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6RO4

Structure of the core TFIIH-XPA-DNA complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000112cellular_componentnucleotide-excision repair factor 3 complex
A0000439cellular_componenttranscription factor TFIIH core complex
A0000717biological_processnucleotide-excision repair, DNA duplex unwinding
A0001666biological_processresponse to hypoxia
A0003677molecular_functionDNA binding
A0003678molecular_functionDNA helicase activity
A0003684molecular_functiondamaged DNA binding
A0004386molecular_functionhelicase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005669cellular_componenttranscription factor TFIID complex
A0005675cellular_componenttranscription factor TFIIH holo complex
A0006265biological_processDNA topological change
A0006281biological_processDNA repair
A0006283biological_processtranscription-coupled nucleotide-excision repair
A0006289biological_processnucleotide-excision repair
A0006366biological_processtranscription by RNA polymerase II
A0006367biological_processtranscription initiation at RNA polymerase II promoter
A0006368biological_processtranscription elongation by RNA polymerase II
A0006915biological_processapoptotic process
A0006979biological_processresponse to oxidative stress
A0008104biological_processprotein localization
A0009411biological_processresponse to UV
A0009650biological_processUV protection
A0016787molecular_functionhydrolase activity
A0016853molecular_functionisomerase activity
A0016887molecular_functionATP hydrolysis activity
A0035315biological_processhair cell differentiation
A0043065biological_processpositive regulation of apoptotic process
A0043138molecular_function3'-5' DNA helicase activity
A0048568biological_processembryonic organ development
A0097550cellular_componenttranscription preinitiation complex
A0140640molecular_functioncatalytic activity, acting on a nucleic acid
A1901990biological_processregulation of mitotic cell cycle phase transition
A1990841molecular_functionpromoter-specific chromatin binding
B0000439cellular_componenttranscription factor TFIIH core complex
B0000462biological_processmaturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B0001666biological_processresponse to hypoxia
B0001701biological_processin utero embryonic development
B0003676molecular_functionnucleic acid binding
B0003677molecular_functionDNA binding
B0003678molecular_functionDNA helicase activity
B0003684molecular_functiondamaged DNA binding
B0004386molecular_functionhelicase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005669cellular_componenttranscription factor TFIID complex
B0005675cellular_componenttranscription factor TFIIH holo complex
B0005737cellular_componentcytoplasm
B0005819cellular_componentspindle
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0006139biological_processnucleobase-containing compound metabolic process
B0006259biological_processDNA metabolic process
B0006281biological_processDNA repair
B0006283biological_processtranscription-coupled nucleotide-excision repair
B0006289biological_processnucleotide-excision repair
B0006357biological_processregulation of transcription by RNA polymerase II
B0006362biological_processtranscription elongation by RNA polymerase I
B0006366biological_processtranscription by RNA polymerase II
B0006367biological_processtranscription initiation at RNA polymerase II promoter
B0006915biological_processapoptotic process
B0006974biological_processDNA damage response
B0006979biological_processresponse to oxidative stress
B0007059biological_processchromosome segregation
B0008340biological_processdetermination of adult lifespan
B0009411biological_processresponse to UV
B0009650biological_processUV protection
B0009791biological_processpost-embryonic development
B0016787molecular_functionhydrolase activity
B0016818molecular_functionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
B0016887molecular_functionATP hydrolysis activity
B0021510biological_processspinal cord development
B0022405biological_processhair cycle process
B0030198biological_processextracellular matrix organization
B0030282biological_processbone mineralization
B0030674molecular_functionprotein-macromolecule adaptor activity
B0032289biological_processcentral nervous system myelin formation
B0032508biological_processDNA duplex unwinding
B0035264biological_processmulticellular organism growth
B0035315biological_processhair cell differentiation
B0040016biological_processembryonic cleavage
B0042274biological_processribosomal small subunit biogenesis
B0043139molecular_function5'-3' DNA helicase activity
B0043249biological_processerythrocyte maturation
B0043588biological_processskin development
B0045951biological_processpositive regulation of mitotic recombination
B0046872molecular_functionmetal ion binding
B0048009biological_processinsulin-like growth factor receptor signaling pathway
B0048568biological_processembryonic organ development
B0048820biological_processhair follicle maturation
B0051539molecular_function4 iron, 4 sulfur cluster binding
B0060218biological_processhematopoietic stem cell differentiation
B0070516cellular_componentCAK-ERCC2 complex
B0071425biological_processhematopoietic stem cell proliferation
B0071817cellular_componentMMXD complex
B0072332biological_processintrinsic apoptotic signaling pathway by p53 class mediator
B1901990biological_processregulation of mitotic cell cycle phase transition
C0000438cellular_componentcore TFIIH complex portion of holo TFIIH complex
C0000439cellular_componenttranscription factor TFIIH core complex
C0001671molecular_functionATPase activator activity
C0003690molecular_functiondouble-stranded DNA binding
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005669cellular_componenttranscription factor TFIID complex
C0005675cellular_componenttranscription factor TFIIH holo complex
C0006281biological_processDNA repair
C0006289biological_processnucleotide-excision repair
C0006366biological_processtranscription by RNA polymerase II
C0016251molecular_functionRNA polymerase II general transcription initiation factor activity
C0016607cellular_componentnuclear speck
D0000438cellular_componentcore TFIIH complex portion of holo TFIIH complex
D0000439cellular_componenttranscription factor TFIIH core complex
D0002031biological_processG protein-coupled receptor internalization
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005669cellular_componenttranscription factor TFIID complex
D0005675cellular_componenttranscription factor TFIIH holo complex
D0006281biological_processDNA repair
D0006289biological_processnucleotide-excision repair
D0006351biological_processDNA-templated transcription
D0006357biological_processregulation of transcription by RNA polymerase II
D0006366biological_processtranscription by RNA polymerase II
D0006367biological_processtranscription initiation at RNA polymerase II promoter
D0008270molecular_functionzinc ion binding
D0009411biological_processresponse to UV
D0016251molecular_functionRNA polymerase II general transcription initiation factor activity
D0016607cellular_componentnuclear speck
D0046872molecular_functionmetal ion binding
E0000438cellular_componentcore TFIIH complex portion of holo TFIIH complex
E0000439cellular_componenttranscription factor TFIIH core complex
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0005654cellular_componentnucleoplasm
E0005669cellular_componenttranscription factor TFIID complex
E0005675cellular_componenttranscription factor TFIIH holo complex
E0006281biological_processDNA repair
E0006289biological_processnucleotide-excision repair
E0006355biological_processregulation of DNA-templated transcription
E0006366biological_processtranscription by RNA polymerase II
E0016251molecular_functionRNA polymerase II general transcription initiation factor activity
E0046872molecular_functionmetal ion binding
E0097550cellular_componenttranscription preinitiation complex
F0000439cellular_componenttranscription factor TFIIH core complex
F0000462biological_processmaturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005669cellular_componenttranscription factor TFIID complex
F0005675cellular_componenttranscription factor TFIIH holo complex
F0005730cellular_componentnucleolus
F0005737cellular_componentcytoplasm
F0006281biological_processDNA repair
F0006289biological_processnucleotide-excision repair
F0006294biological_processnucleotide-excision repair, preincision complex assembly
F0006362biological_processtranscription elongation by RNA polymerase I
F0006366biological_processtranscription by RNA polymerase II
F0006367biological_processtranscription initiation at RNA polymerase II promoter
F0071480biological_processcellular response to gamma radiation
G0000110cellular_componentnucleotide-excision repair factor 1 complex
G0000715biological_processnucleotide-excision repair, DNA damage recognition
G0003677molecular_functionDNA binding
G0003684molecular_functiondamaged DNA binding
G0005515molecular_functionprotein binding
G0005634cellular_componentnucleus
G0005654cellular_componentnucleoplasm
G0005662cellular_componentDNA replication factor A complex
G0006281biological_processDNA repair
G0006284biological_processbase-excision repair
G0006289biological_processnucleotide-excision repair
G0009650biological_processUV protection
G0010996biological_processresponse to auditory stimulus
G0019904molecular_functionprotein domain specific binding
G0034504biological_processprotein localization to nucleus
G0042803molecular_functionprotein homodimerization activity
G0045171cellular_componentintercellular bridge
G0046872molecular_functionmetal ion binding
G0070914biological_processUV-damage excision repair
G1901255biological_processnucleotide-excision repair involved in interstrand cross-link repair
G1990837molecular_functionsequence-specific double-stranded DNA binding
Functional Information from PDB Data
site_idAC1
Number of Residues6
Detailsbinding site for residue SF4 B 1000
ChainResidue
BLEU115
BCYS116
BCYS134
BCYS155
BPHE157
BCYS190

site_idAC2
Number of Residues6
Detailsbinding site for residue ZN E 401
ChainResidue
ECYS282
ETHR284
ECYS285
ECYS268
EVAL270
ECYS271

site_idAC3
Number of Residues4
Detailsbinding site for residue ZN E 402
ChainResidue
ECYS255
ECYS257
EHIS258
ECYS276

site_idAC4
Number of Residues4
Detailsbinding site for residue ZN D 401
ChainResidue
DCYS291
DCYS294
DCYS305
DCYS308

site_idAC5
Number of Residues4
Detailsbinding site for residue ZN D 402
ChainResidue
DCYS345
DCYS348
DCYS368
DCYS371

site_idAC6
Number of Residues4
Detailsbinding site for residue ZN D 403
ChainResidue
DCYS360
DCYS363
DCYS382
DCYS385

site_idAC7
Number of Residues4
Detailsbinding site for residue ZN G 301
ChainResidue
GCYS105
GCYS108
GCYS126
GCYS129

Functional Information from PROSITE/UniProt
site_idPS00028
Number of Residues21
DetailsZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. Cav..CqnvFcvdcdvfvHdsl..H
ChainResidueDetails
DCYS360-HIS380

site_idPS00752
Number of Residues25
DetailsXPA_1 XPA protein signature 1. CeECgkeFm.DsyLmnhFdlptCdnC
ChainResidueDetails
GCYS105-CYS129

site_idPS00753
Number of Residues17
DetailsXPA_2 XPA protein signature 2. LITKTEaKqEYLLkDcD
ChainResidueDetails
GLEU138-ASP154

site_idPS00690
Number of Residues10
DetailsDEAH_ATP_HELICASE DEAH-box subfamily ATP-dependent helicases signature. AvVVFDEAHN
ChainResidueDetails
BALA229-ASN238

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues24
DetailsZN_FING:
ChainResidueDetails
GCYS105-CYS129

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: N-acetylalanine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22814378
ChainResidueDetails
GALA2
BCYS134
BCYS155

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:16540648, ECO:0007744|PubMed:23186163
ChainResidueDetails
GSER196

site_idSWS_FT_FI4
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
GLYS86
GLYS63

site_idSWS_FT_FI5
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25218447
ChainResidueDetails
GLYS145

219869

PDB entries from 2024-05-15

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