6X15
Inward-facing state of the glutamate transporter homologue GltPh in complex with L-aspartate and sodium ions
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005283 | molecular_function | amino acid:sodium symporter activity |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006835 | biological_process | dicarboxylic acid transport |
| A | 0006865 | biological_process | amino acid transport |
| A | 0015108 | molecular_function | chloride transmembrane transporter activity |
| A | 0015183 | molecular_function | L-aspartate transmembrane transporter activity |
| A | 0015293 | molecular_function | symporter activity |
| A | 0015501 | molecular_function | glutamate:sodium symporter activity |
| A | 0016020 | cellular_component | membrane |
| A | 0022857 | molecular_function | transmembrane transporter activity |
| A | 0035725 | biological_process | sodium ion transmembrane transport |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0046942 | biological_process | carboxylic acid transport |
| A | 0070207 | biological_process | protein homotrimerization |
| A | 0070778 | biological_process | L-aspartate transmembrane transport |
| A | 0140009 | biological_process | L-aspartate import across plasma membrane |
| A | 1902476 | biological_process | chloride transmembrane transport |
| B | 0005283 | molecular_function | amino acid:sodium symporter activity |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006835 | biological_process | dicarboxylic acid transport |
| B | 0006865 | biological_process | amino acid transport |
| B | 0015108 | molecular_function | chloride transmembrane transporter activity |
| B | 0015183 | molecular_function | L-aspartate transmembrane transporter activity |
| B | 0015293 | molecular_function | symporter activity |
| B | 0015501 | molecular_function | glutamate:sodium symporter activity |
| B | 0016020 | cellular_component | membrane |
| B | 0022857 | molecular_function | transmembrane transporter activity |
| B | 0035725 | biological_process | sodium ion transmembrane transport |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0046942 | biological_process | carboxylic acid transport |
| B | 0070207 | biological_process | protein homotrimerization |
| B | 0070778 | biological_process | L-aspartate transmembrane transport |
| B | 0140009 | biological_process | L-aspartate import across plasma membrane |
| B | 1902476 | biological_process | chloride transmembrane transport |
| C | 0005283 | molecular_function | amino acid:sodium symporter activity |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0006835 | biological_process | dicarboxylic acid transport |
| C | 0006865 | biological_process | amino acid transport |
| C | 0015108 | molecular_function | chloride transmembrane transporter activity |
| C | 0015183 | molecular_function | L-aspartate transmembrane transporter activity |
| C | 0015293 | molecular_function | symporter activity |
| C | 0015501 | molecular_function | glutamate:sodium symporter activity |
| C | 0016020 | cellular_component | membrane |
| C | 0022857 | molecular_function | transmembrane transporter activity |
| C | 0035725 | biological_process | sodium ion transmembrane transport |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0046942 | biological_process | carboxylic acid transport |
| C | 0070207 | biological_process | protein homotrimerization |
| C | 0070778 | biological_process | L-aspartate transmembrane transport |
| C | 0140009 | biological_process | L-aspartate import across plasma membrane |
| C | 1902476 | biological_process | chloride transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue NA A 501 |
| Chain | Residue |
| A | GLY306 |
| A | ASN310 |
| A | ASN401 |
| A | ASP405 |
| A | HOH602 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue NA A 502 |
| Chain | Residue |
| A | THR352 |
| A | THR308 |
| A | MET311 |
| A | SER349 |
| A | ILE350 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue NA A 503 |
| Chain | Residue |
| A | TYR89 |
| A | THR92 |
| A | SER93 |
| A | ASN310 |
| A | ASP312 |
| site_id | AC4 |
| Number of Residues | 12 |
| Details | binding site for residue ASP A 504 |
| Chain | Residue |
| A | ARG276 |
| A | SER277 |
| A | SER278 |
| A | THR314 |
| A | GLY354 |
| A | VAL355 |
| A | ALA358 |
| A | GLY359 |
| A | ASP394 |
| A | ARG397 |
| A | THR398 |
| A | ASN401 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue HG A 505 |
| Chain | Residue |
| A | LEU54 |
| A | CYS55 |
| A | CYS364 |
| A | TYR383 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | binding site for residue 6OU A 506 |
| Chain | Residue |
| A | LEU3 |
| A | TYR4 |
| A | TYR7 |
| A | ILE8 |
| A | PHE46 |
| A | LYS196 |
| A | GLY200 |
| B | TYR167 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue 6OU A 507 |
| Chain | Residue |
| A | PRO75 |
| A | TYR167 |
| C | FME1 |
| C | TYR4 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | binding site for residue 6OU A 508 |
| Chain | Residue |
| A | ALA127 |
| A | ILE133 |
| A | THR334 |
| A | VAL335 |
| A | GLY336 |
| A | GLN337 |
| A | THR340 |
| A | SER369 |
| site_id | AC9 |
| Number of Residues | 1 |
| Details | binding site for residue 6OU A 509 |
| Chain | Residue |
| A | ILE73 |
| site_id | AD1 |
| Number of Residues | 2 |
| Details | binding site for residue 6OU A 511 |
| Chain | Residue |
| A | PHE95 |
| A | TYR254 |
| site_id | AD2 |
| Number of Residues | 1 |
| Details | binding site for residue 6OU A 512 |
| Chain | Residue |
| A | TYR254 |
| site_id | AD3 |
| Number of Residues | 2 |
| Details | binding site for residue 6OU A 517 |
| Chain | Residue |
| A | PHE46 |
| A | PHE210 |
| site_id | AD4 |
| Number of Residues | 2 |
| Details | binding site for residue 6OU A 518 |
| Chain | Residue |
| A | LEU134 |
| C | PHE46 |
| site_id | AD5 |
| Number of Residues | 2 |
| Details | binding site for residue 6OU B 501 |
| Chain | Residue |
| A | PHE46 |
| B | LEU134 |
| site_id | AD6 |
| Number of Residues | 5 |
| Details | binding site for residue NA B 502 |
| Chain | Residue |
| B | GLY306 |
| B | ASN310 |
| B | ASN401 |
| B | ASP405 |
| B | HOH602 |
| site_id | AD7 |
| Number of Residues | 5 |
| Details | binding site for residue NA B 503 |
| Chain | Residue |
| B | THR308 |
| B | MET311 |
| B | SER349 |
| B | ILE350 |
| B | THR352 |
| site_id | AD8 |
| Number of Residues | 5 |
| Details | binding site for residue NA B 504 |
| Chain | Residue |
| B | TYR89 |
| B | THR92 |
| B | SER93 |
| B | ASN310 |
| B | ASP312 |
| site_id | AD9 |
| Number of Residues | 12 |
| Details | binding site for residue ASP B 505 |
| Chain | Residue |
| B | ARG276 |
| B | SER277 |
| B | SER278 |
| B | THR314 |
| B | GLY354 |
| B | VAL355 |
| B | ALA358 |
| B | GLY359 |
| B | ASP394 |
| B | ARG397 |
| B | THR398 |
| B | ASN401 |
| site_id | AE1 |
| Number of Residues | 4 |
| Details | binding site for residue HG B 506 |
| Chain | Residue |
| B | LEU54 |
| B | CYS55 |
| B | CYS364 |
| B | TYR383 |
| site_id | AE2 |
| Number of Residues | 8 |
| Details | binding site for residue 6OU B 507 |
| Chain | Residue |
| C | TYR167 |
| B | LEU3 |
| B | TYR4 |
| B | TYR7 |
| B | ILE8 |
| B | PHE46 |
| B | LYS196 |
| B | GLY200 |
| site_id | AE3 |
| Number of Residues | 3 |
| Details | binding site for residue 6OU B 508 |
| Chain | Residue |
| A | TYR4 |
| B | PRO75 |
| B | TYR167 |
| site_id | AE4 |
| Number of Residues | 8 |
| Details | binding site for residue 6OU B 509 |
| Chain | Residue |
| B | ALA127 |
| B | ILE133 |
| B | THR334 |
| B | VAL335 |
| B | GLY336 |
| B | GLN337 |
| B | THR340 |
| B | SER369 |
| site_id | AE5 |
| Number of Residues | 1 |
| Details | binding site for residue 6OU B 510 |
| Chain | Residue |
| B | ILE73 |
| site_id | AE6 |
| Number of Residues | 2 |
| Details | binding site for residue 6OU B 512 |
| Chain | Residue |
| B | PHE95 |
| B | TYR254 |
| site_id | AE7 |
| Number of Residues | 1 |
| Details | binding site for residue 6OU B 513 |
| Chain | Residue |
| B | TYR254 |
| site_id | AE8 |
| Number of Residues | 2 |
| Details | binding site for residue 6OU B 518 |
| Chain | Residue |
| B | PHE46 |
| B | PHE210 |
| site_id | AE9 |
| Number of Residues | 2 |
| Details | binding site for residue 6OU C 501 |
| Chain | Residue |
| B | PHE46 |
| C | LEU134 |
| site_id | AF1 |
| Number of Residues | 5 |
| Details | binding site for residue NA C 502 |
| Chain | Residue |
| C | GLY306 |
| C | ASN310 |
| C | ASN401 |
| C | ASP405 |
| C | HOH602 |
| site_id | AF2 |
| Number of Residues | 5 |
| Details | binding site for residue NA C 503 |
| Chain | Residue |
| C | THR308 |
| C | MET311 |
| C | SER349 |
| C | ILE350 |
| C | THR352 |
| site_id | AF3 |
| Number of Residues | 5 |
| Details | binding site for residue NA C 504 |
| Chain | Residue |
| C | TYR89 |
| C | THR92 |
| C | SER93 |
| C | ASN310 |
| C | ASP312 |
| site_id | AF4 |
| Number of Residues | 12 |
| Details | binding site for residue ASP C 505 |
| Chain | Residue |
| C | ARG276 |
| C | SER277 |
| C | SER278 |
| C | THR314 |
| C | GLY354 |
| C | VAL355 |
| C | ALA358 |
| C | GLY359 |
| C | ASP394 |
| C | ARG397 |
| C | THR398 |
| C | ASN401 |
| site_id | AF5 |
| Number of Residues | 4 |
| Details | binding site for residue HG C 506 |
| Chain | Residue |
| C | LEU54 |
| C | CYS55 |
| C | CYS364 |
| C | TYR383 |
| site_id | AF6 |
| Number of Residues | 8 |
| Details | binding site for residue 6OU C 507 |
| Chain | Residue |
| A | TYR167 |
| C | LEU3 |
| C | TYR4 |
| C | TYR7 |
| C | ILE8 |
| C | PHE46 |
| C | LYS196 |
| C | GLY200 |
| site_id | AF7 |
| Number of Residues | 3 |
| Details | binding site for residue 6OU C 508 |
| Chain | Residue |
| B | TYR4 |
| C | PRO75 |
| C | TYR167 |
| site_id | AF8 |
| Number of Residues | 8 |
| Details | binding site for residue 6OU C 509 |
| Chain | Residue |
| C | ALA127 |
| C | ILE133 |
| C | THR334 |
| C | VAL335 |
| C | GLY336 |
| C | GLN337 |
| C | THR340 |
| C | SER369 |
| site_id | AF9 |
| Number of Residues | 1 |
| Details | binding site for residue 6OU C 510 |
| Chain | Residue |
| C | ILE73 |
| site_id | AG1 |
| Number of Residues | 2 |
| Details | binding site for residue 6OU C 512 |
| Chain | Residue |
| C | PHE95 |
| C | TYR254 |
| site_id | AG2 |
| Number of Residues | 1 |
| Details | binding site for residue 6OU C 513 |
| Chain | Residue |
| C | TYR254 |
| site_id | AG3 |
| Number of Residues | 2 |
| Details | binding site for residue 6OU C 518 |
| Chain | Residue |
| C | PHE46 |
| C | PHE210 |
| site_id | AG4 |
| Number of Residues | 4 |
| Details | binding site for Di-peptide FME B 1 and GLY B 2 |
| Chain | Residue |
| B | LEU3 |
| B | TYR4 |
| B | ARG5 |
| B | LYS6 |
| site_id | AG5 |
| Number of Residues | 5 |
| Details | binding site for Di-peptide FME C 1 and GLY C 2 |
| Chain | Residue |
| A | 6OU507 |
| C | LEU3 |
| C | TYR4 |
| C | ARG5 |
| C | LYS6 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 231 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:15483603 |
| Chain | Residue | Details |
| A | FME1-PRO11 | |
| A | PHE63-ARG80 | |
| A | LEU161-LYS196 | |
| A | LYS252-SER260 | |
| A | LYS290-GLY297 | |
| B | FME1-PRO11 | |
| B | PHE63-ARG80 | |
| B | LEU161-LYS196 | |
| B | LYS252-SER260 | |
| B | LYS290-GLY297 | |
| C | FME1-PRO11 | |
| C | PHE63-ARG80 | |
| C | LEU161-LYS196 | |
| C | LYS252-SER260 | |
| C | LYS290-GLY297 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 54 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:15483603 |
| Chain | Residue | Details |
| A | VAL12-LEU30 | |
| B | VAL12-LEU30 | |
| C | VAL12-LEU30 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 216 |
| Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:15483603 |
| Chain | Residue | Details |
| A | GLY31-THR41 | |
| A | ALA104-GLN121 | |
| A | GLU219-LYS230 | |
| A | ALA321-GLN337 | |
| A | PRO373-ALA391 | |
| B | GLY31-THR41 | |
| B | ALA104-GLN121 | |
| B | GLU219-LYS230 | |
| B | ALA321-GLN337 | |
| B | PRO373-ALA391 | |
| C | GLY31-THR41 | |
| C | ALA104-GLN121 | |
| C | GLU219-LYS230 | |
| C | ALA321-GLN337 | |
| C | PRO373-ALA391 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 60 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:15483603 |
| Chain | Residue | Details |
| A | TYR42-VAL62 | |
| B | TYR42-VAL62 | |
| C | TYR42-VAL62 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 66 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:15483603 |
| Chain | Residue | Details |
| A | VAL81-MET103 | |
| B | VAL81-MET103 | |
| C | VAL81-MET103 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 114 |
| Details | TRANSMEM: Discontinuously helical; Name=4 => ECO:0000269|PubMed:15483603 |
| Chain | Residue | Details |
| A | PHE122-ILE160 | |
| B | PHE122-ILE160 | |
| C | PHE122-ILE160 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 63 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:15483603 |
| Chain | Residue | Details |
| A | ILE197-ALA218 | |
| B | ILE197-ALA218 | |
| C | ILE197-ALA218 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 60 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:15483603 |
| Chain | Residue | Details |
| A | VAL231-LEU251 | |
| B | VAL231-LEU251 | |
| C | VAL231-LEU251 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 186 |
| Details | INTRAMEM: Discontinuously helical => ECO:0000269|PubMed:15483603 |
| Chain | Residue | Details |
| A | PHE261-ALA289 | |
| A | GLN338-LEU372 | |
| B | PHE261-ALA289 | |
| B | GLN338-LEU372 | |
| C | PHE261-ALA289 | |
| C | GLN338-LEU372 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 66 |
| Details | TRANSMEM: Discontinuously helical; Name=7 => ECO:0000269|PubMed:15483603 |
| Chain | Residue | Details |
| A | ILE298-VAL320 | |
| B | ILE298-VAL320 | |
| C | ILE298-VAL320 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 60 |
| Details | TRANSMEM: Helical; Name=8 => ECO:0000269|PubMed:15483603 |
| Chain | Residue | Details |
| A | ILE392-VAL412 | |
| B | ILE392-VAL412 | |
| C | ILE392-VAL412 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17230192, ECO:0007744|PDB:2NWL, ECO:0007744|PDB:2NWX, ECO:0007744|PDB:3KBC |
| Chain | Residue | Details |
| B | VAL355 | |
| B | ASP394 | |
| C | ARG276 | |
| C | THR314 | |
| C | VAL355 | |
| C | ASP394 | |
| A | ARG276 | |
| A | THR314 | |
| A | VAL355 | |
| A | ASP394 | |
| B | ARG276 | |
| B | THR314 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 15 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:17230192, ECO:0007744|PDB:2NWX |
| Chain | Residue | Details |
| A | ASP405 | |
| B | THR308 | |
| B | THR352 | |
| B | ASN401 | |
| B | ASP405 | |
| C | GLY306 | |
| C | THR308 | |
| C | THR352 | |
| C | ASN401 | |
| C | ASP405 | |
| A | GLY306 | |
| A | THR308 | |
| A | THR352 | |
| A | ASN401 | |
| B | GLY306 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:17230192, ECO:0007744|PDB:2NWX, ECO:0007744|PDB:4X2S |
| Chain | Residue | Details |
| A | ASN310 | |
| B | ASN310 | |
| C | ASN310 |
