6PUY

Structure of HIV cleaved synaptic complex (CSC) intasome bound with magnesium and INSTI XZ426 (compound 4d)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0003677	molecular_function	DNA binding
A	0004521	molecular_function	RNA endonuclease activity
A	0005737	cellular_component	cytoplasm
A	0008270	molecular_function	zinc ion binding
A	0015074	biological_process	DNA integration
B	0003676	molecular_function	nucleic acid binding
B	0003677	molecular_function	DNA binding
B	0004521	molecular_function	RNA endonuclease activity
B	0005737	cellular_component	cytoplasm
B	0008270	molecular_function	zinc ion binding
B	0015074	biological_process	DNA integration
C	0003676	molecular_function	nucleic acid binding
C	0003677	molecular_function	DNA binding
C	0004521	molecular_function	RNA endonuclease activity
C	0005737	cellular_component	cytoplasm
C	0008270	molecular_function	zinc ion binding
C	0015074	biological_process	DNA integration
D	0003676	molecular_function	nucleic acid binding
D	0003677	molecular_function	DNA binding
D	0004521	molecular_function	RNA endonuclease activity
D	0005737	cellular_component	cytoplasm
D	0008270	molecular_function	zinc ion binding
D	0015074	biological_process	DNA integration

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue MG A 301

Chain	Residue
A	ASP64
A	ASP116
A	OZ1304
A	HOH413
A	HOH414

---

site_id	AC2
Number of Residues	6
Details	binding site for residue MG A 302

Chain	Residue
F	DA21
F	HOH101
A	ASP64
A	GLU152
A	ASN155
A	OZ1304

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN A 303

Chain	Residue
A	HIS12
A	HIS16
A	CYS40
A	CYS43

---

site_id	AC4
Number of Residues	15
Details	binding site for residue OZ1 A 304

Chain	Residue
A	ASP64
A	ASP116
A	ASN117
A	TYR143
A	PRO145
A	GLN146
A	GLU152
A	MG301
A	MG302
A	HOH413
A	HOH414
E	DG18
F	DC20
F	DA21
F	HOH101

---

site_id	AC5
Number of Residues	4
Details	binding site for residue ZN B 500

Chain	Residue
B	HIS12
B	HIS16
B	CYS40
B	CYS43

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	MOD_RES: N6-methyllysine => ECO:0000269|PubMed:3132977, ECO:0000269|PubMed:9720912

Chain	Residue	Details
A	LYS-70
A	LYS-68
A	LYS-14
A	LYS-12
A	LYS-11
B	LYS-70
B	LYS-68
B	LYS-14
B	LYS-12
B	LYS-11
C	LYS-70
C	LYS-68
C	LYS-14
C	LYS-12
C	LYS-11
D	LYS-70
D	LYS-68
D	LYS-14
D	LYS-12
D	LYS-11

---

site_id	SWS_FT_FI2
Number of Residues	164
Details	ZN_FING: Integrase-type => ECO:0000255|PROSITE-ProRule:PRU00450

Chain	Residue	Details
C	ASP3-GLN44
D	ASP3-GLN44
B	ASP3-GLN44
A	ASP3-GLN44

---

site_id	SWS_FT_FI3
Number of Residues	188
Details	DNA_BIND: Integrase-type => ECO:0000255|PROSITE-ProRule:PRU00506

Chain	Residue	Details
C	PHE223-ASP270
D	PHE223-ASP270
A	PHE223-ASP270
B	PHE223-ASP270

---

site_id	SWS_FT_FI4
Number of Residues	16
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00450

Chain	Residue	Details
C	HIS16
C	CYS40
C	CYS43
D	HIS12
D	HIS16
D	CYS40
D	CYS43
C	HIS12
A	HIS12
A	HIS16
A	CYS40
A	CYS43
B	HIS12
B	HIS16
B	CYS40
B	CYS43

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	BINDING:

Chain	Residue	Details
C	ASP64
C	ASP116
D	ASP64
D	ASP116
A	ASP64
A	ASP116
B	ASP64
B	ASP116

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P04585

Chain	Residue	Details
C	GLU152
D	GLU152
A	GLU152
B	GLU152

---