6WZ6
Complex of mutant (K173M) of Pseudomonas 7A Glutaminase-Asparaginase with L-Glu at pH 5. Covalent acyl-enzyme intermediate
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004067 | molecular_function | asparaginase activity |
A | 0004359 | molecular_function | glutaminase activity |
A | 0005829 | cellular_component | cytosol |
A | 0006520 | biological_process | amino acid metabolic process |
A | 0006528 | biological_process | asparagine metabolic process |
A | 0016787 | molecular_function | hydrolase activity |
A | 0042597 | cellular_component | periplasmic space |
A | 0050417 | molecular_function | glutamin-(asparagin-)ase activity |
B | 0004067 | molecular_function | asparaginase activity |
B | 0004359 | molecular_function | glutaminase activity |
B | 0005829 | cellular_component | cytosol |
B | 0006520 | biological_process | amino acid metabolic process |
B | 0006528 | biological_process | asparagine metabolic process |
B | 0016787 | molecular_function | hydrolase activity |
B | 0042597 | cellular_component | periplasmic space |
B | 0050417 | molecular_function | glutamin-(asparagin-)ase activity |
C | 0004067 | molecular_function | asparaginase activity |
C | 0004359 | molecular_function | glutaminase activity |
C | 0005829 | cellular_component | cytosol |
C | 0006520 | biological_process | amino acid metabolic process |
C | 0006528 | biological_process | asparagine metabolic process |
C | 0016787 | molecular_function | hydrolase activity |
C | 0042597 | cellular_component | periplasmic space |
C | 0050417 | molecular_function | glutamin-(asparagin-)ase activity |
D | 0004067 | molecular_function | asparaginase activity |
D | 0004359 | molecular_function | glutaminase activity |
D | 0005829 | cellular_component | cytosol |
D | 0006520 | biological_process | amino acid metabolic process |
D | 0006528 | biological_process | asparagine metabolic process |
D | 0016787 | molecular_function | hydrolase activity |
D | 0042597 | cellular_component | periplasmic space |
D | 0050417 | molecular_function | glutamin-(asparagin-)ase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 14 |
Details | binding site for residue GLU A 400 |
Chain | Residue |
A | GLY19 |
A | SER125 |
A | HOH583 |
A | HOH660 |
B | SER258 |
B | GLU294 |
A | THR20 |
A | TYR34 |
A | ALA66 |
A | SER67 |
A | GLU68 |
A | GLY99 |
A | THR100 |
A | ASP101 |
site_id | AC2 |
Number of Residues | 8 |
Details | binding site for residue EDO A 401 |
Chain | Residue |
A | THR116 |
A | ASP117 |
A | LYS118 |
A | GLY154 |
A | LYS155 |
A | GLY156 |
A | THR208 |
A | HOH623 |
site_id | AC3 |
Number of Residues | 10 |
Details | binding site for residue EDO C 401 |
Chain | Residue |
C | THR116 |
C | ASP117 |
C | GLY154 |
C | LYS155 |
C | GLY156 |
C | HIS207 |
C | THR208 |
C | VAL209 |
C | HOH517 |
C | HOH588 |
site_id | AC4 |
Number of Residues | 3 |
Details | binding site for residue EDO D 401 |
Chain | Residue |
D | ARG206 |
D | GLU212 |
D | ARG332 |
site_id | AC5 |
Number of Residues | 18 |
Details | binding site for Di-peptide GLU B 400 and THR B 20 |
Chain | Residue |
A | SER258 |
A | GLU294 |
B | GLY19 |
B | ILE21 |
B | ALA22 |
B | GLY23 |
B | TYR34 |
B | ALA66 |
B | SER67 |
B | GLU68 |
B | GLY99 |
B | THR100 |
B | ASP101 |
B | SER125 |
B | ARG127 |
B | PRO128 |
B | HOH612 |
B | HOH642 |
site_id | AC6 |
Number of Residues | 18 |
Details | binding site for Di-peptide GLU C 400 and THR C 20 |
Chain | Residue |
C | GLY19 |
C | ILE21 |
C | ALA22 |
C | GLY23 |
C | TYR34 |
C | ALA66 |
C | SER67 |
C | GLU68 |
C | GLY99 |
C | THR100 |
C | ASP101 |
C | SER125 |
C | ARG127 |
C | PRO128 |
C | HOH579 |
C | HOH651 |
D | SER258 |
D | GLU294 |
site_id | AC7 |
Number of Residues | 18 |
Details | binding site for Di-peptide GLU D 400 and THR D 20 |
Chain | Residue |
C | SER258 |
C | GLU294 |
D | GLY19 |
D | ILE21 |
D | ALA22 |
D | GLY23 |
D | TYR34 |
D | ALA66 |
D | SER67 |
D | GLU68 |
D | GLY99 |
D | THR100 |
D | ASP101 |
D | SER125 |
D | ARG127 |
D | PRO128 |
D | HOH589 |
D | HOH643 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | ACT_SITE: Acyl-ester intermediate => ECO:0000255|PROSITE-ProRule:PRU10099, ECO:0000255|PROSITE-ProRule:PRU10100 |
Chain | Residue | Details |
B | THR20 | |
C | THR20 | |
D | THR20 | |
A | THR20 |
site_id | SWS_FT_FI2 |
Number of Residues | 8 |
Details | BINDING: BINDING => ECO:0000250 |
Chain | Residue | Details |
C | SER67 | |
C | THR100 | |
D | SER67 | |
D | THR100 | |
A | THR100 | |
B | SER67 | |
B | THR100 | |
A | SER67 |