6TD3

Structure of DDB1 bound to CR8-engaged CDK12-cyclinK

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0005634	cellular_component	nucleus
B	0004672	molecular_function	protein kinase activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation
C	0006357	biological_process	regulation of transcription by RNA polymerase II
C	0016538	molecular_function	cyclin-dependent protein serine/threonine kinase regulator activity
D	0003676	molecular_function	nucleic acid binding
D	0005634	cellular_component	nucleus
E	0004672	molecular_function	protein kinase activity
E	0005524	molecular_function	ATP binding
E	0006468	biological_process	protein phosphorylation
F	0006357	biological_process	regulation of transcription by RNA polymerase II
F	0016538	molecular_function	cyclin-dependent protein serine/threonine kinase regulator activity
G	0003676	molecular_function	nucleic acid binding
G	0005634	cellular_component	nucleus
H	0004672	molecular_function	protein kinase activity
H	0005524	molecular_function	ATP binding
H	0006468	biological_process	protein phosphorylation
I	0006357	biological_process	regulation of transcription by RNA polymerase II
I	0016538	molecular_function	cyclin-dependent protein serine/threonine kinase regulator activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue RC8 B 1101

Chain	Residue
A	ASN907
B	ASP817
B	HIS818
B	ASP819
B	LEU866
A	ARG928
A	ARG947
B	ILE733
B	ALA754
B	PHE813
B	GLU814
B	TYR815
B	MET816

---

site_id	AC2
Number of Residues	13
Details	binding site for residue RC8 E 1101

Chain	Residue
D	ASN907
D	ARG928
D	ARG947
E	ILE733
E	ALA754
E	PHE813
E	GLU814
E	TYR815
E	MET816
E	ASP817
E	HIS818
E	ASP819
E	LEU866

---

site_id	AC3
Number of Residues	14
Details	binding site for residue RC8 H 1101

Chain	Residue
G	ASN907
G	ARG928
G	ARG947
H	ILE733
H	ALA754
H	PHE813
H	GLU814
H	TYR815
H	MET816
H	ASP817
H	HIS818
H	ASP819
H	LEU866
H	ASP877

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGEGTYGQVYkAkdkdtgel..........VALK

Chain	Residue	Details
B	ILE733-LYS756

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. FlHrDIKcsNILL

Chain	Residue	Details
B	PHE855-LEU867

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027

Chain	Residue	Details
B	ASP859
E	ASP859
H	ASP859

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	BINDING:

Chain	Residue	Details
B	HIS1040
E	ILE733
E	LYS756
E	GLU814
E	HIS1040
H	ILE733
H	LYS756
H	GLU814
H	HIS1040
B	LYS756
B	GLU814
B	ILE733

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
H	SER889
B	SER889
E	SER889

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	MOD_RES: Phosphothreonine => ECO:0000269|PubMed:24662513, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
G	LYS1121
H	TPO893
E	TPO893
B	TPO893

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