Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6SU1

Trypanosoma congolense pyruvate kinase in complex with citrate and glycerol

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0003824	molecular_function	catalytic activity
A	0004743	molecular_function	pyruvate kinase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0006096	biological_process	glycolytic process
A	0016301	molecular_function	kinase activity
A	0030955	molecular_function	potassium ion binding
A	0032869	biological_process	cellular response to insulin stimulus
A	0046872	molecular_function	metal ion binding
B	0000287	molecular_function	magnesium ion binding
B	0003824	molecular_function	catalytic activity
B	0004743	molecular_function	pyruvate kinase activity
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0006096	biological_process	glycolytic process
B	0016301	molecular_function	kinase activity
B	0030955	molecular_function	potassium ion binding
B	0032869	biological_process	cellular response to insulin stimulus
B	0046872	molecular_function	metal ion binding
C	0000287	molecular_function	magnesium ion binding
C	0003824	molecular_function	catalytic activity
C	0004743	molecular_function	pyruvate kinase activity
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0006096	biological_process	glycolytic process
C	0016301	molecular_function	kinase activity
C	0030955	molecular_function	potassium ion binding
C	0032869	biological_process	cellular response to insulin stimulus
C	0046872	molecular_function	metal ion binding
D	0000287	molecular_function	magnesium ion binding
D	0003824	molecular_function	catalytic activity
D	0004743	molecular_function	pyruvate kinase activity
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0006096	biological_process	glycolytic process
D	0016301	molecular_function	kinase activity
D	0030955	molecular_function	potassium ion binding
D	0032869	biological_process	cellular response to insulin stimulus
D	0046872	molecular_function	metal ion binding
E	0000287	molecular_function	magnesium ion binding
E	0003824	molecular_function	catalytic activity
E	0004743	molecular_function	pyruvate kinase activity
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0006096	biological_process	glycolytic process
E	0016301	molecular_function	kinase activity
E	0030955	molecular_function	potassium ion binding
E	0032869	biological_process	cellular response to insulin stimulus
E	0046872	molecular_function	metal ion binding
F	0000287	molecular_function	magnesium ion binding
F	0003824	molecular_function	catalytic activity
F	0004743	molecular_function	pyruvate kinase activity
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0006096	biological_process	glycolytic process
F	0016301	molecular_function	kinase activity
F	0030955	molecular_function	potassium ion binding
F	0032869	biological_process	cellular response to insulin stimulus
F	0046872	molecular_function	metal ion binding
G	0000287	molecular_function	magnesium ion binding
G	0003824	molecular_function	catalytic activity
G	0004743	molecular_function	pyruvate kinase activity
G	0005524	molecular_function	ATP binding
G	0005737	cellular_component	cytoplasm
G	0006096	biological_process	glycolytic process
G	0016301	molecular_function	kinase activity
G	0030955	molecular_function	potassium ion binding
G	0032869	biological_process	cellular response to insulin stimulus
G	0046872	molecular_function	metal ion binding
H	0000287	molecular_function	magnesium ion binding
H	0003824	molecular_function	catalytic activity
H	0004743	molecular_function	pyruvate kinase activity
H	0005524	molecular_function	ATP binding
H	0005737	cellular_component	cytoplasm
H	0006096	biological_process	glycolytic process
H	0016301	molecular_function	kinase activity
H	0030955	molecular_function	potassium ion binding
H	0032869	biological_process	cellular response to insulin stimulus
H	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue GOL A 601

Chain	Residue
A	ARG425
A	LEU426
A	LEU427

site_id	AC2
Number of Residues	7
Details	binding site for residue GOL A 602

Chain	Residue
A	TYR489
A	SER401
A	ASN402
A	THR403
A	GLY404
A	ARG405
A	SER406

site_id	AC3
Number of Residues	12
Details	binding site for residue CIT B 601

Chain	Residue
B	ARG50
B	ASN52
B	SER54
B	ASP84
B	LYS239
B	GLU241
B	ALA262
B	ARG263
B	GLY264
B	ASP265
B	THR297
B	SER331

site_id	AC4
Number of Residues	6
Details	binding site for residue GOL B 602

Chain	Residue
B	GLU378
B	SER401
B	THR403
B	ARG405
B	SER406
B	GLY488

site_id	AC5
Number of Residues	4
Details	binding site for residue CIT C 601

Chain	Residue
C	ARG50
C	ASN52
C	LYS239
C	SER331

site_id	AC6
Number of Residues	4
Details	binding site for residue GOL C 602

Chain	Residue
C	HIS481
C	GLN492
C	ARG494
C	HOH705

site_id	AC7
Number of Residues	6
Details	binding site for residue GOL C 603

Chain	Residue
C	GLU378
C	SER401
C	ASN402
C	THR403
C	ARG405
C	SER406

site_id	AC8
Number of Residues	9
Details	binding site for residue CIT D 601

Chain	Residue
D	ARG50
D	ASN52
D	SER54
D	HIS55
D	ASP84
D	GLU89
D	LYS239
D	GLU241
D	ASP265

site_id	AC9
Number of Residues	6
Details	binding site for residue GOL D 602

Chain	Residue
D	LEU400
D	SER401
D	ASN402
D	THR403
D	SER406
D	GLY488

site_id	AD1
Number of Residues	12
Details	binding site for residue CIT E 601

Chain	Residue
E	ARG50
E	ASN52
E	SER54
E	LYS239
E	GLU241
E	MET260
E	ALA262
E	ARG263
E	GLY264
E	ASP265
E	THR297
E	HOH703

site_id	AD2
Number of Residues	5
Details	binding site for residue GOL E 602

Chain	Residue
E	SER401
E	ASN402
E	THR403
E	ARG405
E	SER406

site_id	AD3
Number of Residues	10
Details	binding site for residue CIT F 601

Chain	Residue
F	ARG50
F	ASN52
F	SER54
F	GLU89
F	ALA262
F	ARG263
F	GLY264
F	ASP265
F	THR297
F	SER331

site_id	AD4
Number of Residues	4
Details	binding site for residue GOL F 602

Chain	Residue
F	LEU400
F	SER401
F	ASN402
F	ARG405

site_id	AD5
Number of Residues	1
Details	binding site for residue PGE F 603

Chain	Residue
F	ASP97

site_id	AD6
Number of Residues	8
Details	binding site for residue GOL G 601

Chain	Residue
G	GLU378
G	SER401
G	ASN402
G	THR403
G	SER406
G	GLY488
G	TYR489
G	PRO490

site_id	AD7
Number of Residues	8
Details	binding site for residue CIT H 601

Chain	Residue
H	ARG91
H	LYS239
H	GLU241
H	ALA262
H	ASP265
H	THR297
H	ARG50
H	ASN52

site_id	AD8
Number of Residues	6
Details	binding site for residue GOL H 602

Chain	Residue
H	SER401
H	ASN402
H	THR403
H	ARG405
H	SER406
H	TYR489

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)