6TLL
HUMAN CK2 KINASE ALPHA SUBUNIT IN COMPLEX WITH THE ATP-COMPETITIVE INHIBITOR 4,5,6,7-TETRABROMOBENZOTRIAZOLE (tBBT)
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004672 | molecular_function | protein kinase activity |
A | 0004674 | molecular_function | protein serine/threonine kinase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005524 | molecular_function | ATP binding |
A | 0005634 | cellular_component | nucleus |
A | 0005654 | cellular_component | nucleoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0005886 | cellular_component | plasma membrane |
A | 0005956 | cellular_component | protein kinase CK2 complex |
A | 0006302 | biological_process | double-strand break repair |
A | 0006468 | biological_process | protein phosphorylation |
A | 0006915 | biological_process | apoptotic process |
A | 0006974 | biological_process | DNA damage response |
A | 0007165 | biological_process | signal transduction |
A | 0008284 | biological_process | positive regulation of cell population proliferation |
A | 0016055 | biological_process | Wnt signaling pathway |
A | 0016301 | molecular_function | kinase activity |
A | 0016605 | cellular_component | PML body |
A | 0017148 | biological_process | negative regulation of translation |
A | 0018105 | biological_process | peptidyl-serine phosphorylation |
A | 0018107 | biological_process | peptidyl-threonine phosphorylation |
A | 0030177 | biological_process | positive regulation of Wnt signaling pathway |
A | 0030307 | biological_process | positive regulation of cell growth |
A | 0031519 | cellular_component | PcG protein complex |
A | 0032435 | biological_process | negative regulation of proteasomal ubiquitin-dependent protein catabolic process |
A | 0042802 | molecular_function | identical protein binding |
A | 0043154 | biological_process | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process |
A | 0045732 | biological_process | positive regulation of protein catabolic process |
A | 0048511 | biological_process | rhythmic process |
A | 0050821 | biological_process | protein stabilization |
A | 0051726 | biological_process | regulation of cell cycle |
A | 0051879 | molecular_function | Hsp90 protein binding |
A | 0061077 | biological_process | chaperone-mediated protein folding |
A | 0070822 | cellular_component | Sin3-type complex |
A | 0075342 | biological_process | symbiont-mediated disruption of host cell PML body |
A | 0106310 | molecular_function | protein serine kinase activity |
A | 1905337 | biological_process | positive regulation of aggrephagy |
A | 1905818 | biological_process | regulation of chromosome separation |
A | 2000042 | biological_process | negative regulation of double-strand break repair via homologous recombination |
A | 2001234 | biological_process | negative regulation of apoptotic signaling pathway |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 16 |
Details | binding site for residue TBS A 401 |
Chain | Residue |
A | VAL53 |
A | HIS160 |
A | MET163 |
A | ILE174 |
A | ASP175 |
A | HOH702 |
A | HOH786 |
A | HOH851 |
A | VAL66 |
A | LYS68 |
A | ILE95 |
A | PHE113 |
A | GLU114 |
A | VAL116 |
A | ASN117 |
A | ASN118 |
site_id | AC2 |
Number of Residues | 15 |
Details | binding site for residue TBS A 402 |
Chain | Residue |
A | ARG21 |
A | GLN36 |
A | TYR39 |
A | LEU41 |
A | ILE69 |
A | VAL101 |
A | ASP103 |
A | SER106 |
A | THR108 |
A | ALA110 |
A | HOH518 |
A | HOH571 |
A | HOH611 |
A | HOH818 |
A | HOH846 |
site_id | AC3 |
Number of Residues | 8 |
Details | binding site for residue PEG A 403 |
Chain | Residue |
A | ARG89 |
A | GLY90 |
A | TYR146 |
A | HOH508 |
A | HOH614 |
A | HOH640 |
A | HOH715 |
A | HOH934 |
site_id | AC4 |
Number of Residues | 5 |
Details | binding site for residue PEG A 404 |
Chain | Residue |
A | ARG10 |
A | GLU282 |
A | GLN310 |
A | SER311 |
A | HOH687 |
site_id | AC5 |
Number of Residues | 6 |
Details | binding site for residue NA A 405 |
Chain | Residue |
A | GLN290 |
A | VAL293 |
A | HOH538 |
A | HOH721 |
A | HOH727 |
A | HOH862 |
site_id | AC6 |
Number of Residues | 2 |
Details | binding site for residue CL A 406 |
Chain | Residue |
A | PRO159 |
A | HIS160 |
site_id | AC7 |
Number of Residues | 4 |
Details | binding site for residue CL A 407 |
Chain | Residue |
A | ARG280 |
A | HOH719 |
A | HOH773 |
A | HOH788 |
Functional Information from PROSITE/UniProt
site_id | PS00107 |
Number of Residues | 24 |
Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGRGKYSEVFeAinitnnek..........VVVK |
Chain | Residue | Details |
A | LEU45-LYS68 |
site_id | PS00108 |
Number of Residues | 13 |
Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ImHrDVKphNVMI |
Chain | Residue | Details |
A | ILE152-ILE164 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | ACT_SITE: Proton acceptor |
Chain | Residue | Details |
A | ASP156 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 |
Chain | Residue | Details |
A | LYS68 | |
A | LEU45 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | MOD_RES: Phosphothreonine; by CDK1 => ECO:0000269|PubMed:7592773 |
Chain | Residue | Details |
A | THR360 | |
A | THR344 |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine; by CDK1 => ECO:0000269|PubMed:7592773 |
Chain | Residue | Details |
A | SER362 |
site_id | SWS_FT_FI5 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine; by CDK1 => ECO:0000269|PubMed:7592773, ECO:0007744|PubMed:18691976 |
Chain | Residue | Details |
A | SER370 |