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6SZ5

Human calmodulin bound to a peptide of human NADPH oxidase 5

Functional Information from GO Data
ChainGOidnamespacecontents
A0000086biological_processG2/M transition of mitotic cell cycle
A0000922cellular_componentspindle pole
A0002027biological_processregulation of heart rate
A0005509molecular_functioncalcium ion binding
A0005513biological_processdetection of calcium ion
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005813cellular_componentcentrosome
A0005819cellular_componentspindle
A0005856cellular_componentcytoskeleton
A0005876cellular_componentspindle microtubule
A0005886cellular_componentplasma membrane
A0007186biological_processG protein-coupled receptor signaling pathway
A0008076cellular_componentvoltage-gated potassium channel complex
A0008179molecular_functionadenylate cyclase binding
A0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
A0010801biological_processnegative regulation of peptidyl-threonine phosphorylation
A0010856molecular_functionadenylate cyclase activator activity
A0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
A0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
A0016020cellular_componentmembrane
A0019855molecular_functioncalcium channel inhibitor activity
A0019901molecular_functionprotein kinase binding
A0021762biological_processsubstantia nigra development
A0030017cellular_componentsarcomere
A0031432molecular_functiontitin binding
A0031954biological_processpositive regulation of protein autophosphorylation
A0031982cellular_componentvesicle
A0032465biological_processregulation of cytokinesis
A0032516biological_processpositive regulation of phosphoprotein phosphatase activity
A0032991cellular_componentprotein-containing complex
A0034704cellular_componentcalcium channel complex
A0035307biological_processpositive regulation of protein dephosphorylation
A0043209cellular_componentmyelin sheath
A0043539molecular_functionprotein serine/threonine kinase activator activity
A0044325molecular_functiontransmembrane transporter binding
A0046872molecular_functionmetal ion binding
A0048306molecular_functioncalcium-dependent protein binding
A0050848biological_processregulation of calcium-mediated signaling
A0051343biological_processpositive regulation of cyclic-nucleotide phosphodiesterase activity
A0051592biological_processresponse to calcium ion
A0055117biological_processregulation of cardiac muscle contraction
A0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
A0060316biological_processpositive regulation of ryanodine-sensitive calcium-release channel activity
A0071902biological_processpositive regulation of protein serine/threonine kinase activity
A0072542molecular_functionprotein phosphatase activator activity
A0097225cellular_componentsperm midpiece
A1901020biological_processnegative regulation of calcium ion transmembrane transporter activity
A1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
A1902494cellular_componentcatalytic complex
A1905913biological_processnegative regulation of calcium ion export across plasma membrane
B0001525biological_processangiogenesis
B0001819biological_processpositive regulation of cytokine production
B0001935biological_processendothelial cell proliferation
B0005509molecular_functioncalcium ion binding
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0005886cellular_componentplasma membrane
B0006915biological_processapoptotic process
B0006952biological_processdefense response
B0015252molecular_functionproton channel activity
B0016175molecular_functionsuperoxide-generating NAD(P)H oxidase activity
B0016491molecular_functionoxidoreductase activity
B0020037molecular_functionheme binding
B0034220biological_processmonoatomic ion transmembrane transport
B0042554biological_processsuperoxide anion generation
B0043012biological_processregulation of fusion of sperm to egg plasma membrane
B0043020cellular_componentNADPH oxidase complex
B0046872molecular_functionmetal ion binding
B0050660molecular_functionflavin adenine dinucleotide binding
B0050661molecular_functionNADP binding
B0050664molecular_functionoxidoreductase activity, acting on NAD(P)H, oxygen as acceptor
B0061640biological_processcytoskeleton-dependent cytokinesis
B0106292molecular_functionsuperoxide-generating NADPH oxidase activity
B1902600biological_processproton transmembrane transport
C0001525biological_processangiogenesis
C0001819biological_processpositive regulation of cytokine production
C0001935biological_processendothelial cell proliferation
C0005509molecular_functioncalcium ion binding
C0005783cellular_componentendoplasmic reticulum
C0005789cellular_componentendoplasmic reticulum membrane
C0005886cellular_componentplasma membrane
C0006915biological_processapoptotic process
C0006952biological_processdefense response
C0015252molecular_functionproton channel activity
C0016175molecular_functionsuperoxide-generating NAD(P)H oxidase activity
C0016491molecular_functionoxidoreductase activity
C0020037molecular_functionheme binding
C0034220biological_processmonoatomic ion transmembrane transport
C0042554biological_processsuperoxide anion generation
C0043012biological_processregulation of fusion of sperm to egg plasma membrane
C0043020cellular_componentNADPH oxidase complex
C0046872molecular_functionmetal ion binding
C0050660molecular_functionflavin adenine dinucleotide binding
C0050661molecular_functionNADP binding
C0050664molecular_functionoxidoreductase activity, acting on NAD(P)H, oxygen as acceptor
C0061640biological_processcytoskeleton-dependent cytokinesis
C0106292molecular_functionsuperoxide-generating NADPH oxidase activity
C1902600biological_processproton transmembrane transport
Functional Information from PDB Data
site_idAC1
Number of Residues5
Detailsbinding site for residue CA A 501
ChainResidue
AASP130
AASP132
AASP134
AGLN136
AGLU141

site_idAC2
Number of Residues5
Detailsbinding site for residue CA A 502
ChainResidue
AGLU105
AASP94
AASP96
AASN98
ATYR100

site_idAC3
Number of Residues5
Detailsbinding site for residue CA A 503
ChainResidue
AASP57
AASP59
AASN61
ATHR63
AGLU68

site_idAC4
Number of Residues6
Detailsbinding site for residue CA A 504
ChainResidue
AASP21
AASP23
AASP25
ATHR27
AGLU32
AASP119

Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DKDGDGTITtkEL
ChainResidueDetails
AASP21-LEU33
AASP57-PHE69
AASP94-LEU106
AASP130-PHE142
BASP25-LEU37
BASP61-LEU73
BASP105-LEU117

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues288
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
BVAL194-LEU214
BTRP222-MET244
BPRO273-SER293
BARG318-LEU338
BLEU350-ALA372
BILE390-THR410
BHIS539-HIS559
CVAL194-LEU214
CTRP222-MET244
CPRO273-SER293
CARG318-LEU338
CLEU350-ALA372
CILE390-THR410
CHIS539-HIS559
AGLU105
AASP130
AASP132
AASP134
AGLN136
AGLU141

site_idSWS_FT_FI2
Number of Residues90
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
BMET215-THR221
BALA294-ARG317
BVAL373-LEU389
CMET215-THR221
CALA294-ARG317
CVAL373-LEU389

site_idSWS_FT_FI3
Number of Residues328
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
BGLY245-SER272
BLEU339-TRP349
BILE411-LYS538
CGLY245-SER272
CLEU339-TRP349
CILE411-LYS538

site_idSWS_FT_FI4
Number of Residues16
DetailsBINDING: BINDING => ECO:0000305
ChainResidueDetails
BASP-3
BGLU4
BGLU-1
BGLN95
BLEU100
CASP-3
CGLU-1
CGLU4
CASP61
CASP63
CLEU93
CGLN95
CLEU100
BASP61
BASP63
BLEU93

site_idSWS_FT_FI5
Number of Residues18
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448
ChainResidueDetails
BSER29
BTHR31
BGLU36
BASP25
BASP27
CASP27
CSER29
CTHR31
CGLU36
CILE133
CALA135
CHIS137
CPRO144
BILE133
BALA135
BHIS137
BPRO144
CASP25

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS95

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332
ChainResidueDetails
ATYR100

site_idSWS_FT_FI8
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
ASER102

site_idSWS_FT_FI9
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569
ChainResidueDetails
ATHR111

site_idSWS_FT_FI10
Number of Residues1
DetailsMOD_RES: N6-methyllysine; alternate => ECO:0007744|PubMed:24129315
ChainResidueDetails
ALYS116

site_idSWS_FT_FI11
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:19690332
ChainResidueDetails
ATYR139

site_idSWS_FT_FI12
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P62157
ChainResidueDetails
ALYS22

221051

PDB entries from 2024-06-12

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