6UKN
Cryo-EM structure of the potassium-chloride cotransporter KCC4 in lipid nanodiscs
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006813 | biological_process | potassium ion transport |
| A | 0006884 | biological_process | cell volume homeostasis |
| A | 0007268 | biological_process | chemical synaptic transmission |
| A | 0008519 | molecular_function | ammonium transmembrane transporter activity |
| A | 0015293 | molecular_function | symporter activity |
| A | 0015377 | molecular_function | chloride:monoatomic cation symporter activity |
| A | 0015379 | molecular_function | potassium:chloride symporter activity |
| A | 0016020 | cellular_component | membrane |
| A | 0019901 | molecular_function | protein kinase binding |
| A | 0022857 | molecular_function | transmembrane transporter activity |
| A | 0032991 | cellular_component | protein-containing complex |
| A | 0045202 | cellular_component | synapse |
| A | 0046873 | molecular_function | metal ion transmembrane transporter activity |
| A | 0055064 | biological_process | chloride ion homeostasis |
| A | 0055075 | biological_process | potassium ion homeostasis |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0071333 | biological_process | cellular response to glucose stimulus |
| A | 0071805 | biological_process | potassium ion transmembrane transport |
| A | 0098662 | biological_process | inorganic cation transmembrane transport |
| A | 0140157 | biological_process | ammonium import across plasma membrane |
| A | 1902476 | biological_process | chloride transmembrane transport |
| A | 1990573 | biological_process | potassium ion import across plasma membrane |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 455 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| A | MET1-MET118 | |
| A | THR162-ALA200 | |
| A | ASN274-LYS275 | |
| A | GLY437-ILE456 | |
| A | THR515-GLU553 | |
| A | GLN599-SER624 | |
| A | ARG866-SER1083 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 240 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| A | GLY119-LEU139 | |
| A | LEU141-CYS161 | |
| A | VAL201-ILE221 | |
| A | VAL253-VAL273 | |
| A | LEU276-ILE296 | |
| A | ILE416-ALA436 | |
| A | LEU457-ILE477 | |
| A | LEU494-SER514 | |
| A | PRO554-LEU574 | |
| A | ALA578-VAL598 | |
| A | LEU625-ALA645 | |
| A | ASN845-LEU865 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19144319 |
| Chain | Residue | Details |
| A | SER30 | |
| A | SER33 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:19144319 |
| Chain | Residue | Details |
| A | THR37 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:17242355, ECO:0007744|PubMed:19144319, ECO:0007744|PubMed:21183079 |
| Chain | Residue | Details |
| A | SER50 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9Y666 |
| Chain | Residue | Details |
| A | SER62 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:21183079 |
| Chain | Residue | Details |
| A | THR973 | |
| A | THR980 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) (high mannose) asparagine => ECO:0000269|PubMed:23376777 |
| Chain | Residue | Details |
| A | ASN312 | |
| A | ASN360 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:19349973, ECO:0000269|PubMed:19656770, ECO:0000269|PubMed:23376777 |
| Chain | Residue | Details |
| A | ASN331 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:23376777 |
| Chain | Residue | Details |
| A | ASN344 |
