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6UML

Structural Basis for Thalidomide Teratogenicity Revealed by the Cereblon-DDB1-SALL4-Pomalidomide Complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000781cellular_componentchromosome, telomeric region
A0003676molecular_functionnucleic acid binding
A0003677molecular_functionDNA binding
A0003684molecular_functiondamaged DNA binding
A0005515molecular_functionprotein binding
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005730cellular_componentnucleolus
A0005737cellular_componentcytoplasm
A0006281biological_processDNA repair
A0006289biological_processnucleotide-excision repair
A0006511biological_processubiquitin-dependent protein catabolic process
A0006915biological_processapoptotic process
A0006974biological_processDNA damage response
A0007056biological_processspindle assembly involved in female meiosis
A0010498biological_processproteasomal protein catabolic process
A0016055biological_processWnt signaling pathway
A0016567biological_processprotein ubiquitination
A0019076biological_processviral release from host cell
A0030674molecular_functionprotein-macromolecule adaptor activity
A0031464cellular_componentCul4A-RING E3 ubiquitin ligase complex
A0031465cellular_componentCul4B-RING E3 ubiquitin ligase complex
A0032991cellular_componentprotein-containing complex
A0034644biological_processcellular response to UV
A0035234biological_processectopic germ cell programmed cell death
A0035861cellular_componentsite of double-strand break
A0042752biological_processregulation of circadian rhythm
A0043066biological_processnegative regulation of apoptotic process
A0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
A0044725biological_processepigenetic programming in the zygotic pronuclei
A0044877molecular_functionprotein-containing complex binding
A0045070biological_processpositive regulation of viral genome replication
A0045722biological_processpositive regulation of gluconeogenesis
A0045732biological_processpositive regulation of protein catabolic process
A0046726biological_processpositive regulation by virus of viral protein levels in host cell
A0048511biological_processrhythmic process
A0051093biological_processnegative regulation of developmental process
A0051702biological_processbiological process involved in interaction with symbiont
A0070062cellular_componentextracellular exosome
A0070914biological_processUV-damage excision repair
A0071987molecular_functionWD40-repeat domain binding
A0080008cellular_componentCul4-RING E3 ubiquitin ligase complex
A0097602molecular_functioncullin family protein binding
A0160072molecular_functionubiquitin ligase complex scaffold activity
A1901990biological_processregulation of mitotic cell cycle phase transition
A2000242biological_processnegative regulation of reproductive process
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0016020cellular_componentmembrane
C0016567biological_processprotein ubiquitination
C0030177biological_processpositive regulation of Wnt signaling pathway
C0031333biological_processnegative regulation of protein-containing complex assembly
C0031334biological_processpositive regulation of protein-containing complex assembly
C0031464cellular_componentCul4A-RING E3 ubiquitin ligase complex
C0034766biological_processnegative regulation of monoatomic ion transmembrane transport
C0035641biological_processlocomotory exploration behavior
C0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
C0044325molecular_functiontransmembrane transporter binding
C0046872molecular_functionmetal ion binding
C0048471cellular_componentperinuclear region of cytoplasm
Functional Information from PDB Data
site_idAC1
Number of Residues4
Detailsbinding site for residue ZN C 501
ChainResidue
CCYS323
CCYS326
CCYS391
CCYS394

site_idAC2
Number of Residues13
Detailsbinding site for residue Y70 C 502
ChainResidue
CTRP380
CTRP386
CPHE402
EVAL411
ECYS412
EVAL414
ECYS415
EGLY416
CASN351
CPRO352
CHIS353
CGLU377
CHIS378

site_idAC3
Number of Residues4
Detailsbinding site for residue ZN E 501
ChainResidue
ECYS412
ECYS415
EHIS428
EHIS432

Functional Information from PROSITE/UniProt
site_idPS00028
Number of Residues21
DetailsZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. Csv..CghrFttkgnlkvHfhr..H
ChainResidueDetails
ECYS412-HIS432

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues22
DetailsZN_FING: C2H2-type 3 => ECO:0000255|PROSITE-ProRule:PRU00042
ChainResidueDetails
EPHE410-HIS432
CCYS326
CHIS378
CTRP380
CTRP386
CCYS391
CCYS394

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS1067

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q9ESW0
ChainResidueDetails
ATHR1125

site_idSWS_FT_FI4
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
ALYS1121

220113

PDB entries from 2024-05-22

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