6T0G
Crystal structure of CYP124 in complex with vitamin D3
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004497 | molecular_function | monooxygenase activity |
A | 0005506 | molecular_function | iron ion binding |
A | 0006631 | biological_process | fatty acid metabolic process |
A | 0006707 | biological_process | cholesterol catabolic process |
A | 0008395 | molecular_function | steroid hydroxylase activity |
A | 0010430 | biological_process | fatty acid omega-oxidation |
A | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
A | 0020037 | molecular_function | heme binding |
A | 0031073 | molecular_function | cholesterol 26-hydroxylase activity |
A | 0036199 | molecular_function | cholest-4-en-3-one 26-monooxygenase activity |
A | 0046872 | molecular_function | metal ion binding |
A | 0070402 | molecular_function | NADPH binding |
A | 0097089 | biological_process | methyl-branched fatty acid metabolic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 22 |
Details | binding site for residue HEM A 501 |
Chain | Residue |
A | ILE111 |
A | ARG320 |
A | TYR343 |
A | GLY370 |
A | PHE371 |
A | GLY372 |
A | HIS377 |
A | CYS379 |
A | GLY381 |
A | VD3502 |
A | HOH685 |
A | HIS118 |
A | HOH740 |
A | HOH742 |
A | HOH807 |
A | ARG122 |
A | LEU264 |
A | ALA267 |
A | GLY268 |
A | THR271 |
A | THR272 |
A | VAL315 |
site_id | AC2 |
Number of Residues | 4 |
Details | binding site for residue VD3 A 502 |
Chain | Residue |
A | ASN93 |
A | THR95 |
A | ILE197 |
A | HEM501 |
site_id | AC3 |
Number of Residues | 6 |
Details | binding site for residue MG A 503 |
Chain | Residue |
A | HOH752 |
A | HOH816 |
A | HOH1071 |
A | HOH1110 |
A | HOH1288 |
A | HOH1314 |
site_id | AC4 |
Number of Residues | 6 |
Details | binding site for residue MG A 504 |
Chain | Residue |
A | HOH663 |
A | HOH728 |
A | HOH1093 |
A | HOH1113 |
A | HOH1229 |
A | HOH1324 |
site_id | AC5 |
Number of Residues | 5 |
Details | binding site for residue PGE A 505 |
Chain | Residue |
A | HIS84 |
A | PRO85 |
A | ASP86 |
A | ILE87 |
A | PGE506 |
site_id | AC6 |
Number of Residues | 3 |
Details | binding site for residue PGE A 506 |
Chain | Residue |
A | HIS84 |
A | ILE87 |
A | PGE505 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | BINDING: axial binding residue => ECO:0000269|PubMed:19933331, ECO:0007744|PDB:2WM4, ECO:0007744|PDB:2WM5 |
Chain | Residue | Details |
A | CYS379 |