Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6UZ8

Cryo-EM structure of human TRPC6 in complex with agonist AM-0883

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0005261	molecular_function	monoatomic cation channel activity
A	0005262	molecular_function	calcium channel activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006812	biological_process	monoatomic cation transport
A	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
A	0007338	biological_process	single fertilization
A	0015279	molecular_function	store-operated calcium channel activity
A	0016020	cellular_component	membrane
A	0032414	biological_process	positive regulation of ion transmembrane transporter activity
A	0034703	cellular_component	cation channel complex
A	0036057	cellular_component	slit diaphragm
A	0042803	molecular_function	protein homodimerization activity
A	0051480	biological_process	regulation of cytosolic calcium ion concentration
A	0051928	biological_process	positive regulation of calcium ion transport
A	0055085	biological_process	transmembrane transport
A	0070588	biological_process	calcium ion transmembrane transport
A	0070679	molecular_function	inositol 1,4,5 trisphosphate binding
B	0005216	molecular_function	monoatomic ion channel activity
B	0005261	molecular_function	monoatomic cation channel activity
B	0005262	molecular_function	calcium channel activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0006812	biological_process	monoatomic cation transport
B	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
B	0007338	biological_process	single fertilization
B	0015279	molecular_function	store-operated calcium channel activity
B	0016020	cellular_component	membrane
B	0032414	biological_process	positive regulation of ion transmembrane transporter activity
B	0034703	cellular_component	cation channel complex
B	0036057	cellular_component	slit diaphragm
B	0042803	molecular_function	protein homodimerization activity
B	0051480	biological_process	regulation of cytosolic calcium ion concentration
B	0051928	biological_process	positive regulation of calcium ion transport
B	0055085	biological_process	transmembrane transport
B	0070588	biological_process	calcium ion transmembrane transport
B	0070679	molecular_function	inositol 1,4,5 trisphosphate binding
C	0005216	molecular_function	monoatomic ion channel activity
C	0005261	molecular_function	monoatomic cation channel activity
C	0005262	molecular_function	calcium channel activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0006812	biological_process	monoatomic cation transport
C	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
C	0007338	biological_process	single fertilization
C	0015279	molecular_function	store-operated calcium channel activity
C	0016020	cellular_component	membrane
C	0032414	biological_process	positive regulation of ion transmembrane transporter activity
C	0034703	cellular_component	cation channel complex
C	0036057	cellular_component	slit diaphragm
C	0042803	molecular_function	protein homodimerization activity
C	0051480	biological_process	regulation of cytosolic calcium ion concentration
C	0051928	biological_process	positive regulation of calcium ion transport
C	0055085	biological_process	transmembrane transport
C	0070588	biological_process	calcium ion transmembrane transport
C	0070679	molecular_function	inositol 1,4,5 trisphosphate binding
D	0005216	molecular_function	monoatomic ion channel activity
D	0005261	molecular_function	monoatomic cation channel activity
D	0005262	molecular_function	calcium channel activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005886	cellular_component	plasma membrane
D	0006811	biological_process	monoatomic ion transport
D	0006812	biological_process	monoatomic cation transport
D	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
D	0007338	biological_process	single fertilization
D	0015279	molecular_function	store-operated calcium channel activity
D	0016020	cellular_component	membrane
D	0032414	biological_process	positive regulation of ion transmembrane transporter activity
D	0034703	cellular_component	cation channel complex
D	0036057	cellular_component	slit diaphragm
D	0042803	molecular_function	protein homodimerization activity
D	0051480	biological_process	regulation of cytosolic calcium ion concentration
D	0051928	biological_process	positive regulation of calcium ion transport
D	0055085	biological_process	transmembrane transport
D	0070588	biological_process	calcium ion transmembrane transport
D	0070679	molecular_function	inositol 1,4,5 trisphosphate binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue SBM A 1001

Chain	Residue
A	GLU524
A	TRP526
A	ALA611
A	TYR612
A	GLN624
A	GLY628
A	VAL631

site_id	AC2
Number of Residues	9
Details	binding site for residue Y01 A 1002

Chain	Residue
A	MET403
A	LYS406
A	PHE407
A	PHE440
A	THR451
A	ALA616
A	ASN617
A	TRP391
A	TYR392

site_id	AC3
Number of Residues	6
Details	binding site for residue R0D A 1003

Chain	Residue
A	TYR705
A	GLY709
D	GLU672
D	PHE675
D	PHE679
D	TRP680

site_id	AC4
Number of Residues	3
Details	binding site for residue Y01 A 1004

Chain	Residue
A	LYS698
A	PHE699
A	ASN702

site_id	AC5
Number of Residues	7
Details	binding site for residue SBM D 1001

Chain	Residue
D	GLU524
D	TRP526
D	ALA611
D	TYR612
D	GLN624
D	GLY628
D	VAL631

site_id	AC6
Number of Residues	9
Details	binding site for residue Y01 D 1002

Chain	Residue
D	TRP391
D	TYR392
D	MET403
D	LYS406
D	PHE407
D	PHE440
D	THR451
D	ALA616
D	ASN617

site_id	AC7
Number of Residues	6
Details	binding site for residue R0D D 1003

Chain	Residue
C	GLU672
C	PHE675
C	PHE679
C	TRP680
D	TYR705
D	GLY709

site_id	AC8
Number of Residues	3
Details	binding site for residue Y01 D 1004

Chain	Residue
D	LYS698
D	PHE699
D	ASN702

site_id	AC9
Number of Residues	6
Details	binding site for residue R0D B 1001

Chain	Residue
A	GLU672
A	PHE675
A	PHE679
A	TRP680
B	TYR705
B	GLY709

site_id	AD1
Number of Residues	3
Details	binding site for residue Y01 B 1002

Chain	Residue
B	LYS698
B	PHE699
B	ASN702

site_id	AD2
Number of Residues	7
Details	binding site for residue SBM B 1003

Chain	Residue
B	GLU524
B	TRP526
B	ALA611
B	TYR612
B	GLN624
B	GLY628
B	VAL631

site_id	AD3
Number of Residues	9
Details	binding site for residue Y01 B 1004

Chain	Residue
B	TRP391
B	TYR392
B	MET403
B	LYS406
B	PHE407
B	PHE440
B	THR451
B	ALA616
B	ASN617

site_id	AD4
Number of Residues	6
Details	binding site for residue R0D C 1001

Chain	Residue
B	GLU672
B	PHE675
B	PHE679
B	TRP680
C	TYR705
C	GLY709

site_id	AD5
Number of Residues	3
Details	binding site for residue Y01 C 1002

Chain	Residue
C	LYS698
C	PHE699
C	ASN702

site_id	AD6
Number of Residues	7
Details	binding site for residue SBM C 1003

Chain	Residue
C	GLU524
C	TRP526
C	ALA611
C	TYR612
C	GLN624
C	GLY628
C	VAL631

site_id	AD7
Number of Residues	9
Details	binding site for residue Y01 C 1004

Chain	Residue
C	ASN617
C	TRP391
C	TYR392
C	MET403
C	LYS406
C	PHE407
C	PHE440
C	THR451
C	ALA616

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	480
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
C	ILE593-ILE613
A	PRO439-MET459
A	THR488-ALA508
A	LEU522-ILE542
A	ILE593-ILE613
A	PHE637-SER657
A	LEU707-ILE727
D	PRO439-MET459
D	THR488-ALA508
D	LEU522-ILE542
D	ILE593-ILE613
D	PHE637-SER657
D	LEU707-ILE727
B	PRO439-MET459
B	THR488-ALA508
B	LEU522-ILE542
B	ILE593-ILE613
B	PHE637-SER657
B	LEU707-ILE727
C	PRO439-MET459
C	THR488-ALA508
C	LEU522-ILE542
C	PHE637-SER657
C	LEU707-ILE727

site_id	SWS_FT_FI2
Number of Residues	496
Details	TOPO_DOM: Extracellular => ECO:0000255

Chain	Residue	Details
A	ASN460-LYS487
A	ALA543-GLN592
A	TYR658-VAL706
D	ASN460-LYS487
D	ALA543-GLN592
D	TYR658-VAL706
B	ASN460-LYS487
B	ALA543-GLN592
B	TYR658-VAL706
C	ASN460-LYS487
C	ALA543-GLN592
C	TYR658-VAL706

site_id	SWS_FT_FI3
Number of Residues	948
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
C	LEU614-LYS636
A	GLU509-TYR521
A	LEU614-LYS636
A	ASN728-ARG931
D	GLU509-TYR521
D	LEU614-LYS636
D	ASN728-ARG931
B	GLU509-TYR521
B	LEU614-LYS636
B	ASN728-ARG931
C	GLU509-TYR521
C	ASN728-ARG931

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:18088087

Chain	Residue	Details
D	SER815
B	SER815
C	SER815
A	SER815

site_id	SWS_FT_FI5
Number of Residues	8
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:12970363

Chain	Residue	Details
D	ASN473
D	ASN561
B	ASN473
B	ASN561
C	ASN473
C	ASN561
A	ASN473
A	ASN561

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)