6R7Z
CryoEM structure of calcium-free human TMEM16K / Anoctamin 10 in detergent (closed form)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005227 | molecular_function | calcium-activated cation channel activity |
| A | 0005229 | molecular_function | intracellularly calcium-gated chloride channel activity |
| A | 0005254 | molecular_function | chloride channel activity |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0016020 | cellular_component | membrane |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| A | 0043231 | cellular_component | intracellular membrane-bounded organelle |
| A | 0098655 | biological_process | monoatomic cation transmembrane transport |
| A | 1902476 | biological_process | chloride transmembrane transport |
| B | 0005227 | molecular_function | calcium-activated cation channel activity |
| B | 0005229 | molecular_function | intracellularly calcium-gated chloride channel activity |
| B | 0005254 | molecular_function | chloride channel activity |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0016020 | cellular_component | membrane |
| B | 0034220 | biological_process | monoatomic ion transmembrane transport |
| B | 0043231 | cellular_component | intracellular membrane-bounded organelle |
| B | 0098655 | biological_process | monoatomic cation transmembrane transport |
| B | 1902476 | biological_process | chloride transmembrane transport |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 730 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| A | MET1-THR207 | |
| B | ALA612-THR660 | |
| A | LYS262-LEU316 | |
| A | ASN374-LEU400 | |
| A | ALA522-GLY553 | |
| A | ALA612-THR660 | |
| B | MET1-THR207 | |
| B | LYS262-LEU316 | |
| B | ASN374-LEU400 | |
| B | ALA522-GLY553 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 320 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| A | ILE208-ILE228 | |
| B | ASP241-TRP261 | |
| B | VAL317-PHE337 | |
| B | GLU353-MET373 | |
| B | ILE401-PHE421 | |
| B | LEU501-PHE521 | |
| B | VAL554-ILE574 | |
| B | LEU591-PHE611 | |
| A | ASP241-TRP261 | |
| A | VAL317-PHE337 | |
| A | GLU353-MET373 | |
| A | ILE401-PHE421 | |
| A | LEU501-PHE521 | |
| A | VAL554-ILE574 | |
| A | LEU591-PHE611 | |
| B | ILE208-ILE228 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 236 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| A | GLY229-TYR240 | |
| A | ASP338-SER352 | |
| A | VAL422-GLU500 | |
| A | GLY575-ASP590 | |
| B | GLY229-TYR240 | |
| B | ASP338-SER352 | |
| B | VAL422-GLU500 | |
| B | GLY575-ASP590 |
