Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6VCU

Homo sapiens FKBP12 protein bound with APX879 in P32 space group

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000413	biological_process	protein peptidyl-prolyl isomerization
A	0003007	biological_process	heart morphogenesis
A	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
A	0005160	molecular_function	transforming growth factor beta receptor binding
A	0005515	molecular_function	protein binding
A	0005527	molecular_function	macrolide binding
A	0005528	molecular_function	FK506 binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006457	biological_process	protein folding
A	0006458	biological_process	'de novo' protein folding
A	0014802	cellular_component	terminal cisterna
A	0014809	biological_process	regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
A	0016020	cellular_component	membrane
A	0016247	molecular_function	channel regulator activity
A	0016529	cellular_component	sarcoplasmic reticulum
A	0022417	biological_process	protein maturation by protein folding
A	0030018	cellular_component	Z disc
A	0030512	biological_process	negative regulation of transforming growth factor beta receptor signaling pathway
A	0030547	molecular_function	signaling receptor inhibitor activity
A	0032092	biological_process	positive regulation of protein binding
A	0032880	biological_process	regulation of protein localization
A	0032926	biological_process	negative regulation of activin receptor signaling pathway
A	0033017	cellular_component	sarcoplasmic reticulum membrane
A	0034713	molecular_function	type I transforming growth factor beta receptor binding
A	0042026	biological_process	protein refolding
A	0042110	biological_process	T cell activation
A	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
A	0044325	molecular_function	transmembrane transporter binding
A	0050776	biological_process	regulation of immune response
A	0055010	biological_process	ventricular cardiac muscle tissue morphogenesis
A	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
A	0060347	biological_process	heart trabecula formation
A	0070411	molecular_function	I-SMAD binding
A	0070588	biological_process	calcium ion transmembrane transport
A	0070697	molecular_function	activin receptor binding
A	0097435	biological_process	supramolecular fiber organization
A	0098562	cellular_component	cytoplasmic side of membrane
A	1902991	biological_process	regulation of amyloid precursor protein catabolic process
A	1990000	biological_process	amyloid fibril formation
A	1990425	cellular_component	ryanodine receptor complex
B	0000413	biological_process	protein peptidyl-prolyl isomerization
B	0003007	biological_process	heart morphogenesis
B	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
B	0005160	molecular_function	transforming growth factor beta receptor binding
B	0005515	molecular_function	protein binding
B	0005527	molecular_function	macrolide binding
B	0005528	molecular_function	FK506 binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006457	biological_process	protein folding
B	0006458	biological_process	'de novo' protein folding
B	0014802	cellular_component	terminal cisterna
B	0014809	biological_process	regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
B	0016020	cellular_component	membrane
B	0016247	molecular_function	channel regulator activity
B	0016529	cellular_component	sarcoplasmic reticulum
B	0022417	biological_process	protein maturation by protein folding
B	0030018	cellular_component	Z disc
B	0030512	biological_process	negative regulation of transforming growth factor beta receptor signaling pathway
B	0030547	molecular_function	signaling receptor inhibitor activity
B	0032092	biological_process	positive regulation of protein binding
B	0032880	biological_process	regulation of protein localization
B	0032926	biological_process	negative regulation of activin receptor signaling pathway
B	0033017	cellular_component	sarcoplasmic reticulum membrane
B	0034713	molecular_function	type I transforming growth factor beta receptor binding
B	0042026	biological_process	protein refolding
B	0042110	biological_process	T cell activation
B	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
B	0044325	molecular_function	transmembrane transporter binding
B	0050776	biological_process	regulation of immune response
B	0055010	biological_process	ventricular cardiac muscle tissue morphogenesis
B	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
B	0060347	biological_process	heart trabecula formation
B	0070411	molecular_function	I-SMAD binding
B	0070588	biological_process	calcium ion transmembrane transport
B	0070697	molecular_function	activin receptor binding
B	0097435	biological_process	supramolecular fiber organization
B	0098562	cellular_component	cytoplasmic side of membrane
B	1902991	biological_process	regulation of amyloid precursor protein catabolic process
B	1990000	biological_process	amyloid fibril formation
B	1990425	cellular_component	ryanodine receptor complex
C	0000413	biological_process	protein peptidyl-prolyl isomerization
C	0003007	biological_process	heart morphogenesis
C	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
C	0005160	molecular_function	transforming growth factor beta receptor binding
C	0005515	molecular_function	protein binding
C	0005527	molecular_function	macrolide binding
C	0005528	molecular_function	FK506 binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006457	biological_process	protein folding
C	0006458	biological_process	'de novo' protein folding
C	0014802	cellular_component	terminal cisterna
C	0014809	biological_process	regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
C	0016020	cellular_component	membrane
C	0016247	molecular_function	channel regulator activity
C	0016529	cellular_component	sarcoplasmic reticulum
C	0022417	biological_process	protein maturation by protein folding
C	0030018	cellular_component	Z disc
C	0030512	biological_process	negative regulation of transforming growth factor beta receptor signaling pathway
C	0030547	molecular_function	signaling receptor inhibitor activity
C	0032092	biological_process	positive regulation of protein binding
C	0032880	biological_process	regulation of protein localization
C	0032926	biological_process	negative regulation of activin receptor signaling pathway
C	0033017	cellular_component	sarcoplasmic reticulum membrane
C	0034713	molecular_function	type I transforming growth factor beta receptor binding
C	0042026	biological_process	protein refolding
C	0042110	biological_process	T cell activation
C	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
C	0044325	molecular_function	transmembrane transporter binding
C	0050776	biological_process	regulation of immune response
C	0055010	biological_process	ventricular cardiac muscle tissue morphogenesis
C	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
C	0060347	biological_process	heart trabecula formation
C	0070411	molecular_function	I-SMAD binding
C	0070588	biological_process	calcium ion transmembrane transport
C	0070697	molecular_function	activin receptor binding
C	0097435	biological_process	supramolecular fiber organization
C	0098562	cellular_component	cytoplasmic side of membrane
C	1902991	biological_process	regulation of amyloid precursor protein catabolic process
C	1990000	biological_process	amyloid fibril formation
C	1990425	cellular_component	ryanodine receptor complex
D	0000413	biological_process	protein peptidyl-prolyl isomerization
D	0003007	biological_process	heart morphogenesis
D	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
D	0005160	molecular_function	transforming growth factor beta receptor binding
D	0005515	molecular_function	protein binding
D	0005527	molecular_function	macrolide binding
D	0005528	molecular_function	FK506 binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006457	biological_process	protein folding
D	0006458	biological_process	'de novo' protein folding
D	0014802	cellular_component	terminal cisterna
D	0014809	biological_process	regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
D	0016020	cellular_component	membrane
D	0016247	molecular_function	channel regulator activity
D	0016529	cellular_component	sarcoplasmic reticulum
D	0022417	biological_process	protein maturation by protein folding
D	0030018	cellular_component	Z disc
D	0030512	biological_process	negative regulation of transforming growth factor beta receptor signaling pathway
D	0030547	molecular_function	signaling receptor inhibitor activity
D	0032092	biological_process	positive regulation of protein binding
D	0032880	biological_process	regulation of protein localization
D	0032926	biological_process	negative regulation of activin receptor signaling pathway
D	0033017	cellular_component	sarcoplasmic reticulum membrane
D	0034713	molecular_function	type I transforming growth factor beta receptor binding
D	0042026	biological_process	protein refolding
D	0042110	biological_process	T cell activation
D	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
D	0044325	molecular_function	transmembrane transporter binding
D	0050776	biological_process	regulation of immune response
D	0055010	biological_process	ventricular cardiac muscle tissue morphogenesis
D	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
D	0060347	biological_process	heart trabecula formation
D	0070411	molecular_function	I-SMAD binding
D	0070588	biological_process	calcium ion transmembrane transport
D	0070697	molecular_function	activin receptor binding
D	0097435	biological_process	supramolecular fiber organization
D	0098562	cellular_component	cytoplasmic side of membrane
D	1902991	biological_process	regulation of amyloid precursor protein catabolic process
D	1990000	biological_process	amyloid fibril formation
D	1990425	cellular_component	ryanodine receptor complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue ACT A 201

Chain	Residue
A	VAL4
A	GLU5
A	THR6
A	HOH388
B	PRO93

site_id	AC2
Number of Residues	4
Details	binding site for residue ACT A 202

Chain	Residue
A	GLY1
A	VAL2
A	TYR80
A	HOH385

site_id	AC3
Number of Residues	23
Details	binding site for residue R27 A 203

Chain	Residue
A	TYR26
A	PHE36
A	ASP37
A	ARG42
A	PHE46
A	GLU54
A	VAL55
A	ILE56
A	TRP59
A	ALA81
A	TYR82
A	ILE91
A	PHE99
A	HOH311
B	R27203
C	TYR82
C	THR85
C	GLY86
C	HIS87
D	PRO88
D	R27202
D	HOH322
D	HOH352

site_id	AC4
Number of Residues	5
Details	binding site for residue ACT B 201

Chain	Residue
A	PRO93
B	VAL4
B	GLU5
B	THR6
B	HOH372

site_id	AC5
Number of Residues	3
Details	binding site for residue ACT B 202

Chain	Residue
B	GLY1
B	VAL2
B	TYR80

site_id	AC6
Number of Residues	22
Details	binding site for residue R27 B 203

Chain	Residue
A	R27203
B	TYR26
B	PHE36
B	ASP37
B	ARG42
B	PHE46
B	GLU54
B	VAL55
B	ILE56
B	TRP59
B	ALA81
B	TYR82
B	ILE91
B	PHE99
B	HOH314
B	HOH325
C	PRO88
C	R27201
D	TYR82
D	THR85
D	GLY86
D	HIS87

site_id	AC7
Number of Residues	22
Details	binding site for residue R27 C 201

Chain	Residue
A	TYR82
A	THR85
A	GLY86
A	HIS87
B	HIS87
B	PRO88
B	R27203
B	HOH325
C	TYR26
C	PHE36
C	ASP37
C	ARG42
C	PHE46
C	GLU54
C	VAL55
C	ILE56
C	TRP59
C	ALA81
C	TYR82
C	ILE91
C	PHE99
D	R27202

site_id	AC8
Number of Residues	6
Details	binding site for residue ACT D 201

Chain	Residue
D	HIS25
D	ASN43
D	PRO45
D	HOH308
D	HOH333
D	HOH389

site_id	AC9
Number of Residues	22
Details	binding site for residue R27 D 202

Chain	Residue
D	PHE36
D	ASP37
D	ARG42
D	PHE46
D	GLU54
D	VAL55
D	ILE56
D	TRP59
D	ALA81
D	TYR82
D	PHE99
D	HOH322
D	HOH352
A	HIS87
A	PRO88
A	R27203
B	TYR82
B	THR85
B	GLY86
B	HIS87
C	R27201
D	TYR26

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250\|UniProtKB:P26883

Chain	Residue	Details
B	LYS52
C	LYS52
D	LYS52
A	LYS52

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	6
Details	M-CSA 362

Chain	Residue	Details
A	TYR26	electrostatic destabiliser, steric role
A	PHE36	electrostatic destabiliser, polar/non-polar interaction, steric role
A	ASP37	electrostatic stabiliser, steric role
A	ILE56	electrostatic stabiliser, steric role
A	TYR82	electrostatic stabiliser, steric role
A	PHE99	electrostatic destabiliser, polar/non-polar interaction, steric role

site_id	MCSA2
Number of Residues	6
Details	M-CSA 362

Chain	Residue	Details
B	TYR26	electrostatic destabiliser, steric role
B	PHE36	electrostatic destabiliser, polar/non-polar interaction, steric role
B	ASP37	electrostatic stabiliser, steric role
B	ILE56	electrostatic stabiliser, steric role
B	TYR82	electrostatic stabiliser, steric role
B	PHE99	electrostatic destabiliser, polar/non-polar interaction, steric role

site_id	MCSA3
Number of Residues	6
Details	M-CSA 362

Chain	Residue	Details
C	TYR26	electrostatic destabiliser, steric role
C	PHE36	electrostatic destabiliser, polar/non-polar interaction, steric role
C	ASP37	electrostatic stabiliser, steric role
C	ILE56	electrostatic stabiliser, steric role
C	TYR82	electrostatic stabiliser, steric role
C	PHE99	electrostatic destabiliser, polar/non-polar interaction, steric role

site_id	MCSA4
Number of Residues	6
Details	M-CSA 362

Chain	Residue	Details
D	TYR26	electrostatic destabiliser, steric role
D	PHE36	electrostatic destabiliser, polar/non-polar interaction, steric role
D	ASP37	electrostatic stabiliser, steric role
D	ILE56	electrostatic stabiliser, steric role
D	TYR82	electrostatic stabiliser, steric role
D	PHE99	electrostatic destabiliser, polar/non-polar interaction, steric role

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)