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6UZZ

structure of human KCNQ1-CaM complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0005216molecular_functionmonoatomic ion channel activity
A0005249molecular_functionvoltage-gated potassium channel activity
A0006811biological_processmonoatomic ion transport
A0006813biological_processpotassium ion transport
A0008076cellular_componentvoltage-gated potassium channel complex
A0016020cellular_componentmembrane
A0055085biological_processtransmembrane transport
B0000086biological_processG2/M transition of mitotic cell cycle
B0000922cellular_componentspindle pole
B0002027biological_processregulation of heart rate
B0005509molecular_functioncalcium ion binding
B0005513biological_processdetection of calcium ion
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005813cellular_componentcentrosome
B0005819cellular_componentspindle
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0005876cellular_componentspindle microtubule
B0005886cellular_componentplasma membrane
B0007186biological_processG protein-coupled receptor signaling pathway
B0008076cellular_componentvoltage-gated potassium channel complex
B0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
B0010801biological_processnegative regulation of peptidyl-threonine phosphorylation
B0010856molecular_functionadenylate cyclase activator activity
B0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
B0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
B0016020cellular_componentmembrane
B0016240biological_processautophagosome membrane docking
B0019855molecular_functioncalcium channel inhibitor activity
B0019901molecular_functionprotein kinase binding
B0021762biological_processsubstantia nigra development
B0030017cellular_componentsarcomere
B0031432molecular_functiontitin binding
B0031514cellular_componentmotile cilium
B0031954biological_processpositive regulation of protein autophosphorylation
B0031982cellular_componentvesicle
B0032465biological_processregulation of cytokinesis
B0032516biological_processpositive regulation of phosphoprotein phosphatase activity
B0032991cellular_componentprotein-containing complex
B0034704cellular_componentcalcium channel complex
B0035307biological_processpositive regulation of protein dephosphorylation
B0035458biological_processcellular response to interferon-beta
B0043209cellular_componentmyelin sheath
B0043539molecular_functionprotein serine/threonine kinase activator activity
B0044325molecular_functiontransmembrane transporter binding
B0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
B0046872molecular_functionmetal ion binding
B0048306molecular_functioncalcium-dependent protein binding
B0050848biological_processregulation of calcium-mediated signaling
B0051343biological_processpositive regulation of cyclic-nucleotide phosphodiesterase activity
B0051592biological_processresponse to calcium ion
B0055117biological_processregulation of cardiac muscle contraction
B0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
B0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
B0060316biological_processpositive regulation of ryanodine-sensitive calcium-release channel activity
B0071346biological_processcellular response to type II interferon
B0071902biological_processpositive regulation of protein serine/threonine kinase activity
B0072542molecular_functionprotein phosphatase activator activity
B0097225cellular_componentsperm midpiece
B0098901biological_processregulation of cardiac muscle cell action potential
B0140056biological_processorganelle localization by membrane tethering
B1901842biological_processnegative regulation of high voltage-gated calcium channel activity
B1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
B1902494cellular_componentcatalytic complex
B1905913biological_processnegative regulation of calcium ion export across plasma membrane
B1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
C0005216molecular_functionmonoatomic ion channel activity
C0005249molecular_functionvoltage-gated potassium channel activity
C0006811biological_processmonoatomic ion transport
C0006813biological_processpotassium ion transport
C0008076cellular_componentvoltage-gated potassium channel complex
C0016020cellular_componentmembrane
C0055085biological_processtransmembrane transport
D0000086biological_processG2/M transition of mitotic cell cycle
D0000922cellular_componentspindle pole
D0002027biological_processregulation of heart rate
D0005509molecular_functioncalcium ion binding
D0005513biological_processdetection of calcium ion
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005813cellular_componentcentrosome
D0005819cellular_componentspindle
D0005829cellular_componentcytosol
D0005856cellular_componentcytoskeleton
D0005876cellular_componentspindle microtubule
D0005886cellular_componentplasma membrane
D0007186biological_processG protein-coupled receptor signaling pathway
D0008076cellular_componentvoltage-gated potassium channel complex
D0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
D0010801biological_processnegative regulation of peptidyl-threonine phosphorylation
D0010856molecular_functionadenylate cyclase activator activity
D0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
D0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
D0016020cellular_componentmembrane
D0016240biological_processautophagosome membrane docking
D0019855molecular_functioncalcium channel inhibitor activity
D0019901molecular_functionprotein kinase binding
D0021762biological_processsubstantia nigra development
D0030017cellular_componentsarcomere
D0031432molecular_functiontitin binding
D0031514cellular_componentmotile cilium
D0031954biological_processpositive regulation of protein autophosphorylation
D0031982cellular_componentvesicle
D0032465biological_processregulation of cytokinesis
D0032516biological_processpositive regulation of phosphoprotein phosphatase activity
D0032991cellular_componentprotein-containing complex
D0034704cellular_componentcalcium channel complex
D0035307biological_processpositive regulation of protein dephosphorylation
D0035458biological_processcellular response to interferon-beta
D0043209cellular_componentmyelin sheath
D0043539molecular_functionprotein serine/threonine kinase activator activity
D0044325molecular_functiontransmembrane transporter binding
D0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
D0046872molecular_functionmetal ion binding
D0048306molecular_functioncalcium-dependent protein binding
D0050848biological_processregulation of calcium-mediated signaling
D0051343biological_processpositive regulation of cyclic-nucleotide phosphodiesterase activity
D0051592biological_processresponse to calcium ion
D0055117biological_processregulation of cardiac muscle contraction
D0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
D0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
D0060316biological_processpositive regulation of ryanodine-sensitive calcium-release channel activity
D0071346biological_processcellular response to type II interferon
D0071902biological_processpositive regulation of protein serine/threonine kinase activity
D0072542molecular_functionprotein phosphatase activator activity
D0097225cellular_componentsperm midpiece
D0098901biological_processregulation of cardiac muscle cell action potential
D0140056biological_processorganelle localization by membrane tethering
D1901842biological_processnegative regulation of high voltage-gated calcium channel activity
D1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
D1902494cellular_componentcatalytic complex
D1905913biological_processnegative regulation of calcium ion export across plasma membrane
D1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
E0005216molecular_functionmonoatomic ion channel activity
E0005249molecular_functionvoltage-gated potassium channel activity
E0006811biological_processmonoatomic ion transport
E0006813biological_processpotassium ion transport
E0008076cellular_componentvoltage-gated potassium channel complex
E0016020cellular_componentmembrane
E0055085biological_processtransmembrane transport
F0000086biological_processG2/M transition of mitotic cell cycle
F0000922cellular_componentspindle pole
F0002027biological_processregulation of heart rate
F0005509molecular_functioncalcium ion binding
F0005513biological_processdetection of calcium ion
F0005515molecular_functionprotein binding
F0005576cellular_componentextracellular region
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005737cellular_componentcytoplasm
F0005813cellular_componentcentrosome
F0005819cellular_componentspindle
F0005829cellular_componentcytosol
F0005856cellular_componentcytoskeleton
F0005876cellular_componentspindle microtubule
F0005886cellular_componentplasma membrane
F0007186biological_processG protein-coupled receptor signaling pathway
F0008076cellular_componentvoltage-gated potassium channel complex
F0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
F0010801biological_processnegative regulation of peptidyl-threonine phosphorylation
F0010856molecular_functionadenylate cyclase activator activity
F0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
F0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
F0016020cellular_componentmembrane
F0016240biological_processautophagosome membrane docking
F0019855molecular_functioncalcium channel inhibitor activity
F0019901molecular_functionprotein kinase binding
F0021762biological_processsubstantia nigra development
F0030017cellular_componentsarcomere
F0031432molecular_functiontitin binding
F0031514cellular_componentmotile cilium
F0031954biological_processpositive regulation of protein autophosphorylation
F0031982cellular_componentvesicle
F0032465biological_processregulation of cytokinesis
F0032516biological_processpositive regulation of phosphoprotein phosphatase activity
F0032991cellular_componentprotein-containing complex
F0034704cellular_componentcalcium channel complex
F0035307biological_processpositive regulation of protein dephosphorylation
F0035458biological_processcellular response to interferon-beta
F0043209cellular_componentmyelin sheath
F0043539molecular_functionprotein serine/threonine kinase activator activity
F0044325molecular_functiontransmembrane transporter binding
F0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
F0046872molecular_functionmetal ion binding
F0048306molecular_functioncalcium-dependent protein binding
F0050848biological_processregulation of calcium-mediated signaling
F0051343biological_processpositive regulation of cyclic-nucleotide phosphodiesterase activity
F0051592biological_processresponse to calcium ion
F0055117biological_processregulation of cardiac muscle contraction
F0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
F0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
F0060316biological_processpositive regulation of ryanodine-sensitive calcium-release channel activity
F0071346biological_processcellular response to type II interferon
F0071902biological_processpositive regulation of protein serine/threonine kinase activity
F0072542molecular_functionprotein phosphatase activator activity
F0097225cellular_componentsperm midpiece
F0098901biological_processregulation of cardiac muscle cell action potential
F0140056biological_processorganelle localization by membrane tethering
F1901842biological_processnegative regulation of high voltage-gated calcium channel activity
F1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
F1902494cellular_componentcatalytic complex
F1905913biological_processnegative regulation of calcium ion export across plasma membrane
F1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
G0005216molecular_functionmonoatomic ion channel activity
G0005249molecular_functionvoltage-gated potassium channel activity
G0006811biological_processmonoatomic ion transport
G0006813biological_processpotassium ion transport
G0008076cellular_componentvoltage-gated potassium channel complex
G0016020cellular_componentmembrane
G0055085biological_processtransmembrane transport
H0000086biological_processG2/M transition of mitotic cell cycle
H0000922cellular_componentspindle pole
H0002027biological_processregulation of heart rate
H0005509molecular_functioncalcium ion binding
H0005513biological_processdetection of calcium ion
H0005515molecular_functionprotein binding
H0005576cellular_componentextracellular region
H0005634cellular_componentnucleus
H0005654cellular_componentnucleoplasm
H0005737cellular_componentcytoplasm
H0005813cellular_componentcentrosome
H0005819cellular_componentspindle
H0005829cellular_componentcytosol
H0005856cellular_componentcytoskeleton
H0005876cellular_componentspindle microtubule
H0005886cellular_componentplasma membrane
H0007186biological_processG protein-coupled receptor signaling pathway
H0008076cellular_componentvoltage-gated potassium channel complex
H0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
H0010801biological_processnegative regulation of peptidyl-threonine phosphorylation
H0010856molecular_functionadenylate cyclase activator activity
H0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
H0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
H0016020cellular_componentmembrane
H0016240biological_processautophagosome membrane docking
H0019855molecular_functioncalcium channel inhibitor activity
H0019901molecular_functionprotein kinase binding
H0021762biological_processsubstantia nigra development
H0030017cellular_componentsarcomere
H0031432molecular_functiontitin binding
H0031514cellular_componentmotile cilium
H0031954biological_processpositive regulation of protein autophosphorylation
H0031982cellular_componentvesicle
H0032465biological_processregulation of cytokinesis
H0032516biological_processpositive regulation of phosphoprotein phosphatase activity
H0032991cellular_componentprotein-containing complex
H0034704cellular_componentcalcium channel complex
H0035307biological_processpositive regulation of protein dephosphorylation
H0035458biological_processcellular response to interferon-beta
H0043209cellular_componentmyelin sheath
H0043539molecular_functionprotein serine/threonine kinase activator activity
H0044325molecular_functiontransmembrane transporter binding
H0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
H0046872molecular_functionmetal ion binding
H0048306molecular_functioncalcium-dependent protein binding
H0050848biological_processregulation of calcium-mediated signaling
H0051343biological_processpositive regulation of cyclic-nucleotide phosphodiesterase activity
H0051592biological_processresponse to calcium ion
H0055117biological_processregulation of cardiac muscle contraction
H0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
H0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
H0060316biological_processpositive regulation of ryanodine-sensitive calcium-release channel activity
H0071346biological_processcellular response to type II interferon
H0071902biological_processpositive regulation of protein serine/threonine kinase activity
H0072542molecular_functionprotein phosphatase activator activity
H0097225cellular_componentsperm midpiece
H0098901biological_processregulation of cardiac muscle cell action potential
H0140056biological_processorganelle localization by membrane tethering
H1901842biological_processnegative regulation of high voltage-gated calcium channel activity
H1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
H1902494cellular_componentcatalytic complex
H1905913biological_processnegative regulation of calcium ion export across plasma membrane
H1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
Functional Information from PDB Data
site_idAC1
Number of Residues5
Detailsbinding site for residue CA B 201
ChainResidue
BASP21
BASP23
BASP25
BTHR27
BGLU32

site_idAC2
Number of Residues5
Detailsbinding site for residue CA B 202
ChainResidue
BGLU68
BASP57
BASP59
BASN61
BTHR63

site_idAC3
Number of Residues5
Detailsbinding site for residue CA D 201
ChainResidue
DASP21
DASP23
DASP25
DTHR27
DGLU32

site_idAC4
Number of Residues5
Detailsbinding site for residue CA D 202
ChainResidue
DASP57
DASP59
DASN61
DTHR63
DGLU68

site_idAC5
Number of Residues5
Detailsbinding site for residue CA F 201
ChainResidue
FASP21
FASP23
FASP25
FTHR27
FGLU32

site_idAC6
Number of Residues5
Detailsbinding site for residue CA F 202
ChainResidue
FASP57
FASP59
FASN61
FTHR63
FGLU68

site_idAC7
Number of Residues5
Detailsbinding site for residue CA H 201
ChainResidue
HASP21
HASP23
HASP25
HTHR27
HGLU32

site_idAC8
Number of Residues5
Detailsbinding site for residue CA H 202
ChainResidue
HASP57
HASP59
HASN61
HTHR63
HGLU68

Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DKDGDGTITtkEL
ChainResidueDetails
BASP21-LEU33
BASP57-PHE69
BASP94-LEU106
BASP130-PHE142

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues40
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:1474585, ECO:0000269|PubMed:25441029, ECO:0000269|PubMed:27564677, ECO:0007744|PDB:1CLL, ECO:0007744|PDB:4UMO, ECO:0007744|PDB:4V0C, ECO:0007744|PDB:5J03
ChainResidueDetails
BGLU32
BASP21
BASP23
BASP25
BTHR27
FASP21
FASP23
FASP25
FTHR27
FGLU32
FASP57
FASP59
FASN61
FTHR63
FGLU68
HASP21
HASP23
HASP25
HTHR27
HGLU32
HASP57
HASP59
HASN61
HTHR63
HGLU68
BASP57
BASP59
BASN61
BTHR63
BGLU68
DASP21
DASP23
DASP25
DTHR27
DGLU32
DASP57
DASP59
DASN61
DTHR63
DGLU68

site_idSWS_FT_FI2
Number of Residues40
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:1474585, ECO:0000269|PubMed:27564677, ECO:0007744|PDB:1CLL, ECO:0007744|PDB:5J03
ChainResidueDetails
FASP94
FASP96
FASN98
FTYR100
FGLU105
FASP130
FASP132
FASP134
FGLN136
FGLU141
HASP94
HASP96
HASN98
HTYR100
HGLU105
HASP130
HASP132
HASP134
HGLN136
HGLU141
BASP94
BASP96
BASN98
BTYR100
BGLU105
BASP130
BASP132
BASP134
BGLN136
BGLU141
DASP94
DASP96
DASN98
DTYR100
DGLU105
DASP130
DASP132
DASP134
DGLN136
DGLU141

site_idSWS_FT_FI3
Number of Residues4
DetailsMOD_RES: N-acetylalanine => ECO:0000269|PubMed:7093203, ECO:0000269|Ref.7, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378, ECO:0007744|PubMed:25944712
ChainResidueDetails
BALA2
DALA2
FALA2
HALA2

site_idSWS_FT_FI4
Number of Residues4
DetailsMOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861
ChainResidueDetails
BLYS22
DLYS22
FLYS22
HLYS22
ETHR169-LYS196
EARG249-GLU261
GTHR169-LYS196
GARG249-GLU261

site_idSWS_FT_FI5
Number of Residues4
DetailsMOD_RES: Phosphothreonine; by CaMK4 => ECO:0000250|UniProtKB:P0DP29
ChainResidueDetails
BTHR45
DTHR45
FTHR45
HTHR45

site_idSWS_FT_FI6
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
BSER82
DSER82
FSER82
HSER82

site_idSWS_FT_FI7
Number of Residues4
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
BLYS95
DLYS95
FLYS95
HLYS95

site_idSWS_FT_FI8
Number of Residues4
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332
ChainResidueDetails
BTYR100
DTYR100
FTYR100
HTYR100

site_idSWS_FT_FI9
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
BSER102
DSER102
FSER102
HSER102

site_idSWS_FT_FI10
Number of Residues4
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569
ChainResidueDetails
BTHR111
DTHR111
FTHR111
HTHR111
ESER407
ESER409
GSER407
GSER409

site_idSWS_FT_FI11
Number of Residues4
DetailsMOD_RES: N6-methyllysine; alternate => ECO:0007744|PubMed:24129315
ChainResidueDetails
BLYS116
DLYS116
FLYS116
HLYS116

site_idSWS_FT_FI12
Number of Residues4
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:19690332
ChainResidueDetails
BTYR139
DTYR139
FTYR139
HTYR139

site_idSWS_FT_FI13
Number of Residues8
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P62157
ChainResidueDetails
FLYS22
HLYS22
BLYS22
DLYS22

219869

PDB entries from 2024-05-15

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