6XIW
Cryo-EM structure of the sodium leak channel NALCN-FAM155A complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005248 | molecular_function | voltage-gated sodium channel activity |
| A | 0005261 | molecular_function | monoatomic cation channel activity |
| A | 0005272 | molecular_function | sodium channel activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006814 | biological_process | sodium ion transport |
| A | 0016020 | cellular_component | membrane |
| A | 0022840 | molecular_function | leak channel activity |
| A | 0032224 | biological_process | positive regulation of synaptic transmission, cholinergic |
| A | 0032230 | biological_process | positive regulation of synaptic transmission, GABAergic |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| A | 0034702 | cellular_component | monoatomic ion channel complex |
| A | 0035725 | biological_process | sodium ion transmembrane transport |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0060075 | biological_process | regulation of resting membrane potential |
| A | 0070588 | biological_process | calcium ion transmembrane transport |
| A | 0071805 | biological_process | potassium ion transmembrane transport |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0015275 | molecular_function | stretch-activated, monoatomic cation-selective, calcium channel activity |
| B | 0098703 | biological_process | calcium ion import across plasma membrane |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| B | LEU40-ALA60 | |
| A | ASN1160-PRO1210 | |
| A | ILE1261-SER1271 | |
| A | VAL1319-SER1331 | |
| A | GLU1448-ILE1738 | |
| B | LEU417-GLN437 | |
| A | ARG159-ARG173 | |
| A | GLU323-ARG382 | |
| A | LEU440-SER447 | |
| A | GLU493-PRO502 | |
| A | ASP600-THR886 | |
| A | ASP940-THR947 | |
| A | ARG1004-LYS1015 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:33203861, ECO:0007744|PDB:7CM3 |
| Chain | Residue | Details |
| B | ASN217 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 253 |
| Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:32698188, ECO:0007744|PDB:6XIW |
| Chain | Residue | Details |
| A | PRO58-PRO65 | |
| A | PRO973-SER980 | |
| A | ALA1040-ALA1104 | |
| A | ILE1125-GLY1129 | |
| A | SER1228-PRO1236 | |
| A | LEU1294-ASN1296 | |
| A | GLY1358-ALA1378 | |
| A | MET1399-TYR1420 | |
| A | ALA130-SER137 | |
| A | PHE200-SER269 | |
| A | ILE290-PRO294 | |
| A | ASN404-ASP416 | |
| A | LEU469-SER472 | |
| A | VAL531-ALA543 | |
| A | LEU564-HIS569 | |
| A | SER907-ALA915 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=S2 of repeat I => ECO:0000269|PubMed:32698188, ECO:0007744|PDB:6XIW |
| Chain | Residue | Details |
| A | PRO66-MET90 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=S3 of repeat I => ECO:0000269|PubMed:32698188, ECO:0007744|PDB:6XIW |
| Chain | Residue | Details |
| A | TRP107-ILE129 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Voltage-sensor; Name=S4 of repeat I => ECO:0000269|PubMed:32698188, ECO:0007744|PDB:6XIW |
| Chain | Residue | Details |
| A | PRO138-PHE158 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 25 |
| Details | TRANSMEM: Helical; Name=S5 of repeat I => ECO:0000269|PubMed:32698188, ECO:0007744|PDB:6XIW |
| Chain | Residue | Details |
| A | SER174-MET199 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 76 |
| Details | INTRAMEM: Pore-forming => ECO:0000269|PubMed:32698188, ECO:0007744|PDB:6XIW |
| Chain | Residue | Details |
| A | ILE270-ALA289 | |
| A | PHE544-THR563 | |
| A | MET1105-ILE1124 | |
| A | ILE1379-CYS1398 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 27 |
| Details | TRANSMEM: Helical; Name=S6 of repeat I => ECO:0000269|PubMed:32698188, ECO:0007744|PDB:6XIW |
| Chain | Residue | Details |
| A | ARG295-ILE322 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=S1 of repeat II => ECO:0000269|PubMed:32698188, ECO:0007744|PDB:6XIW |
| Chain | Residue | Details |
| A | SER383-SER403 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=S2 of repeat II => ECO:0000269|PubMed:32698188, ECO:0007744|PDB:6XIW |
| Chain | Residue | Details |
| A | GLU417-CYS439 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=S3 of repeat II => ECO:0000269|PubMed:32698188, ECO:0007744|PDB:6XIW |
| Chain | Residue | Details |
| A | SER448-ASP468 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Voltage-sensor; Name=S4 of repeat II => ECO:0000269|PubMed:32698188, ECO:0007744|PDB:6XIW |
| Chain | Residue | Details |
| A | GLN473-LEU492 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 27 |
| Details | TRANSMEM: Helical; Name=S5 of repeat II => ECO:0000269|PubMed:32698188, ECO:0007744|PDB:6XIW |
| Chain | Residue | Details |
| A | GLY503-PHE530 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 29 |
| Details | TRANSMEM: Helical; Name=S6 of repeat II => ECO:0000269|PubMed:32698188, ECO:0007744|PDB:6XIW |
| Chain | Residue | Details |
| A | MET570-LEU599 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=S1 of repeat III => ECO:0000269|PubMed:32698188, ECO:0007744|PDB:6XIW |
| Chain | Residue | Details |
| A | TYR887-GLU906 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=S2 of repeat III => ECO:0000269|PubMed:32698188, ECO:0007744|PDB:6XIW |
| Chain | Residue | Details |
| A | PRO916-ALA939 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=S3 of repeat III => ECO:0000269|PubMed:32698188, ECO:0007744|PDB:6XIW |
| Chain | Residue | Details |
| A | ALA948-MET972 |
| site_id | SWS_FT_FI19 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Voltage-sensor; Name=S4 of repeat III => ECO:0000269|PubMed:32698188, ECO:0007744|PDB:6XIW |
| Chain | Residue | Details |
| A | GLY981-MET1003 |
| site_id | SWS_FT_FI20 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=S5 of repeat III => ECO:0000269|PubMed:32698188, ECO:0007744|PDB:6XIW |
| Chain | Residue | Details |
| A | GLU1016-PHE1039 |
| site_id | SWS_FT_FI21 |
| Number of Residues | 29 |
| Details | TRANSMEM: Helical; Name=S6 of repeat III => ECO:0000269|PubMed:32698188, ECO:0007744|PDB:6XIW |
| Chain | Residue | Details |
| A | PRO1130-PHE1159 |
| site_id | SWS_FT_FI22 |
| Number of Residues | 16 |
| Details | TRANSMEM: Helical; Name=S1 of repeat IV => ECO:0000269|PubMed:32698188, ECO:0007744|PDB:6XIW |
| Chain | Residue | Details |
| A | PHE1211-LEU1227 |
| site_id | SWS_FT_FI23 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=S2 of repeat IV => ECO:0000269|PubMed:32698188, ECO:0007744|PDB:6XIW |
| Chain | Residue | Details |
| A | VAL1237-ILE1260 |
| site_id | SWS_FT_FI24 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=S3 of repeat IV => ECO:0000269|PubMed:32698188, ECO:0007744|PDB:6XIW |
| Chain | Residue | Details |
| A | ARG1272-ALA1293 |
| site_id | SWS_FT_FI25 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Voltage-sensor; Name=S4 of repeat IV => ECO:0000269|PubMed:32698188, ECO:0007744|PDB:6XIW |
| Chain | Residue | Details |
| A | ALA1297-HIS1318 |
| site_id | SWS_FT_FI26 |
| Number of Residues | 25 |
| Details | TRANSMEM: Helical; Name=S5 of repeat IV => ECO:0000269|PubMed:32698188, ECO:0007744|PDB:6XIW |
| Chain | Residue | Details |
| A | MET1332-PHE1357 |
| site_id | SWS_FT_FI27 |
| Number of Residues | 26 |
| Details | TRANSMEM: Helical; Name=S6 of repeat IV => ECO:0000269|PubMed:32698188, ECO:0007744|PDB:6XIW |
| Chain | Residue | Details |
| A | ALA1421-VAL1447 |
| site_id | SWS_FT_FI28 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:33203861, ECO:0007744|PDB:7CM3 |
| Chain | Residue | Details |
| A | ASN210 | |
| A | ASN216 |
| site_id | SWS_FT_FI29 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:32698188, ECO:0000269|PubMed:33203861, ECO:0007744|PDB:6XIW, ECO:0007744|PDB:7CM3 |
| Chain | Residue | Details |
| A | ASN1064 |
