6XEV
CryoEM structure of GIRK2-PIP2/CHS - G protein-gated inwardly rectifying potassium channel GIRK2 with modulators cholesteryl hemisuccinate and PIP2
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005242 | molecular_function | inward rectifier potassium channel activity |
| A | 0006813 | biological_process | potassium ion transport |
| A | 0016020 | cellular_component | membrane |
| E | 0005242 | molecular_function | inward rectifier potassium channel activity |
| E | 0006813 | biological_process | potassium ion transport |
| E | 0016020 | cellular_component | membrane |
| I | 0005242 | molecular_function | inward rectifier potassium channel activity |
| I | 0006813 | biological_process | potassium ion transport |
| I | 0016020 | cellular_component | membrane |
| M | 0005242 | molecular_function | inward rectifier potassium channel activity |
| M | 0006813 | biological_process | potassium ion transport |
| M | 0016020 | cellular_component | membrane |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 96 |
| Details | TRANSMEM: Helical; Name=M1 => ECO:0000250 |
| Chain | Residue | Details |
| A | ARG92-ILE116 | |
| E | ARG92-ILE116 | |
| I | ARG92-ILE116 | |
| M | ARG92-ILE116 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 124 |
| Details | TOPO_DOM: Extracellular => ECO:0000250 |
| Chain | Residue | Details |
| A | ALA117-GLY140 | |
| A | ARG160-GLU168 | |
| E | ALA117-GLY140 | |
| E | ARG160-GLU168 | |
| I | ALA117-GLY140 | |
| I | ARG160-GLU168 | |
| M | ALA117-GLY140 | |
| M | ARG160-GLU168 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 44 |
| Details | INTRAMEM: Helical; Pore-forming; Name=H5 => ECO:0000250 |
| Chain | Residue | Details |
| A | PHE141-GLU152 | |
| E | PHE141-GLU152 | |
| I | PHE141-GLU152 | |
| M | PHE141-GLU152 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 24 |
| Details | INTRAMEM: Pore-forming => ECO:0000250 |
| Chain | Residue | Details |
| A | THR153-TYR159 | |
| E | THR153-TYR159 | |
| I | THR153-TYR159 | |
| M | THR153-TYR159 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 84 |
| Details | TRANSMEM: Helical; Name=M2 => ECO:0000250 |
| Chain | Residue | Details |
| A | GLY169-CYS190 | |
| E | GLY169-CYS190 | |
| I | GLY169-CYS190 | |
| M | GLY169-CYS190 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | SITE: Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesium => ECO:0000250 |
| Chain | Residue | Details |
| A | ASN184 | |
| E | ASN184 | |
| I | ASN184 | |
| M | ASN184 |
