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6PW2

Structural Basis for Cooperative Binding of EBNA1 to the Epstein-Barr Virus Dyad Symmetry Minimal Origin of Replication

Functional Information from GO Data
ChainGOidnamespacecontents
A0003677molecular_functionDNA binding
A0003700molecular_functionDNA-binding transcription factor activity
A0006275biological_processregulation of DNA replication
A0006355biological_processregulation of DNA-templated transcription
A0042025cellular_componenthost cell nucleus
A0045893biological_processpositive regulation of DNA-templated transcription
B0003677molecular_functionDNA binding
B0003700molecular_functionDNA-binding transcription factor activity
B0006275biological_processregulation of DNA replication
B0006355biological_processregulation of DNA-templated transcription
B0042025cellular_componenthost cell nucleus
B0045893biological_processpositive regulation of DNA-templated transcription
C0003677molecular_functionDNA binding
C0003700molecular_functionDNA-binding transcription factor activity
C0006275biological_processregulation of DNA replication
C0006355biological_processregulation of DNA-templated transcription
C0042025cellular_componenthost cell nucleus
C0045893biological_processpositive regulation of DNA-templated transcription
D0003677molecular_functionDNA binding
D0003700molecular_functionDNA-binding transcription factor activity
D0006275biological_processregulation of DNA replication
D0006355biological_processregulation of DNA-templated transcription
D0042025cellular_componenthost cell nucleus
D0045893biological_processpositive regulation of DNA-templated transcription
I0003677molecular_functionDNA binding
I0003700molecular_functionDNA-binding transcription factor activity
I0006275biological_processregulation of DNA replication
I0006355biological_processregulation of DNA-templated transcription
I0042025cellular_componenthost cell nucleus
I0045893biological_processpositive regulation of DNA-templated transcription
J0003677molecular_functionDNA binding
J0003700molecular_functionDNA-binding transcription factor activity
J0006275biological_processregulation of DNA replication
J0006355biological_processregulation of DNA-templated transcription
J0042025cellular_componenthost cell nucleus
J0045893biological_processpositive regulation of DNA-templated transcription
K0003677molecular_functionDNA binding
K0003700molecular_functionDNA-binding transcription factor activity
K0006275biological_processregulation of DNA replication
K0006355biological_processregulation of DNA-templated transcription
K0042025cellular_componenthost cell nucleus
K0045893biological_processpositive regulation of DNA-templated transcription
L0003677molecular_functionDNA binding
L0003700molecular_functionDNA-binding transcription factor activity
L0006275biological_processregulation of DNA replication
L0006355biological_processregulation of DNA-templated transcription
L0042025cellular_componenthost cell nucleus
L0045893biological_processpositive regulation of DNA-templated transcription
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsACT_SITE: For site-specific DNA endonuclease activity => ECO:0000269|PubMed:33482082
ChainResidueDetails
ATYR518
BTYR518
CTYR518
DTYR518
ITYR518
JTYR518
KTYR518
LTYR518

site_idSWS_FT_FI2
Number of Residues8
DetailsBINDING: BINDING => ECO:0000269|PubMed:36037477
ChainResidueDetails
ALYS461
BLYS461
CLYS461
DLYS461
ILYS461
JLYS461
KLYS461
LLYS461

site_idSWS_FT_FI3
Number of Residues8
DetailsBINDING: covalent => ECO:0000269|PubMed:33482082
ChainResidueDetails
ATYR518
BTYR518
CTYR518
DTYR518
ITYR518
JTYR518
KTYR518
LTYR518

site_idSWS_FT_FI4
Number of Residues8
DetailsSITE: Interaction dimer-dimer => ECO:0000269|PubMed:31142669
ChainResidueDetails
AARG491
BARG491
CARG491
DARG491
IARG491
JARG491
KARG491
LARG491

site_idSWS_FT_FI5
Number of Residues8
DetailsSITE: Interaction dimer-dimer. Required for episome maintenance and generation of immortalized B cells in the host => ECO:0000269|PubMed:31142669, ECO:0000269|PubMed:33482082
ChainResidueDetails
ATYR518
BTYR518
CTYR518
DTYR518
ITYR518
JTYR518
KTYR518
LTYR518

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PDB entries from 2024-06-12

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