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6PZT

cryo-EM structure of human NKCC1

Functional Information from GO Data
ChainGOidnamespacecontents
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006813biological_processpotassium ion transport
A0006814biological_processsodium ion transport
A0006821biological_processchloride transport
A0006883biological_processintracellular sodium ion homeostasis
A0006884biological_processcell volume homeostasis
A0006972biological_processhyperosmotic response
A0007214biological_processgamma-aminobutyric acid signaling pathway
A0008511molecular_functionsodium:potassium:chloride symporter activity
A0008519molecular_functionammonium transmembrane transporter activity
A0009925cellular_componentbasal plasma membrane
A0010818biological_processT cell chemotaxis
A0015079molecular_functionpotassium ion transmembrane transporter activity
A0015293molecular_functionsymporter activity
A0015377molecular_functionchloride:monoatomic cation symporter activity
A0016020cellular_componentmembrane
A0016323cellular_componentbasolateral plasma membrane
A0016324cellular_componentapical plasma membrane
A0016328cellular_componentlateral plasma membrane
A0019901molecular_functionprotein kinase binding
A0022857molecular_functiontransmembrane transporter activity
A0030007biological_processintracellular potassium ion homeostasis
A0030321biological_processtransepithelial chloride transport
A0030644biological_processintracellular chloride ion homeostasis
A0030659cellular_componentcytoplasmic vesicle membrane
A0031253cellular_componentcell projection membrane
A0035633biological_processmaintenance of blood-brain barrier
A0035725biological_processsodium ion transmembrane transport
A0035865biological_processcellular response to potassium ion
A0042995cellular_componentcell projection
A0043005cellular_componentneuron projection
A0043025cellular_componentneuronal cell body
A0044297cellular_componentcell body
A0044298cellular_componentcell body membrane
A0045795biological_processpositive regulation of cell volume
A0046873molecular_functionmetal ion transmembrane transporter activity
A0051087molecular_functionprotein-folding chaperone binding
A0051879molecular_functionHsp90 protein binding
A0055064biological_processchloride ion homeostasis
A0055075biological_processpotassium ion homeostasis
A0055078biological_processsodium ion homeostasis
A0055085biological_processtransmembrane transport
A0061044biological_processnegative regulation of vascular wound healing
A0070062cellular_componentextracellular exosome
A0070634biological_processtransepithelial ammonium transport
A0071944cellular_componentcell periphery
A0072488biological_processammonium transmembrane transport
A0098658biological_processinorganic anion import across plasma membrane
A0098659biological_processinorganic cation import across plasma membrane
A0098719biological_processsodium ion import across plasma membrane
A0150003biological_processregulation of spontaneous synaptic transmission
A0150104biological_processtransport across blood-brain barrier
A1902476biological_processchloride transmembrane transport
A1903561cellular_componentextracellular vesicle
A1904450biological_processpositive regulation of aspartate secretion
A1904464biological_processregulation of matrix metallopeptidase secretion
A1990573biological_processpotassium ion import across plasma membrane
A1990869biological_processcellular response to chemokine
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006813biological_processpotassium ion transport
B0006814biological_processsodium ion transport
B0006821biological_processchloride transport
B0006883biological_processintracellular sodium ion homeostasis
B0006884biological_processcell volume homeostasis
B0006972biological_processhyperosmotic response
B0007214biological_processgamma-aminobutyric acid signaling pathway
B0008511molecular_functionsodium:potassium:chloride symporter activity
B0008519molecular_functionammonium transmembrane transporter activity
B0009925cellular_componentbasal plasma membrane
B0010818biological_processT cell chemotaxis
B0015079molecular_functionpotassium ion transmembrane transporter activity
B0015293molecular_functionsymporter activity
B0015377molecular_functionchloride:monoatomic cation symporter activity
B0016020cellular_componentmembrane
B0016323cellular_componentbasolateral plasma membrane
B0016324cellular_componentapical plasma membrane
B0016328cellular_componentlateral plasma membrane
B0019901molecular_functionprotein kinase binding
B0022857molecular_functiontransmembrane transporter activity
B0030007biological_processintracellular potassium ion homeostasis
B0030321biological_processtransepithelial chloride transport
B0030644biological_processintracellular chloride ion homeostasis
B0030659cellular_componentcytoplasmic vesicle membrane
B0031253cellular_componentcell projection membrane
B0035633biological_processmaintenance of blood-brain barrier
B0035725biological_processsodium ion transmembrane transport
B0035865biological_processcellular response to potassium ion
B0042995cellular_componentcell projection
B0043005cellular_componentneuron projection
B0043025cellular_componentneuronal cell body
B0044297cellular_componentcell body
B0044298cellular_componentcell body membrane
B0045795biological_processpositive regulation of cell volume
B0046873molecular_functionmetal ion transmembrane transporter activity
B0051087molecular_functionprotein-folding chaperone binding
B0051879molecular_functionHsp90 protein binding
B0055064biological_processchloride ion homeostasis
B0055075biological_processpotassium ion homeostasis
B0055078biological_processsodium ion homeostasis
B0055085biological_processtransmembrane transport
B0061044biological_processnegative regulation of vascular wound healing
B0070062cellular_componentextracellular exosome
B0070634biological_processtransepithelial ammonium transport
B0071944cellular_componentcell periphery
B0072488biological_processammonium transmembrane transport
B0098658biological_processinorganic anion import across plasma membrane
B0098659biological_processinorganic cation import across plasma membrane
B0098719biological_processsodium ion import across plasma membrane
B0150003biological_processregulation of spontaneous synaptic transmission
B0150104biological_processtransport across blood-brain barrier
B1902476biological_processchloride transmembrane transport
B1903561cellular_componentextracellular vesicle
B1904450biological_processpositive regulation of aspartate secretion
B1904464biological_processregulation of matrix metallopeptidase secretion
B1990573biological_processpotassium ion import across plasma membrane
B1990869biological_processcellular response to chemokine
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues570
DetailsTOPO_DOM: Cytoplasmic => ECO:0000305
ChainResidueDetails
BMET1-GLY286
AMET1-GLY286

site_idSWS_FT_FI2
Number of Residues92
DetailsTRANSMEM: Discontinuously helical => ECO:0000305|PubMed:32081947, ECO:0000305|PubMed:33597714
ChainResidueDetails
BTRP287-GLY313
BPHE487-ILE507
ATRP287-GLY313
APHE487-ILE507

site_idSWS_FT_FI3
Number of Residues68
DetailsINTRAMEM: Helical => ECO:0000305|PubMed:32081947
ChainResidueDetails
BTRP287-ILE299
BLEU308-GLY313
BPHE487-ALA498
BILE501-ILE507
ATRP287-ILE299
ALEU308-GLY313
APHE487-ALA498
AILE501-ILE507

site_idSWS_FT_FI4
Number of Residues16
DetailsINTRAMEM: INTRAMEM => ECO:0000305|PubMed:32081947
ChainResidueDetails
BTRP300-ARG307
BTHR499-GLY500
ATRP300-ARG307
ATHR499-GLY500

site_idSWS_FT_FI5
Number of Residues208
DetailsTOPO_DOM: Extracellular => ECO:0000305|PubMed:32081947, ECO:0000305|PubMed:33597714
ChainResidueDetails
AALA669-GLU670
AASN731
BGLN314-VAL321
BHIS398-ILE406
BILE455-THR486
BCYS543-PHE599
BALA669-GLU670
AGLN314-VAL321
AHIS398-ILE406
AILE455-THR486
ACYS543-PHE599
BASN731

site_idSWS_FT_FI6
Number of Residues466
DetailsTRANSMEM: Helical => ECO:0000305|PubMed:32081947, ECO:0000305|PubMed:33597714
ChainResidueDetails
AGLY654-ILE668
BLEU322-THR343
BPRO362-GLU397
BASN407-SER424
BTRP430-PHE454
BGLN515-SER542
BTHR600-ASP632
BGLY654-ILE668
BLEU671-SER697
BASN712-ILE730
BTRP732-TYR751
ALEU322-THR343
APRO362-GLU397
AASN407-SER424
ATRP430-PHE454
AGLN515-SER542
ATHR600-ASP632
ALEU671-SER697
AASN712-ILE730
ATRP732-TYR751

site_idSWS_FT_FI7
Number of Residues1040
DetailsTOPO_DOM: Cytoplasmic => ECO:0000305|PubMed:32081947, ECO:0000305|PubMed:33597714
ChainResidueDetails
BSER508-PRO514
BASN633-ARG653
BLEU698-TYR711
BLYS752-SER1212
AASN344-GLY361
AVAL425-GLU429
ASER508-PRO514
AASN633-ARG653
ALEU698-TYR711
ALYS752-SER1212
BVAL425-GLU429
BASN344-GLY361

site_idSWS_FT_FI8
Number of Residues2
DetailsMOD_RES: N-acetylmethionine => ECO:0007744|PubMed:22223895
ChainResidueDetails
BMET1
AMET1

site_idSWS_FT_FI9
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163
ChainResidueDetails
BSER77
ASER77

site_idSWS_FT_FI10
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648
ChainResidueDetails
BSER79
ASER79

site_idSWS_FT_FI11
Number of Residues4
DetailsMOD_RES: Phosphothreonine; by OXSR1 and STK39 => ECO:0000269|PubMed:16669787
ChainResidueDetails
ATHR203
ATHR207
BTHR203
BTHR207

site_idSWS_FT_FI12
Number of Residues2
DetailsMOD_RES: Phosphothreonine; by OXSR1 and STK39 => ECO:0000269|PubMed:12145305, ECO:0000269|PubMed:16669787
ChainResidueDetails
BTHR212
ATHR212

site_idSWS_FT_FI13
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0000269|PubMed:12145305, ECO:0007744|PubMed:23186163
ChainResidueDetails
BTHR217
ATHR217

site_idSWS_FT_FI14
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P55016
ChainResidueDetails
BTHR230
ATHR230

site_idSWS_FT_FI15
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P55016
ChainResidueDetails
BSER242
ASER242

site_idSWS_FT_FI16
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P55012
ChainResidueDetails
BTHR266
ATHR266

site_idSWS_FT_FI17
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
BSER940
BSER994
ASER940
ASER994

site_idSWS_FT_FI18
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P55012
ChainResidueDetails
BSER944
ASER944

219869

PDB entries from 2024-05-15

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