6WW4
Crystal structure of HERC2 ZZ domain in complex with histone H3 tail
Functional Information from GO Data
Functional Information from PROSITE/UniProt
| site_id | PS01357 |
| Number of Residues | 28 |
| Details | ZF_ZZ_1 Zinc finger ZZ-type signature. CdgCqmfpingsRFkCrn...CdDFdFCetC |
| Chain | Residue | Details |
| B | CYS2708-CYS2735 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | MOD_RES: Citrulline; alternate => ECO:0000269|PubMed:16567635 |
| Chain | Residue | Details |
| A | ARG2 | |
| B | ARG2 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine; by HASPIN and VRK1 => ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:31527692 |
| Chain | Residue | Details |
| A | THR3 | |
| B | THR3 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708 |
| Chain | Residue | Details |
| A | LYS4 | |
| B | LYS4 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: 5-glutamyl serotonin; alternate => ECO:0000269|PubMed:30867594 |
| Chain | Residue | Details |
| A | GLN5 | |
| B | GLN5 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine; by PKC => ECO:0000269|PubMed:20228790 |
| Chain | Residue | Details |
| A | THR6 | |
| B | THR6 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 16 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00228 |
| Chain | Residue | Details |
| A | CYS2708 | |
| A | CYS2711 | |
| A | CYS2723 | |
| A | CYS2726 | |
| A | CYS2732 | |
| A | CYS2735 | |
| A | HIS2741 | |
| A | HIS2745 | |
| B | CYS2732 | |
| B | CYS2735 | |
| B | HIS2741 | |
| B | HIS2745 | |
| B | CYS2708 | |
| B | CYS2711 | |
| B | CYS2723 | |
| B | CYS2726 |
