processglucose homeostasis
A0043524biological_processnegative regulation of neuron apoptotic process
A0046686biological_processresponse to cadmium ion
A0048029molecular_functionmonosaccharide binding
A0051156biological_processglucose 6-phosphate metabolic process
A0060170cellular_componentciliary membrane
A0070062cellular_componentextracellular exosome
A0097367molecular_functioncarbohydrate derivative binding
A1901135biological_processcarbohydrate derivative metabolic process
A1904813cellular_componentficolin-1-rich granule lumen
B0001701biological_processin utero embryonic development
B0001707biological_processmesoderm formation
B0002639biological_processpositive regulation of immunoglobulin production
B0004347molecular_functionglucose-6-phosphate isomerase activity
B0005125molecular_functioncytokine activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0005975biological_processcarbohydrate metabolic process
B0006094biological_processgluconeogenesis
B0006096biological_processglycolytic process
B0006959biological_processhumoral immune response
B0007165biological_processsignal transduction
B0007599biological_processhemostasis
B0007611biological_processlearning or memory
B0008083molecular_functiongrowth factor activity
B0010595biological_processpositive regulation of endothelial cell migration
B0016020cellular_componentmembrane
B0016853molecular_functionisomerase activity
B0031625molecular_functionubiquitin protein ligase binding
B0032355biological_processresponse to estradiol
B0032570biological_processresponse to progesterone
B0033574biological_processresponse to testosterone
B0034101biological_processerythrocyte homeostasis
B0034774cellular_componentsecretory granule lumen
B0035902biological_processresponse to immobilization stress
B0035994biological_processresponse to muscle stretch
B0042593biological_processglucose homeostasis
B0043524biological_processnegative regulation of neuron apoptotic process
B0046686biological_processresponse to cadmium ion
B0048029molecular_functionmonosaccharide binding
B0051156biological_processglucose 6-phosphate metabolic process
B0060170cellular_componentciliary membrane
B0070062cellular_componentextracellular exosome
B0097367molecular_functioncarbohydrate derivative binding
B1901135biological_processcarbohydrate derivative metabolic process
B1904813cellular_componentficolin-1-rich granule lumen
C0001701biological_processin utero embryonic development
C0001707biological_processmesoderm formation
C0002639biological_processpositive regulation of immunoglobulin production
C0004347molecular_functionglucose-6-phosphate isomerase activity
C0005125molecular_functioncytokine activity
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0005975biological_processcarbohydrate metabolic process
C0006094biological_processgluconeogenesis
C0006096biological_processglycolytic process
C0006959biological_processhumoral immune response
C0007165biological_processsignal transduction
C0007599biological_processhemostasis
C0007611biological_processlearning or memory
C0008083molecular_functiongrowth factor activity
C0010595biological_processpositive regulation of endothelial cell migration
C0016020cellular_componentmembrane
C0016853molecular_functionisomerase activity
C0031625molecular_functionubiquitin protein ligase binding
C0032355biological_processresponse to estradiol
C0032570biological_processresponse to progesterone
C0033574biological_processresponse to testosterone
C0034101biological_processerythrocyte homeostasis
C0034774cellular_componentsecretory granule lumen
C0035902biological_processresponse to immobilization stress
C0035994biological_processresponse to muscle stretch
C0042593biological_processglucose homeostasis
C0043524biological_processnegative regulation of neuron apoptotic process
C0046686biological_processresponse to cadmium ion
C0048029molecular_functionmonosaccharide binding
C0051156biological_processglucose 6-phosphate metabolic process
C0060170cellular_componentciliary membrane
C0070062cellular_componentextracellular exosome
C0097367molecular_functioncarbohydrate derivative binding
C1901135biological_processcarbohydrate derivative metabolic process
C1904813cellular_componentficolin-1-rich granule lumen
D0001701biological_processin utero embryonic development
D0001707biological_processmesoderm formation
D0002639biological_processpositive regulation of immunoglobulin production
D0004347molecular_functionglucose-6-phosphate isomerase activity
D0005125molecular_functioncytokine activity
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0005975biological_processcarbohydrate metabolic process
D0006094biological_processgluconeogenesis
D0006096biological_processglycolytic process
D0006959biological_processhumoral immune response
D0007165biological_processsignal transduction
D0007599biological_processhemostasis
D0007611biological_processlearning or memory
D0008083molecular_functiongrowth factor activity
D0010595biological_processpositive regulation of endothelial cell migration
D0016020cellular_componentmembrane
D0016853molecular_functionisomerase activity
D0031625molecular_functionubiquitin protein ligase binding
D0032355biological_processresponse to estradiol
D0032570biological_processresponse to progesterone
D0033574biological_processresponse to testosterone
D0034101biological_processerythrocyte homeostasis
D0034774cellular_componentsecretory granule lumen
D0035902biological_processresponse to immobilization stress
D0035994biological_processresponse to muscle stretch
D0042593biological_processglucose homeostasis
D0043524biological_processnegative regulation of neuron apoptotic process
D0046686biological_processresponse to cadmium ion
D0048029molecular_functionmonosaccharide binding
D0051156biological_processglucose 6-phosphate metabolic process
D0060170cellular_componentciliary membrane
D0070062cellular_componentextracellular exosome
D0097367molecular_functioncarbohydrate derivative binding
D1901135biological_processcarbohydrate derivative metabolic process
D1904813cellular_componentficolin-1-rich granule lumen
Functional Information from PDB Data
site_idAC1
Number of Residues18
Detailsbinding site for residue PA5 A 601
ChainResidue
AILE156
AGLU357
ALYS518
AHOH704
AHOH750
AHOH765
AHOH783
AHOH784
AHOH918
DHIS388
AGLY157
AGLY158
ASER159
ASER209
ALYS210
ATHR211
ATHR214
AGLN353

site_idAC2
Number of Residues7
Detailsbinding site for residue PG6 A 602
ChainResidue
AARG20
ALEU23
ATHR398
AASN470
AARG471
AHOH865
DARG369

site_idAC3
Number of Residues18
Detailsbinding site for residue PA5 B 601
ChainResidue
BILE156
BGLY157
BGLY158
BSER159
BSER209
BLYS210
BTHR211
BTHR214
BGLN353
BGLU357
BLYS518
BHOH705
BHOH760
BHOH761
BHOH772
BHOH790
BHOH911
CHIS388

site_idAC4
Number of Residues7
Detailsbinding site for residue PG6 B 602
ChainResidue
BARG20
BLEU23
BMET400
BASN470
BARG471
BHOH987
CVAL370

site_idAC5
Number of Residues18
Detailsbinding site for residue PA5 C 601
ChainResidue
BHIS388
CILE156
CGLY157
CGLY158
CSER159
CSER209
CLYS210
CTHR211
CTHR214
CGLN353
CGLU357
CLYS518
CHOH717
CHOH750
CHOH765
CHOH796
CHOH855
CHOH860

site_idAC6
Number of Residues8
Detailsbinding site for residue PG6 C 602
ChainResidue
BARG369
CARG20
CLEU23
CGLY397
CTHR398
CMET400
CASN470
CARG471

site_idAC7
Number of Residues4
Detailsbinding site for residue GOL C 603
ChainResidue
BLEU516
CALA434
CGLY438
CHOH922

site_idAC8
Number of Residues6
Detailsbinding site for residue GOL C 604
ChainResidue
CLYS127
CSER130
CARG134
CGLN260
CASN261
CPHE263

site_idAC9
Number of Residues4
Detailsbinding site for residue PG6 D 601
ChainResidue
DARG20
DLEU23
DASN470
DARG471

site_idAD1
Number of Residues18
Detailsbinding site for residue PA5 D 602
ChainResidue
DGLN353
DGLU357
DLYS518
DHOH705
DHOH711
DHOH721
DHOH742
DHOH781
DHOH790
AHIS388
DILE156
DGLY157
DGLY158
DSER159
DSER209
DLYS210
DTHR211
DTHR214

Functional Information from PROSITE/UniProt
site_idPS00174
Number of Residues18
DetailsP_GLUCOSE_ISOMERASE_2 Phosphoglucose isomerase signature 2. GiIWdinsFDQwGVElgK
ChainResidueDetails
AGLY501-LYS518

site_idPS00765
Number of Residues14
DetailsP_GLUCOSE_ISOMERASE_1 Phosphoglucose isomerase signature 1. DwVGGRYSLwSAIG
ChainResidueDetails
AASP267-GLY280

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsACT_SITE: Proton donor => ECO:0000269|PubMed:11371164, ECO:0000269|PubMed:12573240, ECO:0000269|PubMed:12777791
ChainResidueDetails
BGLU357
CGLU357
DGLU357
AGLU357

site_idSWS_FT_FI2
Number of Residues8
DetailsACT_SITE: ACT_SITE => ECO:0000269|PubMed:11371164, ECO:0000269|PubMed:12573240, ECO:0000269|PubMed:12777791
ChainResidueDetails
BHIS388
BLYS518
CHIS388
CLYS518
DHIS388
DLYS518
AHIS388
ALYS518

site_idSWS_FT_FI3
Number of Residues24
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P06745
ChainResidueDetails
CHIS388
CLYS518
DGLY158
DSER209
DGLN353
DGLU357
DHIS388
DLYS518
AHIS388
ALYS518
BGLY158
BSER209
BGLN353
BGLU357
BHIS388
BLYS518
CGLY158
CSER209
CGLN353
CGLU357
AGLY158
ASER209
AGLN353
AGLU357

site_idSWS_FT_FI4
Number of Residues4
DetailsMOD_RES: N-acetylalanine => ECO:0000269|Ref.8, ECO:0007744|PubMed:19413330
ChainResidueDetails
BALA1
CALA1
DALA1
AALA1

site_idSWS_FT_FI5
Number of Residues8
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
BLYS11
BLYS141
CLYS11
CLYS141
DLYS11
DLYS141
ALYS11
ALYS141

site_idSWS_FT_FI6
Number of Residues4
DetailsMOD_RES: N6-(2-hydroxyisobutyryl)lysine => ECO:0000269|PubMed:29775581
ChainResidueDetails
BLYS33
CLYS33
DLYS33
ALYS33

site_idSWS_FT_FI7
Number of Residues8
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
BSER106
BSER454
CSER106
CSER454
DSER106
DSER454
ASER106
ASER454

site_idSWS_FT_FI8
Number of Residues4
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
CTHR108
DTHR108
ATHR108
BTHR108

site_idSWS_FT_FI9
Number of Residues4
DetailsMOD_RES: Phosphoserine; by CK2 => ECO:0000269|PubMed:11004567, ECO:0000269|PubMed:15637053
ChainResidueDetails
BSER184
CSER184
DSER184
ASER184

site_idSWS_FT_FI10
Number of Residues4
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q6P6V0
ChainResidueDetails
BTHR249
CTHR249
DTHR249
ATHR249

site_idSWS_FT_FI11
Number of Residues4
DetailsMOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P06745
ChainResidueDetails
ALYS453
BLYS453
CLYS453
DLYS453

219869

PDB entries from 2024-05-15

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