6R7X
CryoEM structure of calcium-bound human TMEM16K / Anoctamin 10 in detergent (2mM Ca2+, closed form)
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005227 | molecular_function | calcium-activated cation channel activity |
A | 0005229 | molecular_function | intracellularly calcium-gated chloride channel activity |
A | 0005254 | molecular_function | chloride channel activity |
A | 0005886 | cellular_component | plasma membrane |
A | 0016020 | cellular_component | membrane |
A | 0034220 | biological_process | monoatomic ion transmembrane transport |
A | 0043231 | cellular_component | intracellular membrane-bounded organelle |
A | 0098655 | biological_process | monoatomic cation transmembrane transport |
A | 1902476 | biological_process | chloride transmembrane transport |
B | 0005227 | molecular_function | calcium-activated cation channel activity |
B | 0005229 | molecular_function | intracellularly calcium-gated chloride channel activity |
B | 0005254 | molecular_function | chloride channel activity |
B | 0005886 | cellular_component | plasma membrane |
B | 0016020 | cellular_component | membrane |
B | 0034220 | biological_process | monoatomic ion transmembrane transport |
B | 0043231 | cellular_component | intracellular membrane-bounded organelle |
B | 0098655 | biological_process | monoatomic cation transmembrane transport |
B | 1902476 | biological_process | chloride transmembrane transport |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 5 |
Details | binding site for residue CA A 701 |
Chain | Residue |
A | ASN444 |
A | GLN445 |
A | GLU448 |
A | GLU500 |
A | GLU529 |
site_id | AC2 |
Number of Residues | 6 |
Details | binding site for residue CA A 702 |
Chain | Residue |
A | GLU529 |
A | ASP533 |
A | TYR211 |
A | GLU448 |
A | ASP497 |
A | GLU500 |
site_id | AC3 |
Number of Residues | 4 |
Details | binding site for residue CA A 703 |
Chain | Residue |
A | GLU259 |
A | ALA610 |
A | ILE613 |
A | ASP615 |
site_id | AC4 |
Number of Residues | 7 |
Details | binding site for residue PC1 A 704 |
Chain | Residue |
A | TYR315 |
A | ASN398 |
A | HIS399 |
A | LEU402 |
A | PHE409 |
A | VAL554 |
B | PHE611 |
site_id | AC5 |
Number of Residues | 6 |
Details | binding site for residue UMQ A 705 |
Chain | Residue |
A | GLY575 |
A | MET576 |
A | PRO578 |
A | ASN581 |
A | LYS588 |
B | UMQ901 |
site_id | AC6 |
Number of Residues | 2 |
Details | binding site for residue UMQ A 706 |
Chain | Residue |
A | ARG263 |
A | UMQ708 |
site_id | AC7 |
Number of Residues | 5 |
Details | binding site for residue UMQ A 707 |
Chain | Residue |
A | LYS180 |
A | GLU183 |
A | PHE450 |
A | TYR453 |
A | ARG539 |
site_id | AC8 |
Number of Residues | 1 |
Details | binding site for residue UMQ A 708 |
Chain | Residue |
A | UMQ706 |
site_id | AC9 |
Number of Residues | 3 |
Details | binding site for residue UMQ A 709 |
Chain | Residue |
A | VAL422 |
A | LYS424 |
B | UMQ901 |
site_id | AD1 |
Number of Residues | 1 |
Details | binding site for residue UMQ A 710 |
Chain | Residue |
A | PHE417 |
site_id | AD2 |
Number of Residues | 1 |
Details | binding site for residue UMQ A 711 |
Chain | Residue |
A | GLU560 |
site_id | AD3 |
Number of Residues | 7 |
Details | binding site for residue UMQ A 714 |
Chain | Residue |
A | SER587 |
A | ALA589 |
A | LEU593 |
B | LYS424 |
B | ILE592 |
B | UMQ906 |
B | UMQ910 |
site_id | AD4 |
Number of Residues | 7 |
Details | binding site for residue UMQ B 901 |
Chain | Residue |
A | LYS424 |
A | ILE592 |
A | UMQ705 |
A | UMQ709 |
B | SER587 |
B | ALA589 |
B | LEU593 |
site_id | AD5 |
Number of Residues | 5 |
Details | binding site for residue CA B 902 |
Chain | Residue |
B | ASN444 |
B | GLN445 |
B | GLU448 |
B | GLU500 |
B | GLU529 |
site_id | AD6 |
Number of Residues | 6 |
Details | binding site for residue CA B 903 |
Chain | Residue |
B | TYR211 |
B | GLU448 |
B | ASP497 |
B | GLU500 |
B | GLU529 |
B | ASP533 |
site_id | AD7 |
Number of Residues | 4 |
Details | binding site for residue CA B 904 |
Chain | Residue |
B | GLU259 |
B | ALA610 |
B | ILE613 |
B | ASP615 |
site_id | AD8 |
Number of Residues | 7 |
Details | binding site for residue PC1 B 905 |
Chain | Residue |
A | PHE611 |
B | TYR315 |
B | ASN398 |
B | HIS399 |
B | LEU402 |
B | PHE409 |
B | VAL554 |
site_id | AD9 |
Number of Residues | 6 |
Details | binding site for residue UMQ B 906 |
Chain | Residue |
A | UMQ714 |
B | GLY575 |
B | MET576 |
B | PRO578 |
B | ASN581 |
B | LYS588 |
site_id | AE1 |
Number of Residues | 2 |
Details | binding site for residue UMQ B 907 |
Chain | Residue |
B | ARG263 |
B | UMQ909 |
site_id | AE2 |
Number of Residues | 5 |
Details | binding site for residue UMQ B 908 |
Chain | Residue |
B | LYS180 |
B | GLU183 |
B | PHE450 |
B | TYR453 |
B | ARG539 |
site_id | AE3 |
Number of Residues | 1 |
Details | binding site for residue UMQ B 909 |
Chain | Residue |
B | UMQ907 |
site_id | AE4 |
Number of Residues | 3 |
Details | binding site for residue UMQ B 910 |
Chain | Residue |
A | UMQ714 |
B | VAL422 |
B | LYS424 |
site_id | AE5 |
Number of Residues | 1 |
Details | binding site for residue UMQ B 911 |
Chain | Residue |
B | PHE417 |
site_id | AE6 |
Number of Residues | 1 |
Details | binding site for residue UMQ B 912 |
Chain | Residue |
B | GLU560 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 730 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
Chain | Residue | Details |
A | MET1-THR207 | |
B | ALA612-THR660 | |
A | LYS262-LEU316 | |
A | ASN374-LEU400 | |
A | ALA522-GLY553 | |
A | ALA612-THR660 | |
B | MET1-THR207 | |
B | LYS262-LEU316 | |
B | ASN374-LEU400 | |
B | ALA522-GLY553 |
site_id | SWS_FT_FI2 |
Number of Residues | 320 |
Details | TRANSMEM: Helical => ECO:0000255 |
Chain | Residue | Details |
A | ILE208-ILE228 | |
B | ASP241-TRP261 | |
B | VAL317-PHE337 | |
B | GLU353-MET373 | |
B | ILE401-PHE421 | |
B | LEU501-PHE521 | |
B | VAL554-ILE574 | |
B | LEU591-PHE611 | |
A | ASP241-TRP261 | |
A | VAL317-PHE337 | |
A | GLU353-MET373 | |
A | ILE401-PHE421 | |
A | LEU501-PHE521 | |
A | VAL554-ILE574 | |
A | LEU591-PHE611 | |
B | ILE208-ILE228 |
site_id | SWS_FT_FI3 |
Number of Residues | 236 |
Details | TOPO_DOM: Extracellular => ECO:0000255 |
Chain | Residue | Details |
A | GLY229-TYR240 | |
A | ASP338-SER352 | |
A | VAL422-GLU500 | |
A | GLY575-ASP590 | |
B | GLY229-TYR240 | |
B | ASP338-SER352 | |
B | VAL422-GLU500 | |
B | GLY575-ASP590 |