6WV4
Human VKOR C43S with warfarin
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0006091 | biological_process | generation of precursor metabolites and energy |
| A | 0006805 | biological_process | xenobiotic metabolic process |
| A | 0007596 | biological_process | blood coagulation |
| A | 0008218 | biological_process | bioluminescence |
| A | 0010243 | biological_process | response to organonitrogen compound |
| A | 0014070 | biological_process | response to organic cyclic compound |
| A | 0016020 | cellular_component | membrane |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016728 | molecular_function | oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor |
| A | 0017187 | biological_process | peptidyl-glutamic acid carboxylation |
| A | 0030193 | biological_process | regulation of blood coagulation |
| A | 0042373 | biological_process | vitamin K metabolic process |
| A | 0047057 | molecular_function | vitamin-K-epoxide reductase (warfarin-sensitive) activity |
| A | 0047058 | molecular_function | vitamin-K-epoxide reductase (warfarin-insensitive) activity |
| A | 0048038 | molecular_function | quinone binding |
| A | 0050820 | biological_process | positive regulation of coagulation |
| A | 0060348 | biological_process | bone development |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 81 |
| Details | TRANSMEM: Helical => ECO:0000269|PubMed:33154105, ECO:0007744|PDB:6WV3, ECO:0007744|PDB:6WV4, ECO:0007744|PDB:6WV5, ECO:0007744|PDB:6WV6, ECO:0007744|PDB:6WV7, ECO:0007744|PDB:6WVH |
| Chain | Residue | Details |
| A | TRP152-VAL171 | |
| A | SER223-GLY237 | |
| A | TRP243-LEU270 | |
| A | CYS274-VAL295 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 52 |
| Details | TOPO_DOM: Lumenal => ECO:0000269|PubMed:33154105 |
| Chain | Residue | Details |
| A | LYS172-ASN222 | |
| A | TYR271-PHE273 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:33154105 |
| Chain | Residue | Details |
| A | CYS238-ARG242 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:33154105, ECO:0007744|PDB:6WV3, ECO:0007744|PDB:6WV4 |
| Chain | Residue | Details |
| A | ASN222 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:33154105, ECO:0007744|PDB:6WV5 |
| Chain | Residue | Details |
| A | CYS277 | |
| A | TYR281 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: (Z)-2,3-didehydrotyrosine => ECO:0000269|PubMed:8448132 |
| Chain | Residue | Details |
| A | VAL68 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | CROSSLNK: 5-imidazolinone (Ser-Gly) => ECO:0000269|PubMed:8448132 |
| Chain | Residue | Details |
| A | CRO66 | |
| A | GLN69 |
