Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6W6G

The Mycobacterium tuberculosis ClpB disaggregase hexamer structure in conformation I in the presence of DnaK chaperone and a model substrate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005886	cellular_component	plasma membrane
A	0009274	cellular_component	peptidoglycan-based cell wall
A	0009408	biological_process	response to heat
A	0016887	molecular_function	ATP hydrolysis activity
A	0034605	biological_process	cellular response to heat
A	0042026	biological_process	protein refolding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005886	cellular_component	plasma membrane
B	0009274	cellular_component	peptidoglycan-based cell wall
B	0009408	biological_process	response to heat
B	0016887	molecular_function	ATP hydrolysis activity
B	0034605	biological_process	cellular response to heat
B	0042026	biological_process	protein refolding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005886	cellular_component	plasma membrane
C	0009274	cellular_component	peptidoglycan-based cell wall
C	0009408	biological_process	response to heat
C	0016887	molecular_function	ATP hydrolysis activity
C	0034605	biological_process	cellular response to heat
C	0042026	biological_process	protein refolding
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005886	cellular_component	plasma membrane
D	0009274	cellular_component	peptidoglycan-based cell wall
D	0009408	biological_process	response to heat
D	0016887	molecular_function	ATP hydrolysis activity
D	0034605	biological_process	cellular response to heat
D	0042026	biological_process	protein refolding
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0005886	cellular_component	plasma membrane
E	0009274	cellular_component	peptidoglycan-based cell wall
E	0009408	biological_process	response to heat
E	0016887	molecular_function	ATP hydrolysis activity
E	0034605	biological_process	cellular response to heat
E	0042026	biological_process	protein refolding
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0005886	cellular_component	plasma membrane
F	0009274	cellular_component	peptidoglycan-based cell wall
F	0009408	biological_process	response to heat
F	0016887	molecular_function	ATP hydrolysis activity
F	0034605	biological_process	cellular response to heat
F	0042026	biological_process	protein refolding

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue AGS A 901

Chain	Residue
A	PRO179
A	LEU354
B	ARG332
B	ARG333
A	VAL180
A	ILE181
A	GLY209
A	GLY211
A	LYS212
A	THR213
A	ALA214
A	ILE350

site_id	AC2
Number of Residues	12
Details	binding site for residue AGS A 902

Chain	Residue
A	ARG571
A	ILE573
A	THR609
A	GLY610
A	VAL611
A	GLY612
A	LYS613
A	THR614
A	GLN768
A	ARG805
A	ARG808
B	ARG746

site_id	AC3
Number of Residues	11
Details	binding site for residue AGS B 901

Chain	Residue
B	PRO179
B	VAL180
B	ILE181
B	GLY209
B	GLY211
B	LYS212
B	THR213
B	LEU354
B	ILE392
C	ARG332
C	ARG333

site_id	AC4
Number of Residues	12
Details	binding site for residue AGS B 902

Chain	Residue
B	ARG571
B	ILE573
B	THR609
B	GLY610
B	VAL611
B	GLY612
B	LYS613
B	THR614
B	GLU615
B	ARG805
B	ARG808
C	ARG746

site_id	AC5
Number of Residues	12
Details	binding site for residue AGS C 901

Chain	Residue
C	ARG571
C	ILE573
C	THR609
C	GLY610
C	VAL611
C	GLY612
C	LYS613
C	THR614
C	GLU615
C	GLN768
C	ARG805
D	ARG746

site_id	AC6
Number of Residues	11
Details	binding site for residue AGS D 901

Chain	Residue
C	PRO179
C	VAL180
C	ILE181
C	GLY209
C	GLY211
C	LYS212
C	THR213
C	ILE350
C	LEU354
D	ARG332
D	ARG333

site_id	AC7
Number of Residues	10
Details	binding site for residue AGS D 902

Chain	Residue
D	VAL180
D	ILE181
D	GLY209
D	GLY211
D	LYS212
D	THR213
D	ALA214
D	LEU354
D	ILE392
E	ARG332

site_id	AC8
Number of Residues	12
Details	binding site for residue AGS D 903

Chain	Residue
D	ARG571
D	VAL572
D	ILE573
D	GLY610
D	VAL611
D	GLY612
D	LYS613
D	THR614
D	GLU615
D	GLN768
D	ALA804
D	ARG805

site_id	AC9
Number of Residues	12
Details	binding site for residue AGS E 901

Chain	Residue
E	THR213
E	ALA214
E	ILE350
E	PRO388
F	ARG332
E	PRO179
E	VAL180
E	ILE181
E	GLY209
E	VAL210
E	GLY211
E	LYS212

site_id	AD1
Number of Residues	12
Details	binding site for residue ADP E 902

Chain	Residue
E	ARG571
E	VAL572
E	ILE573
E	THR609
E	GLY610
E	VAL611
E	GLY612
E	LYS613
E	THR614
E	GLU615
E	ALA804
E	ARG805

site_id	AD2
Number of Residues	13
Details	binding site for residue AGS F 901

Chain	Residue
A	GLU742
A	ARG746
F	ARG571
F	VAL572
F	ILE573
F	THR609
F	VAL611
F	GLY612
F	LYS613
F	THR614
F	GLU615
F	ALA804
F	ARG805

site_id	AD3
Number of Residues	12
Details	binding site for residue ADP F 902

Chain	Residue
F	VAL180
F	GLU207
F	PRO208
F	GLY209
F	VAL210
F	GLY211
F	LYS212
F	THR213
F	ALA214
F	ILE350
F	PRO388
F	ASP389

Functional Information from PROSITE/UniProt

site_id	PS00870
Number of Residues	13
Details	CLPAB_1 Chaperonins clpA/B signature 1. DAGNMIKPmLarG

Chain	Residue	Details
A	ASP295-GLY307

site_id	PS00871
Number of Residues	19
Details	CLPAB_2 Chaperonins clpA/B signature 2. RIDmSEYgEKhTvARLiGA

Chain	Residue	Details
A	ARG633-ALA651

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	GLY206
E	GLY607
F	GLY206
F	GLY607
A	GLY607
B	GLY206
B	GLY607
C	GLY206
C	GLY607
D	GLY206
D	GLY607
E	GLY206

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)