Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6RAZ

D. melanogaster CMG-DNA, State 2B

Functional Information from GO Data

Chain	GOid	namespace	contents
2	0000166	molecular_function	nucleotide binding
2	0000727	biological_process	double-strand break repair via break-induced replication
2	0003677	molecular_function	DNA binding
2	0003697	molecular_function	single-stranded DNA binding
2	0004386	molecular_function	helicase activity
2	0005515	molecular_function	protein binding
2	0005524	molecular_function	ATP binding
2	0005634	cellular_component	nucleus
2	0005694	cellular_component	chromosome
2	0006260	biological_process	DNA replication
2	0006268	biological_process	DNA unwinding involved in DNA replication
2	0006270	biological_process	DNA replication initiation
2	0006279	biological_process	premeiotic DNA replication
2	0007049	biological_process	cell cycle
2	0016787	molecular_function	hydrolase activity
2	0016887	molecular_function	ATP hydrolysis activity
2	0017116	molecular_function	single-stranded DNA helicase activity
2	0030261	biological_process	chromosome condensation
2	0032508	biological_process	DNA duplex unwinding
2	0042555	cellular_component	MCM complex
2	0043138	molecular_function	3'-5' DNA helicase activity
2	0046872	molecular_function	metal ion binding
2	0051301	biological_process	cell division
2	0071162	cellular_component	CMG complex
2	1902975	biological_process	mitotic DNA replication initiation
2	1905775	biological_process	negative regulation of DNA helicase activity
3	0000166	molecular_function	nucleotide binding
3	0000727	biological_process	double-strand break repair via break-induced replication
3	0003677	molecular_function	DNA binding
3	0003697	molecular_function	single-stranded DNA binding
3	0004386	molecular_function	helicase activity
3	0005515	molecular_function	protein binding
3	0005524	molecular_function	ATP binding
3	0005634	cellular_component	nucleus
3	0005694	cellular_component	chromosome
3	0006260	biological_process	DNA replication
3	0006270	biological_process	DNA replication initiation
3	0006271	biological_process	DNA strand elongation involved in DNA replication
3	0006279	biological_process	premeiotic DNA replication
3	0007049	biological_process	cell cycle
3	0016787	molecular_function	hydrolase activity
3	0016887	molecular_function	ATP hydrolysis activity
3	0017116	molecular_function	single-stranded DNA helicase activity
3	0032508	biological_process	DNA duplex unwinding
3	0042555	cellular_component	MCM complex
3	0071162	cellular_component	CMG complex
3	1902975	biological_process	mitotic DNA replication initiation
4	0000166	molecular_function	nucleotide binding
4	0000727	biological_process	double-strand break repair via break-induced replication
4	0003677	molecular_function	DNA binding
4	0003678	molecular_function	DNA helicase activity
4	0003697	molecular_function	single-stranded DNA binding
4	0004386	molecular_function	helicase activity
4	0005515	molecular_function	protein binding
4	0005524	molecular_function	ATP binding
4	0005634	cellular_component	nucleus
4	0006260	biological_process	DNA replication
4	0006268	biological_process	DNA unwinding involved in DNA replication
4	0006270	biological_process	DNA replication initiation
4	0006271	biological_process	DNA strand elongation involved in DNA replication
4	0006279	biological_process	premeiotic DNA replication
4	0007052	biological_process	mitotic spindle organization
4	0016787	molecular_function	hydrolase activity
4	0016887	molecular_function	ATP hydrolysis activity
4	0017116	molecular_function	single-stranded DNA helicase activity
4	0032508	biological_process	DNA duplex unwinding
4	0042555	cellular_component	MCM complex
4	0043138	molecular_function	3'-5' DNA helicase activity
4	0071162	cellular_component	CMG complex
4	1902975	biological_process	mitotic DNA replication initiation
5	0000166	molecular_function	nucleotide binding
5	0000712	biological_process	resolution of meiotic recombination intermediates
5	0000727	biological_process	double-strand break repair via break-induced replication
5	0003677	molecular_function	DNA binding
5	0003688	molecular_function	DNA replication origin binding
5	0003697	molecular_function	single-stranded DNA binding
5	0004386	molecular_function	helicase activity
5	0005515	molecular_function	protein binding
5	0005524	molecular_function	ATP binding
5	0005634	cellular_component	nucleus
5	0005737	cellular_component	cytoplasm
5	0005829	cellular_component	cytosol
5	0006260	biological_process	DNA replication
5	0006270	biological_process	DNA replication initiation
5	0006279	biological_process	premeiotic DNA replication
5	0007049	biological_process	cell cycle
5	0016787	molecular_function	hydrolase activity
5	0016887	molecular_function	ATP hydrolysis activity
5	0017116	molecular_function	single-stranded DNA helicase activity
5	0030261	biological_process	chromosome condensation
5	0032508	biological_process	DNA duplex unwinding
5	0032991	cellular_component	protein-containing complex
5	0042023	biological_process	DNA endoreduplication
5	0042555	cellular_component	MCM complex
5	0043138	molecular_function	3'-5' DNA helicase activity
5	0051321	biological_process	meiotic cell cycle
5	0071162	cellular_component	CMG complex
6	0000166	molecular_function	nucleotide binding
6	0000727	biological_process	double-strand break repair via break-induced replication
6	0003677	molecular_function	DNA binding
6	0003678	molecular_function	DNA helicase activity
6	0003697	molecular_function	single-stranded DNA binding
6	0004386	molecular_function	helicase activity
6	0005515	molecular_function	protein binding
6	0005524	molecular_function	ATP binding
6	0005634	cellular_component	nucleus
6	0006260	biological_process	DNA replication
6	0006268	biological_process	DNA unwinding involved in DNA replication
6	0006270	biological_process	DNA replication initiation
6	0006279	biological_process	premeiotic DNA replication
6	0007049	biological_process	cell cycle
6	0007307	biological_process	eggshell chorion gene amplification
6	0016787	molecular_function	hydrolase activity
6	0016887	molecular_function	ATP hydrolysis activity
6	0032508	biological_process	DNA duplex unwinding
6	0042555	cellular_component	MCM complex
6	0043138	molecular_function	3'-5' DNA helicase activity
6	0046872	molecular_function	metal ion binding
6	0051301	biological_process	cell division
6	0071162	cellular_component	CMG complex
6	1902969	biological_process	mitotic DNA replication
6	1990518	molecular_function	single-stranded 3'-5' DNA helicase activity
7	0000166	molecular_function	nucleotide binding
7	0000727	biological_process	double-strand break repair via break-induced replication
7	0003677	molecular_function	DNA binding
7	0003678	molecular_function	DNA helicase activity
7	0003697	molecular_function	single-stranded DNA binding
7	0004386	molecular_function	helicase activity
7	0005524	molecular_function	ATP binding
7	0005634	cellular_component	nucleus
7	0006260	biological_process	DNA replication
7	0006268	biological_process	DNA unwinding involved in DNA replication
7	0006270	biological_process	DNA replication initiation
7	0006271	biological_process	DNA strand elongation involved in DNA replication
7	0006279	biological_process	premeiotic DNA replication
7	0007049	biological_process	cell cycle
7	0016787	molecular_function	hydrolase activity
7	0016887	molecular_function	ATP hydrolysis activity
7	0017116	molecular_function	single-stranded DNA helicase activity
7	0032508	biological_process	DNA duplex unwinding
7	0042555	cellular_component	MCM complex
7	0043138	molecular_function	3'-5' DNA helicase activity
7	0043229	cellular_component	intracellular organelle
7	0071162	cellular_component	CMG complex
A	0000727	biological_process	double-strand break repair via break-induced replication
A	0003682	molecular_function	chromatin binding
A	0003688	molecular_function	DNA replication origin binding
A	0003697	molecular_function	single-stranded DNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0006260	biological_process	DNA replication
A	0006270	biological_process	DNA replication initiation
A	0006277	biological_process	DNA amplification
A	0007049	biological_process	cell cycle
A	0030261	biological_process	chromosome condensation
A	0031261	cellular_component	DNA replication preinitiation complex
A	0051301	biological_process	cell division
A	0071162	cellular_component	CMG complex
A	1902977	biological_process	mitotic DNA replication preinitiation complex assembly
H	0000811	cellular_component	GINS complex
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0006260	biological_process	DNA replication
H	0006270	biological_process	DNA replication initiation
H	0071162	cellular_component	CMG complex
H	1902983	biological_process	DNA strand elongation involved in mitotic DNA replication
L	0000228	cellular_component	nuclear chromosome
L	0000727	biological_process	double-strand break repair via break-induced replication
L	0000811	cellular_component	GINS complex
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0006260	biological_process	DNA replication
L	0006261	biological_process	DNA-templated DNA replication
L	0006270	biological_process	DNA replication initiation
L	0006271	biological_process	DNA strand elongation involved in DNA replication
L	0030261	biological_process	chromosome condensation
L	0032784	biological_process	regulation of DNA-templated transcription elongation
L	0032993	cellular_component	protein-DNA complex
L	0071162	cellular_component	CMG complex
M	0000811	cellular_component	GINS complex
M	0005634	cellular_component	nucleus
M	0006260	biological_process	DNA replication
M	0071162	cellular_component	CMG complex
M	1902975	biological_process	mitotic DNA replication initiation
N	0000278	biological_process	mitotic cell cycle
N	0000727	biological_process	double-strand break repair via break-induced replication
N	0000811	cellular_component	GINS complex
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0006260	biological_process	DNA replication
N	0006261	biological_process	DNA-templated DNA replication
N	0006270	biological_process	DNA replication initiation
N	0071162	cellular_component	CMG complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	binding site for residue ADP 5 801

Chain	Residue
2	GLU590
5	SER385
5	GLN386
5	ASN486
5	LEU529
5	HIS532
2	ARG641
2	VAL741
2	ARG742
5	PRO380
5	GLY381
5	THR382
5	ALA383
5	LYS384

site_id	AC2
Number of Residues	8
Details	binding site for residue ADP 6 901

Chain	Residue
2	ILE470
2	HIS473
2	GLY511
2	THR512
2	LYS514
2	SER515
2	GLN516
6	ARG611

site_id	AC3
Number of Residues	12
Details	binding site for residue ATP 6 902

Chain	Residue
4	PRO733
4	ARG734
6	ILE350
6	TYR351
6	GLY352
6	PRO390
6	SER391
6	THR392
6	ALA393
6	LYS394
6	SER395
6	GLN396

site_id	AC4
Number of Residues	7
Details	binding site for residue ATP 3 901

Chain	Residue
3	ILE302
3	SER343
3	ALA345
3	LYS346
3	SER347
3	GLN348
5	ARG510

site_id	AC5
Number of Residues	14
Details	binding site for residue ATP 4 901

Chain	Residue
4	ILE472
4	GLU474
4	PRO514
4	GLY515
4	THR516
4	SER517
4	LYS518
4	SER519
4	GLN520
4	GLU577
4	LEU664
7	ARG514
7	ALA603
7	ARG604

site_id	AC6
Number of Residues	12
Details	binding site for residue ATP 7 801

Chain	Residue
3	GLU422
3	ARG473
3	ARG610
7	GLU343
7	ILE344
7	GLY384
7	VAL385
7	ALA386
7	LYS387
7	SER388
7	LEU533
7	ILE537

Functional Information from PROSITE/UniProt

site_id	PS00847
Number of Residues	9
Details	MCM_1 MCM family signature. GVVCIDEFD

Chain	Residue	Details
5	GLY437-ASP445
7	GLY440-ASP448
2	GLY567-ASP575
6	GLY447-ASP455
4	GLY571-ASP579
3	GLY399-ASP407

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:P33993

Chain	Residue	Details
7	TYR345
7	GLY384
7	ALA386
7	LYS387
7	SER388
7	ASN489
7	ARG514
7	ARG604

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000269\|PubMed:17372656, ECO:0000269\|PubMed:18327897

Chain	Residue	Details
4	SER55
3	SER664
3	SER666
3	SER680
3	SER682
6	ASN496
6	ARG611
6	GLU614

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000269\|PubMed:18327897

Chain	Residue	Details
4	SER81

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0000269\|PubMed:18327897

Chain	Residue	Details
4	THR87
3	THR692

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000269\|PubMed:17372656, ECO:0000269\|PubMed:18327897

Chain	Residue	Details
3	SER697
2	SER92

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000269\|PubMed:17372656

Chain	Residue	Details
3	SER735
3	SER739

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)