6TT2
The PH domain of Bruton's tyrosine kinase mutant R28C
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 201 |
| Chain | Residue |
| A | HOH313 |
| A | HOH359 |
| B | GLU96 |
| B | HOH364 |
| B | HOH412 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 202 |
| Chain | Residue |
| A | HIS143 |
| A | CYS154 |
| A | CYS155 |
| A | CYS165 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue MG B 201 |
| Chain | Residue |
| A | GLU96 |
| B | HOH304 |
| B | HOH307 |
| B | HOH338 |
| B | HOH411 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 202 |
| Chain | Residue |
| B | HIS143 |
| B | CYS154 |
| B | CYS155 |
| B | CYS165 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10196129 |
| Chain | Residue | Details |
| B | LYS26 | |
| B | CYS28 | |
| B | TYR39 | |
| B | LYS53 | |
| A | LYS26 | |
| A | CYS28 | |
| A | TYR39 | |
| A | LYS53 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00432, ECO:0000269|PubMed:10196129, ECO:0000269|PubMed:9218782, ECO:0000269|Ref.48 |
| Chain | Residue | Details |
| B | CYS155 | |
| B | CYS165 | |
| A | CYS165 | |
| B | HIS143 | |
| B | CYS154 | |
| A | HIS143 | |
| A | CYS154 | |
| A | CYS155 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: N-acetylalanine => ECO:0000269|Ref.11, ECO:0007744|PubMed:25944712 |
| Chain | Residue | Details |
| B | ALA2 | |
| A | ALA2 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:16644721 |
| Chain | Residue | Details |
| B | SER21 | |
| B | SER115 | |
| A | SER115 | |
| A | SER21 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P35991 |
| Chain | Residue | Details |
| A | TYR40 | |
| B | TYR40 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19369195 |
| Chain | Residue | Details |
| B | SER55 | |
| A | SER55 |
