6VX7
bestrophin-2 Ca2+-bound state (5 mM Ca2+)
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue CA C 501 |
| Chain | Residue |
| B | ALA10 |
| B | HOH602 |
| C | GLN293 |
| C | ASN296 |
| C | ASP301 |
| C | ASP304 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue CA A 502 |
| Chain | Residue |
| A | ASP304 |
| E | ALA10 |
| E | HOH602 |
| A | GLN293 |
| A | ASN296 |
| A | ASP301 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue CA B 501 |
| Chain | Residue |
| A | ALA10 |
| A | HOH602 |
| B | GLN293 |
| B | ASN296 |
| B | ASP301 |
| B | ASP304 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue CA E 501 |
| Chain | Residue |
| D | ALA10 |
| D | HOH602 |
| E | GLN293 |
| E | ASN296 |
| E | ASP301 |
| E | ASP304 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue CA D 501 |
| Chain | Residue |
| C | ALA10 |
| C | HOH602 |
| D | GLN293 |
| D | ASN296 |
| D | ASP301 |
| D | ASP304 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 925 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305 |
| Chain | Residue | Details |
| C | MET1-LEU31 | |
| D | GLY83-GLN238 | |
| C | GLY83-GLN238 | |
| A | MET1-LEU31 | |
| A | GLY83-GLN238 | |
| B | MET1-LEU31 | |
| B | GLY83-GLN238 | |
| E | MET1-LEU31 | |
| E | GLY83-GLN238 | |
| D | MET1-LEU31 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 345 |
| Details | TRANSMEM: Helical => ECO:0000269|PubMed:32251414, ECO:0000269|PubMed:35789156, ECO:0000269|PubMed:36289327, ECO:0007744|PDB:6VX5, ECO:0007744|PDB:6VX6, ECO:0007744|PDB:6VX7, ECO:0007744|PDB:6VX8, ECO:0007744|PDB:6VX9, ECO:0007744|PDB:8D1N, ECO:0007744|PDB:8ECY |
| Chain | Residue | Details |
| C | LEU32-ARG51 | |
| B | TYR61-LEU82 | |
| B | VAL239-ARG255 | |
| B | ILE275-LEU288 | |
| E | LEU32-ARG51 | |
| E | TYR61-LEU82 | |
| E | VAL239-ARG255 | |
| E | ILE275-LEU288 | |
| D | LEU32-ARG51 | |
| D | TYR61-LEU82 | |
| D | VAL239-ARG255 | |
| C | TYR61-LEU82 | |
| D | ILE275-LEU288 | |
| C | VAL239-ARG255 | |
| C | ILE275-LEU288 | |
| A | LEU32-ARG51 | |
| A | TYR61-LEU82 | |
| A | VAL239-ARG255 | |
| A | ILE275-LEU288 | |
| B | LEU32-ARG51 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 130 |
| Details | TOPO_DOM: Extracellular => ECO:0000305 |
| Chain | Residue | Details |
| C | PHE52-ARG60 | |
| D | GLN256-PRO274 | |
| C | GLN256-PRO274 | |
| A | PHE52-ARG60 | |
| A | GLN256-PRO274 | |
| B | PHE52-ARG60 | |
| B | GLN256-PRO274 | |
| E | PHE52-ARG60 | |
| E | GLN256-PRO274 | |
| D | PHE52-ARG60 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 5 |
| Details | BINDING: in other chain => ECO:0000269|PubMed:32251414, ECO:0000269|PubMed:35789156, ECO:0000269|PubMed:36289327, ECO:0007744|PDB:6VX5, ECO:0007744|PDB:6VX6, ECO:0007744|PDB:6VX7, ECO:0007744|PDB:6VX8, ECO:0007744|PDB:6VX9, ECO:0007744|PDB:8D1N, ECO:0007744|PDB:8ECY |
| Chain | Residue | Details |
| C | ALA10 | |
| A | ALA10 | |
| B | ALA10 | |
| E | ALA10 | |
| D | ALA10 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 20 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:32251414, ECO:0000269|PubMed:35789156, ECO:0000269|PubMed:36289327, ECO:0007744|PDB:6VX5, ECO:0007744|PDB:6VX6, ECO:0007744|PDB:6VX7, ECO:0007744|PDB:6VX8, ECO:0007744|PDB:6VX9, ECO:0007744|PDB:8D1N, ECO:0007744|PDB:8ECY |
| Chain | Residue | Details |
| C | GLN293 | |
| B | ASN296 | |
| B | ASP301 | |
| B | ASP304 | |
| E | GLN293 | |
| E | ASN296 | |
| E | ASP301 | |
| E | ASP304 | |
| D | GLN293 | |
| D | ASN296 | |
| D | ASP301 | |
| C | ASN296 | |
| D | ASP304 | |
| C | ASP301 | |
| C | ASP304 | |
| A | GLN293 | |
| A | ASN296 | |
| A | ASP301 | |
| A | ASP304 | |
| B | GLN293 |
