6RPR
LEM domain of Emerin mutant T43I in complex with BAF dimer and the Igfold of the lamin A/C
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| D | 0000785 | cellular_component | chromatin |
| D | 0000793 | cellular_component | condensed chromosome |
| D | 0003677 | molecular_function | DNA binding |
| D | 0003690 | molecular_function | double-stranded DNA binding |
| D | 0005515 | molecular_function | protein binding |
| D | 0005634 | cellular_component | nucleus |
| D | 0005635 | cellular_component | nuclear envelope |
| D | 0005654 | cellular_component | nucleoplasm |
| D | 0005694 | cellular_component | chromosome |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006325 | biological_process | chromatin organization |
| D | 0006979 | biological_process | response to oxidative stress |
| D | 0007084 | biological_process | mitotic nuclear membrane reassembly |
| D | 0009615 | biological_process | response to virus |
| D | 0010836 | biological_process | negative regulation of protein ADP-ribosylation |
| D | 0015074 | biological_process | DNA integration |
| D | 0032480 | biological_process | negative regulation of type I interferon production |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0042803 | molecular_function | protein homodimerization activity |
| D | 0045071 | biological_process | negative regulation of viral genome replication |
| D | 0045824 | biological_process | negative regulation of innate immune response |
| D | 0051276 | biological_process | chromosome organization |
| D | 0160049 | biological_process | negative regulation of cGAS/STING signaling pathway |
| E | 0000785 | cellular_component | chromatin |
| E | 0000793 | cellular_component | condensed chromosome |
| E | 0003677 | molecular_function | DNA binding |
| E | 0003690 | molecular_function | double-stranded DNA binding |
| E | 0005515 | molecular_function | protein binding |
| E | 0005634 | cellular_component | nucleus |
| E | 0005635 | cellular_component | nuclear envelope |
| E | 0005654 | cellular_component | nucleoplasm |
| E | 0005694 | cellular_component | chromosome |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0005829 | cellular_component | cytosol |
| E | 0006325 | biological_process | chromatin organization |
| E | 0006979 | biological_process | response to oxidative stress |
| E | 0007084 | biological_process | mitotic nuclear membrane reassembly |
| E | 0009615 | biological_process | response to virus |
| E | 0010836 | biological_process | negative regulation of protein ADP-ribosylation |
| E | 0015074 | biological_process | DNA integration |
| E | 0032480 | biological_process | negative regulation of type I interferon production |
| E | 0042802 | molecular_function | identical protein binding |
| E | 0042803 | molecular_function | protein homodimerization activity |
| E | 0045071 | biological_process | negative regulation of viral genome replication |
| E | 0045824 | biological_process | negative regulation of innate immune response |
| E | 0051276 | biological_process | chromosome organization |
| E | 0160049 | biological_process | negative regulation of cGAS/STING signaling pathway |
| G | 0005635 | cellular_component | nuclear envelope |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 D 101 |
| Chain | Residue |
| D | GLY27 |
| D | GLU28 |
| D | VAL29 |
| D | LEU30 |
| D | GLN73 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 D 102 |
| Chain | Residue |
| D | ARG60 |
| D | ARG75 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 D 103 |
| Chain | Residue |
| D | GLU28 |
| D | HOH212 |
| E | ARG60 |
| E | ARG75 |
| D | LYS6 |
| D | GLY27 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| G | SER8 | |
| E | THR3 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| G | SER29 | |
| E | SER4 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:24741066, ECO:0000269|PubMed:25127216, ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| B | ALA502 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by CDK1 => ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:24741066, ECO:0000269|PubMed:25127216, ECO:0000269|PubMed:37788673, ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| B | ALA504 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by ATR => ECO:0000269|PubMed:37788673, ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| B | SER507 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| B | THR510 | |
| B | ARG541 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:24741066, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| B | LYS515 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:24741066, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| B | ALA516 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:24741066 |
| Chain | Residue | Details |
| B | THR519 | |
| B | GLY535 | |
| B | VAL538 | |
| B | ASN518 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| B | LEU526 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0000269|PubMed:24741066 |
| Chain | Residue | Details |
| B | THR528 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231 |
| Chain | Residue | Details |
| B | LEU543 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| B | LEU478 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 3 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25218447, ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:25772364, ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| B | LYS490 | |
| B | ASN532 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 1 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25218447, ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| B | ALA529 |
