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6PDZ

Crystal structure of PPARgamma ligand binding domain in complex with SMRT peptide and inverse agonist T0070907

Functional Information from GO Data
ChainGOidnamespacecontents
A0003677molecular_functionDNA binding
A0004879molecular_functionnuclear receptor activity
A0005634cellular_componentnucleus
A0006355biological_processregulation of DNA-templated transcription
B0003677molecular_functionDNA binding
B0004879molecular_functionnuclear receptor activity
B0005634cellular_componentnucleus
B0006355biological_processregulation of DNA-templated transcription
Functional Information from PDB Data
site_idAC1
Number of Residues14
Detailsbinding site for residue EEY B 501
ChainResidue
BILE281
BHIS449
BTYR473
BLEU476
BTYR477
BHOH623
BPHE282
BCYS285
BGLN286
BHIS323
BTYR327
BPHE363
BMET364
BLYS367

site_idAC2
Number of Residues22
Detailsbinding site for Di-peptide EEY A 501 and CYS A 285
ChainResidue
APHE282
AGLN283
AGLY284
AGLN286
APHE287
AARG288
ASER289
AHIS323
ATYR327
APHE363
AMET364
ALYS367
AHIS449
ALEU452
ATYR473
ALYS474
ALEU476
ATYR477
AHOH666
AHOH668
AHOH697
AHOH704

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsBINDING: BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG
ChainResidueDetails
AHIS449
ATYR473
BGLN286
BHIS323
BHIS449
BTYR473
AGLN286
AHIS323

site_idSWS_FT_FI2
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36737649
ChainResidueDetails
BLYS224
ALYS224

219869

PDB entries from 2024-05-15

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