Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | binding site for residue UQD A 301 |
| Chain | Residue |
| A | HIS56 |
| A | TRP220 |
| A | GLY221 |
| A | GLU222 |
| A | GLY231 |
| A | CIT305 |
| A | HOH473 |
| A | TYR101 |
| A | ASP194 |
| A | SER195 |
| A | CYS196 |
| A | GLN197 |
| A | SER200 |
| A | ILE218 |
| A | SER219 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | binding site for residue CIT A 302 |
| Chain | Residue |
| A | HIS103 |
| A | TYR180 |
| A | ASN181 |
| A | ASN182 |
| A | HIS189 |
| A | GLU190 |
| A | LYS227 |
| A | ARG238 |
| A | CIT303 |
| A | HOH434 |
| A | HOH504 |
| site_id | AC3 |
| Number of Residues | 11 |
| Details | binding site for residue CIT A 303 |
| Chain | Residue |
| A | ASN181 |
| A | ASN182 |
| A | HIS189 |
| A | LYS227 |
| A | CIT302 |
| A | HOH430 |
| A | HOH452 |
| A | HOH459 |
| A | HOH504 |
| A | HOH529 |
| A | HOH539 |
| site_id | AC4 |
| Number of Residues | 12 |
| Details | binding site for residue CIT A 304 |
| Chain | Residue |
| A | HIS91 |
| A | HIS92 |
| A | PHE188 |
| A | HIS189 |
| A | ARG238 |
| A | TYR239 |
| A | ASN241 |
| A | TRP242 |
| A | HOH405 |
| A | HOH412 |
| A | HOH425 |
| A | HOH433 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | binding site for residue CIT A 305 |
| Chain | Residue |
| A | ARG147 |
| A | HIS150 |
| A | LYS151 |
| A | GLN197 |
| A | GLU222 |
| A | CYS224 |
| A | UQD301 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 306 |
| Chain | Residue |
| A | ASN99 |
| A | TYR101 |
| A | PHE177 |
| A | THR178 |
| A | TRP220 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 307 |
| Chain | Residue |
| A | ASN93 |
| A | ASN95 |
| A | ASN99 |
| A | ASN102 |
| A | HIS103 |
| A | HOH438 |
Functional Information from PROSITE/UniProt
| site_id | PS00134 |
| Number of Residues | 6 |
| Details | TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VTAAHC |
| Chain | Residue | Details |
| A | VAL52-CYS57 | |
| site_id | PS00135 |
| Number of Residues | 12 |
| Details | TRYPSIN_SER Serine proteases, trypsin family, serine active site. DScqGDSGGPHV |
| Chain | Residue | Details |
| A | ASP194-VAL205 | |
| site_id | PS01186 |
| Number of Residues | 16 |
| Details | EGF_2 EGF-like domain signature 2. CsCteGYrlaenqksC |
| Chain | Residue | Details |
| B | CYS109-CYS124 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | SITE: Cleavage; by factor XIa |
| Chain | Residue | Details |
| B | ARG145 | |
| A | SER200 | |
| Chain | Residue | Details |
| A | ASP104 | |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10467148, ECO:0000269|PubMed:20004170, ECO:0000269|PubMed:20080729, ECO:0000269|PubMed:20121197, ECO:0000269|PubMed:20121198, ECO:0007744|PDB:1RFN, ECO:0007744|PDB:2WPH, ECO:0007744|PDB:2WPI, ECO:0007744|PDB:2WPJ, ECO:0007744|PDB:2WPK, ECO:0007744|PDB:2WPM, ECO:0007744|PDB:3KCG, ECO:0007744|PDB:3LC3, ECO:0007744|PDB:3LC5 |
| Chain | Residue | Details |
| A | GLU75 | |
| A | GLU77 | |
| A | GLU70 | |
| A | ASN72 | |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10467148, ECO:0000269|PubMed:20004170, ECO:0000269|PubMed:20080729, ECO:0000269|PubMed:20121197, ECO:0000269|PubMed:20121198, ECO:0007744|PDB:2WPH, ECO:0007744|PDB:2WPI, ECO:0007744|PDB:2WPJ, ECO:0007744|PDB:2WPK, ECO:0007744|PDB:2WPM, ECO:0007744|PDB:3KCG, ECO:0007744|PDB:3LC3, ECO:0007744|PDB:3LC5 |
| Chain | Residue | Details |
| A | GLU80 | |
