Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6R0W

Thermus thermophilus V/A-type ATPase/synthase, rotational state 2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000325	cellular_component	plant-type vacuole
A	0000329	cellular_component	fungal-type vacuole membrane
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005765	cellular_component	lysosomal membrane
A	0006754	biological_process	ATP biosynthetic process
A	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
A	0045259	cellular_component	proton-transporting ATP synthase complex
A	0045335	cellular_component	phagocytic vesicle
A	0046034	biological_process	ATP metabolic process
A	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
A	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
A	1902600	biological_process	proton transmembrane transport
B	0000325	cellular_component	plant-type vacuole
B	0000329	cellular_component	fungal-type vacuole membrane
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005765	cellular_component	lysosomal membrane
B	0006754	biological_process	ATP biosynthetic process
B	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
B	0045259	cellular_component	proton-transporting ATP synthase complex
B	0045335	cellular_component	phagocytic vesicle
B	0046034	biological_process	ATP metabolic process
B	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
B	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
B	1902600	biological_process	proton transmembrane transport
C	0000325	cellular_component	plant-type vacuole
C	0000329	cellular_component	fungal-type vacuole membrane
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005765	cellular_component	lysosomal membrane
C	0006754	biological_process	ATP biosynthetic process
C	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
C	0045259	cellular_component	proton-transporting ATP synthase complex
C	0045335	cellular_component	phagocytic vesicle
C	0046034	biological_process	ATP metabolic process
C	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
C	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
C	1902600	biological_process	proton transmembrane transport
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0006754	biological_process	ATP biosynthetic process
D	0007035	biological_process	vacuolar acidification
D	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
D	0046034	biological_process	ATP metabolic process
D	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
D	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
D	1902600	biological_process	proton transmembrane transport
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0006754	biological_process	ATP biosynthetic process
E	0007035	biological_process	vacuolar acidification
E	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
E	0046034	biological_process	ATP metabolic process
E	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
E	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
E	1902600	biological_process	proton transmembrane transport
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0006754	biological_process	ATP biosynthetic process
F	0007035	biological_process	vacuolar acidification
F	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
F	0046034	biological_process	ATP metabolic process
F	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
F	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
F	1902600	biological_process	proton transmembrane transport
G	0000329	cellular_component	fungal-type vacuole membrane
G	0005524	molecular_function	ATP binding
G	0006754	biological_process	ATP biosynthetic process
G	0007035	biological_process	vacuolar acidification
G	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
G	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
G	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
G	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
G	1902600	biological_process	proton transmembrane transport
H	0005524	molecular_function	ATP binding
H	0006754	biological_process	ATP biosynthetic process
H	0034220	biological_process	monoatomic ion transmembrane transport
H	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
H	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
H	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
H	1902600	biological_process	proton transmembrane transport
I	0005515	molecular_function	protein binding
I	0046872	molecular_function	metal ion binding
J	0005515	molecular_function	protein binding
J	0005524	molecular_function	ATP binding
J	0006754	biological_process	ATP biosynthetic process
J	0033178	cellular_component	proton-transporting two-sector ATPase complex, catalytic domain
J	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
J	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
J	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
J	1902600	biological_process	proton transmembrane transport
K	0005515	molecular_function	protein binding
K	0046872	molecular_function	metal ion binding
L	0005515	molecular_function	protein binding
L	0005524	molecular_function	ATP binding
L	0006754	biological_process	ATP biosynthetic process
L	0033178	cellular_component	proton-transporting two-sector ATPase complex, catalytic domain
L	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
L	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
L	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
L	1902600	biological_process	proton transmembrane transport
M	0005524	molecular_function	ATP binding
M	0006754	biological_process	ATP biosynthetic process
M	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
M	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
M	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
M	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
M	1902600	biological_process	proton transmembrane transport
N	0000329	cellular_component	fungal-type vacuole membrane
N	0005886	cellular_component	plasma membrane
N	0006811	biological_process	monoatomic ion transport
N	0007035	biological_process	vacuolar acidification
N	0016020	cellular_component	membrane
N	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
N	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
N	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
N	0051117	molecular_function	ATPase binding
N	1902600	biological_process	proton transmembrane transport
O	0015078	molecular_function	proton transmembrane transporter activity
O	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
O	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
O	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
O	1902600	biological_process	proton transmembrane transport
P	0015078	molecular_function	proton transmembrane transporter activity
P	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
P	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
P	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
P	1902600	biological_process	proton transmembrane transport
Q	0015078	molecular_function	proton transmembrane transporter activity
Q	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
Q	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
Q	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
Q	1902600	biological_process	proton transmembrane transport
R	0015078	molecular_function	proton transmembrane transporter activity
R	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
R	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
R	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
R	1902600	biological_process	proton transmembrane transport
S	0015078	molecular_function	proton transmembrane transporter activity
S	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
S	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
S	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
S	1902600	biological_process	proton transmembrane transport
T	0015078	molecular_function	proton transmembrane transporter activity
T	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
T	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
T	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
T	1902600	biological_process	proton transmembrane transport
U	0015078	molecular_function	proton transmembrane transporter activity
U	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
U	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
U	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
U	1902600	biological_process	proton transmembrane transport
V	0015078	molecular_function	proton transmembrane transporter activity
V	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
V	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
V	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
V	1902600	biological_process	proton transmembrane transport
W	0015078	molecular_function	proton transmembrane transporter activity
W	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
W	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
W	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
W	1902600	biological_process	proton transmembrane transport
X	0015078	molecular_function	proton transmembrane transporter activity
X	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
X	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
X	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
X	1902600	biological_process	proton transmembrane transport
Y	0015078	molecular_function	proton transmembrane transporter activity
Y	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
Y	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
Y	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
Y	1902600	biological_process	proton transmembrane transport
Z	0015078	molecular_function	proton transmembrane transporter activity
Z	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
Z	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
Z	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
Z	1902600	biological_process	proton transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue MG C 601

Chain	Residue
C	LYS234
C	THR235
C	GLU257
C	ARG258
C	ADP602

site_id	AC2
Number of Residues	15
Details	binding site for residue ADP C 602

Chain	Residue
C	THR235
C	VAL236
C	GLU261
C	PHE419
C	GLN497
C	ASN498
C	ALA499
C	TYR500
C	MG601
E	ARG360
E	ASN363
C	GLY231
C	SER232
C	GLY233
C	LYS234

site_id	AC3
Number of Residues	10
Details	binding site for residue ADP E 501

Chain	Residue
C	LYS8
C	ALA10
C	ALA13
C	ILE15
C	SER339
C	ARG340
E	PHE20
E	GLU49
E	ARG274
E	GLU275

Functional Information from PROSITE/UniProt

site_id	PS00152
Number of Residues	10
Details	ATPASE_ALPHA_BETA ATP synthase alpha and beta subunits signature. PPIDPLPSLS

Chain	Residue	Details
D	PRO350-SER359
A	PRO420-SER429

site_id	PS00626
Number of Residues	11
Details	RCC1_2 Regulator of chromosome condensation (RCC1) signature 2. VSAGaEHTLSL

Chain	Residue	Details
N	VAL59-LEU69

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	BINDING: BINDING => ECO:0000255

Chain	Residue	Details
A	GLY228
B	GLY228
C	GLY228

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)