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6UC0

Isolated S3D-cofilin bound to an actin filament

Functional Information from GO Data
ChainGOidnamespacecontents
A0000287molecular_functionmagnesium ion binding
A0001725cellular_componentstress fiber
A0003785molecular_functionactin monomer binding
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005523molecular_functiontropomyosin binding
A0005524molecular_functionATP binding
A0005737cellular_componentcytoplasm
A0005856cellular_componentcytoskeleton
A0005865cellular_componentstriated muscle thin filament
A0005884cellular_componentactin filament
A0010628biological_processpositive regulation of gene expression
A0016787molecular_functionhydrolase activity
A0019904molecular_functionprotein domain specific binding
A0030027cellular_componentlamellipodium
A0030041biological_processactin filament polymerization
A0030175cellular_componentfilopodium
A0030240biological_processskeletal muscle thin filament assembly
A0031013molecular_functiontroponin I binding
A0031432molecular_functiontitin binding
A0031941cellular_componentfilamentous actin
A0032036molecular_functionmyosin heavy chain binding
A0032432cellular_componentactin filament bundle
A0042802molecular_functionidentical protein binding
A0044297cellular_componentcell body
A0048306molecular_functioncalcium-dependent protein binding
A0048741biological_processskeletal muscle fiber development
A0051017biological_processactin filament bundle assembly
A0090131biological_processmesenchyme migration
A0098723cellular_componentskeletal muscle myofibril
A0140660molecular_functioncytoskeletal motor activator activity
B0000287molecular_functionmagnesium ion binding
B0001725cellular_componentstress fiber
B0003785molecular_functionactin monomer binding
B0005509molecular_functioncalcium ion binding
B0005515molecular_functionprotein binding
B0005523molecular_functiontropomyosin binding
B0005524molecular_functionATP binding
B0005737cellular_componentcytoplasm
B0005856cellular_componentcytoskeleton
B0005865cellular_componentstriated muscle thin filament
B0005884cellular_componentactin filament
B0010628biological_processpositive regulation of gene expression
B0016787molecular_functionhydrolase activity
B0019904molecular_functionprotein domain specific binding
B0030027cellular_componentlamellipodium
B0030041biological_processactin filament polymerization
B0030175cellular_componentfilopodium
B0030240biological_processskeletal muscle thin filament assembly
B0031013molecular_functiontroponin I binding
B0031432molecular_functiontitin binding
B0031941cellular_componentfilamentous actin
B0032036molecular_functionmyosin heavy chain binding
B0032432cellular_componentactin filament bundle
B0042802molecular_functionidentical protein binding
B0044297cellular_componentcell body
B0048306molecular_functioncalcium-dependent protein binding
B0048741biological_processskeletal muscle fiber development
B0051017biological_processactin filament bundle assembly
B0090131biological_processmesenchyme migration
B0098723cellular_componentskeletal muscle myofibril
B0140660molecular_functioncytoskeletal motor activator activity
C0000287molecular_functionmagnesium ion binding
C0001725cellular_componentstress fiber
C0003785molecular_functionactin monomer binding
C0005509molecular_functioncalcium ion binding
C0005515molecular_functionprotein binding
C0005523molecular_functiontropomyosin binding
C0005524molecular_functionATP binding
C0005737cellular_componentcytoplasm
C0005856cellular_componentcytoskeleton
C0005865cellular_componentstriated muscle thin filament
C0005884cellular_componentactin filament
C0010628biological_processpositive regulation of gene expression
C0016787molecular_functionhydrolase activity
C0019904molecular_functionprotein domain specific binding
C0030027cellular_componentlamellipodium
C0030041biological_processactin filament polymerization
C0030175cellular_componentfilopodium
C0030240biological_processskeletal muscle thin filament assembly
C0031013molecular_functiontroponin I binding
C0031432molecular_functiontitin binding
C0031941cellular_componentfilamentous actin
C0032036molecular_functionmyosin heavy chain binding
C0032432cellular_componentactin filament bundle
C0042802molecular_functionidentical protein binding
C0044297cellular_componentcell body
C0048306molecular_functioncalcium-dependent protein binding
C0048741biological_processskeletal muscle fiber development
C0051017biological_processactin filament bundle assembly
C0090131biological_processmesenchyme migration
C0098723cellular_componentskeletal muscle myofibril
C0140660molecular_functioncytoskeletal motor activator activity
D0000287molecular_functionmagnesium ion binding
D0001725cellular_componentstress fiber
D0003785molecular_functionactin monomer binding
D0005509molecular_functioncalcium ion binding
D0005515molecular_functionprotein binding
D0005523molecular_functiontropomyosin binding
D0005524molecular_functionATP binding
D0005737cellular_componentcytoplasm
D0005856cellular_componentcytoskeleton
D0005865cellular_componentstriated muscle thin filament
D0005884cellular_componentactin filament
D0010628biological_processpositive regulation of gene expression
D0016787molecular_functionhydrolase activity
D0019904molecular_functionprotein domain specific binding
D0030027cellular_componentlamellipodium
D0030041biological_processactin filament polymerization
D0030175cellular_componentfilopodium
D0030240biological_processskeletal muscle thin filament assembly
D0031013molecular_functiontroponin I binding
D0031432molecular_functiontitin binding
D0031941cellular_componentfilamentous actin
D0032036molecular_functionmyosin heavy chain binding
D0032432cellular_componentactin filament bundle
D0042802molecular_functionidentical protein binding
D0044297cellular_componentcell body
D0048306molecular_functioncalcium-dependent protein binding
D0048741biological_processskeletal muscle fiber development
D0051017biological_processactin filament bundle assembly
D0090131biological_processmesenchyme migration
D0098723cellular_componentskeletal muscle myofibril
D0140660molecular_functioncytoskeletal motor activator activity
E0000287molecular_functionmagnesium ion binding
E0001725cellular_componentstress fiber
E0003785molecular_functionactin monomer binding
E0005509molecular_functioncalcium ion binding
E0005515molecular_functionprotein binding
E0005523molecular_functiontropomyosin binding
E0005524molecular_functionATP binding
E0005737cellular_componentcytoplasm
E0005856cellular_componentcytoskeleton
E0005865cellular_componentstriated muscle thin filament
E0005884cellular_componentactin filament
E0010628biological_processpositive regulation of gene expression
E0016787molecular_functionhydrolase activity
E0019904molecular_functionprotein domain specific binding
E0030027cellular_componentlamellipodium
E0030041biological_processactin filament polymerization
E0030175cellular_componentfilopodium
E0030240biological_processskeletal muscle thin filament assembly
E0031013molecular_functiontroponin I binding
E0031432molecular_functiontitin binding
E0031941cellular_componentfilamentous actin
E0032036molecular_functionmyosin heavy chain binding
E0032432cellular_componentactin filament bundle
E0042802molecular_functionidentical protein binding
E0044297cellular_componentcell body
E0048306molecular_functioncalcium-dependent protein binding
E0048741biological_processskeletal muscle fiber development
E0051017biological_processactin filament bundle assembly
E0090131biological_processmesenchyme migration
E0098723cellular_componentskeletal muscle myofibril
E0140660molecular_functioncytoskeletal motor activator activity
F0000287molecular_functionmagnesium ion binding
F0001725cellular_componentstress fiber
F0003785molecular_functionactin monomer binding
F0005509molecular_functioncalcium ion binding
F0005515molecular_functionprotein binding
F0005523molecular_functiontropomyosin binding
F0005524molecular_functionATP binding
F0005737cellular_componentcytoplasm
F0005856cellular_componentcytoskeleton
F0005865cellular_componentstriated muscle thin filament
F0005884cellular_componentactin filament
F0010628biological_processpositive regulation of gene expression
F0016787molecular_functionhydrolase activity
F0019904molecular_functionprotein domain specific binding
F0030027cellular_componentlamellipodium
F0030041biological_processactin filament polymerization
F0030175cellular_componentfilopodium
F0030240biological_processskeletal muscle thin filament assembly
F0031013molecular_functiontroponin I binding
F0031432molecular_functiontitin binding
F0031941cellular_componentfilamentous actin
F0032036molecular_functionmyosin heavy chain binding
F0032432cellular_componentactin filament bundle
F0042802molecular_functionidentical protein binding
F0044297cellular_componentcell body
F0048306molecular_functioncalcium-dependent protein binding
F0048741biological_processskeletal muscle fiber development
F0051017biological_processactin filament bundle assembly
F0090131biological_processmesenchyme migration
F0098723cellular_componentskeletal muscle myofibril
F0140660molecular_functioncytoskeletal motor activator activity
G0000287molecular_functionmagnesium ion binding
G0001725cellular_componentstress fiber
G0003785molecular_functionactin monomer binding
G0005509molecular_functioncalcium ion binding
G0005515molecular_functionprotein binding
G0005523molecular_functiontropomyosin binding
G0005524molecular_functionATP binding
G0005737cellular_componentcytoplasm
G0005856cellular_componentcytoskeleton
G0005865cellular_componentstriated muscle thin filament
G0005884cellular_componentactin filament
G0010628biological_processpositive regulation of gene expression
G0016787molecular_functionhydrolase activity
G0019904molecular_functionprotein domain specific binding
G0030027cellular_componentlamellipodium
G0030041biological_processactin filament polymerization
G0030175cellular_componentfilopodium
G0030240biological_processskeletal muscle thin filament assembly
G0031013molecular_functiontroponin I binding
G0031432molecular_functiontitin binding
G0031941cellular_componentfilamentous actin
G0032036molecular_functionmyosin heavy chain binding
G0032432cellular_componentactin filament bundle
G0042802molecular_functionidentical protein binding
G0044297cellular_componentcell body
G0048306molecular_functioncalcium-dependent protein binding
G0048741biological_processskeletal muscle fiber development
G0051017biological_processactin filament bundle assembly
G0090131biological_processmesenchyme migration
G0098723cellular_componentskeletal muscle myofibril
G0140660molecular_functioncytoskeletal motor activator activity
I0000281biological_processmitotic cytokinesis
I0003779molecular_functionactin binding
I0005515molecular_functionprotein binding
I0005615cellular_componentextracellular space
I0005634cellular_componentnucleus
I0005737cellular_componentcytoplasm
I0005829cellular_componentcytosol
I0005856cellular_componentcytoskeleton
I0005886cellular_componentplasma membrane
I0005925cellular_componentfocal adhesion
I0007010biological_processcytoskeleton organization
I0007266biological_processRho protein signal transduction
I0009615biological_processresponse to virus
I0015629cellular_componentactin cytoskeleton
I0016020cellular_componentmembrane
I0016363cellular_componentnuclear matrix
I0022604biological_processregulation of cell morphogenesis
I0030027cellular_componentlamellipodium
I0030036biological_processactin cytoskeleton organization
I0030042biological_processactin filament depolymerization
I0030043biological_processactin filament fragmentation
I0030424cellular_componentaxon
I0030426cellular_componentgrowth cone
I0031258cellular_componentlamellipodium membrane
I0031982cellular_componentvesicle
I0032587cellular_componentruffle membrane
I0040019biological_processpositive regulation of embryonic development
I0042995cellular_componentcell projection
I0043066biological_processnegative regulation of apoptotic process
I0044794biological_processpositive regulation by host of viral process
I0051014biological_processactin filament severing
I0051015molecular_functionactin filament binding
I0051293biological_processestablishment of spindle localization
I0061001biological_processregulation of dendritic spine morphogenesis
I0070062cellular_componentextracellular exosome
Functional Information from PDB Data
site_idAC1
Number of Residues2
Detailsbinding site for residue MG A 801
ChainResidue
AGLN137
AADP802

site_idAC2
Number of Residues14
Detailsbinding site for residue ADP A 802
ChainResidue
AGLU214
AGLY301
AGLY302
ATHR303
ATYR306
ALYS336
AMG801
AGLY13
ASER14
ALEU16
ALYS18
AGLY156
AASP157
ALYS213

site_idAC3
Number of Residues2
Detailsbinding site for residue MG B 801
ChainResidue
BGLN137
BADP802

site_idAC4
Number of Residues14
Detailsbinding site for residue ADP B 802
ChainResidue
BGLY13
BSER14
BLEU16
BLYS18
BGLY156
BASP157
BLYS213
BGLU214
BGLY301
BGLY302
BTHR303
BTYR306
BLYS336
BMG801

site_idAC5
Number of Residues2
Detailsbinding site for residue MG C 801
ChainResidue
CGLN137
CADP802

site_idAC6
Number of Residues14
Detailsbinding site for residue ADP C 802
ChainResidue
CGLY13
CSER14
CLEU16
CLYS18
CGLY156
CASP157
CLYS213
CGLU214
CGLY301
CGLY302
CTHR303
CTYR306
CLYS336
CMG801

site_idAC7
Number of Residues2
Detailsbinding site for residue MG D 801
ChainResidue
DGLN137
DADP802

site_idAC8
Number of Residues14
Detailsbinding site for residue ADP D 802
ChainResidue
DGLY13
DSER14
DLEU16
DLYS18
DGLY156
DASP157
DLYS213
DGLU214
DGLY301
DGLY302
DTHR303
DTYR306
DLYS336
DMG801

site_idAC9
Number of Residues2
Detailsbinding site for residue MG E 801
ChainResidue
EGLN137
EADP802

site_idAD1
Number of Residues14
Detailsbinding site for residue ADP E 802
ChainResidue
EGLY13
ESER14
ELEU16
ELYS18
EGLY156
EASP157
ELYS213
EGLU214
EGLY301
EGLY302
ETHR303
ETYR306
ELYS336
EMG801

site_idAD2
Number of Residues2
Detailsbinding site for residue MG F 801
ChainResidue
FGLN137
FADP802

site_idAD3
Number of Residues14
Detailsbinding site for residue ADP F 802
ChainResidue
FGLY13
FSER14
FLEU16
FLYS18
FGLY156
FASP157
FLYS213
FGLU214
FGLY301
FGLY302
FTHR303
FTYR306
FLYS336
FMG801

site_idAD4
Number of Residues2
Detailsbinding site for residue MG G 801
ChainResidue
GGLN137
GADP802

site_idAD5
Number of Residues14
Detailsbinding site for residue ADP G 802
ChainResidue
GSER14
GLEU16
GLYS18
GGLY156
GASP157
GLYS213
GGLU214
GGLY301
GGLY302
GTHR303
GTYR306
GLYS336
GMG801
GGLY13

Functional Information from PROSITE/UniProt
site_idPS00406
Number of Residues11
DetailsACTINS_1 Actins signature 1. YVGDEAQs.KRG
ChainResidueDetails
ATYR53-GLY63

site_idPS00432
Number of Residues9
DetailsACTINS_2 Actins signature 2. WITKqEYDE
ChainResidueDetails
ATRP356-GLU364

site_idPS01132
Number of Residues13
DetailsACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEApLNPkaNR
ChainResidueDetails
ALEU104-ARG116

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: N-acetylalanine => ECO:0000269|PubMed:30550596, ECO:0000269|Ref.9, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378, ECO:0007744|PubMed:25944712
ChainResidueDetails
IALA2
BCYS0
CCYS0
DCYS0
ECYS0
FCYS0
GCYS0

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphoserine; by NRK => ECO:0000269|PubMed:12837278, ECO:0000269|PubMed:30550596, ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
ChainResidueDetails
IASP3
BASP1
CASP1
DASP1
EASP1
FASP1
GASP1

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P18760
ChainResidueDetails
AMET47
BMET44
BMET47
ISER8
CMET44
CMET47
DMET44
DMET47
EMET44
EMET47
FMET44
FMET47
GMET44
GMET47

site_idSWS_FT_FI4
Number of Residues3
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
ILYS13
ILYS73
ILYS144
DLYS61
ELYS61
FLYS61
GLYS61

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:20068231
ChainResidueDetails
BHIS73
ITHR25
CHIS73
DHIS73
EHIS73
FHIS73
GHIS73

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ISER41
BLYS84
CLYS84
DLYS84
ELYS84
FLYS84
GLYS84

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0000269|PubMed:30550596
ChainResidueDetails
ITHR63
BARG177
CARG177
DARG177
EARG177
FARG177
GARG177

site_idSWS_FT_FI8
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:19690332
ChainResidueDetails
ITYR68

site_idSWS_FT_FI9
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0000269|PubMed:30550596
ChainResidueDetails
ITYR82

site_idSWS_FT_FI10
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:30550596
ChainResidueDetails
ISER108

site_idSWS_FT_FI11
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:15592455
ChainResidueDetails
ITYR140

site_idSWS_FT_FI12
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:30550596, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
ISER156

site_idSWS_FT_FI13
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
ILYS132

219869

PDB entries from 2024-05-15

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