Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6P4X

Crystal Structure of the S. cerevisiae glucokinase, Glk1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001678	biological_process	intracellular glucose homeostasis
A	0004340	molecular_function	glucokinase activity
A	0004396	molecular_function	hexokinase activity
A	0005524	molecular_function	ATP binding
A	0005536	molecular_function	glucose binding
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0005975	biological_process	carbohydrate metabolic process
A	0006006	biological_process	glucose metabolic process
A	0006013	biological_process	mannose metabolic process
A	0006091	biological_process	generation of precursor metabolites and energy
A	0006096	biological_process	glycolytic process
A	0008865	molecular_function	fructokinase activity
A	0016301	molecular_function	kinase activity
A	0016773	molecular_function	phosphotransferase activity, alcohol group as acceptor
A	0019318	biological_process	hexose metabolic process
A	0019637	biological_process	organophosphate metabolic process
A	0046323	biological_process	glucose import
A	0046835	biological_process	carbohydrate phosphorylation
A	0051156	biological_process	glucose 6-phosphate metabolic process
A	1901135	biological_process	carbohydrate derivative metabolic process
B	0001678	biological_process	intracellular glucose homeostasis
B	0004340	molecular_function	glucokinase activity
B	0004396	molecular_function	hexokinase activity
B	0005524	molecular_function	ATP binding
B	0005536	molecular_function	glucose binding
B	0005739	cellular_component	mitochondrion
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0005975	biological_process	carbohydrate metabolic process
B	0006006	biological_process	glucose metabolic process
B	0006013	biological_process	mannose metabolic process
B	0006091	biological_process	generation of precursor metabolites and energy
B	0006096	biological_process	glycolytic process
B	0008865	molecular_function	fructokinase activity
B	0016301	molecular_function	kinase activity
B	0016773	molecular_function	phosphotransferase activity, alcohol group as acceptor
B	0019318	biological_process	hexose metabolic process
B	0019637	biological_process	organophosphate metabolic process
B	0046323	biological_process	glucose import
B	0046835	biological_process	carbohydrate phosphorylation
B	0051156	biological_process	glucose 6-phosphate metabolic process
B	1901135	biological_process	carbohydrate derivative metabolic process
C	0001678	biological_process	intracellular glucose homeostasis
C	0004340	molecular_function	glucokinase activity
C	0004396	molecular_function	hexokinase activity
C	0005524	molecular_function	ATP binding
C	0005536	molecular_function	glucose binding
C	0005739	cellular_component	mitochondrion
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0005975	biological_process	carbohydrate metabolic process
C	0006006	biological_process	glucose metabolic process
C	0006013	biological_process	mannose metabolic process
C	0006091	biological_process	generation of precursor metabolites and energy
C	0006096	biological_process	glycolytic process
C	0008865	molecular_function	fructokinase activity
C	0016301	molecular_function	kinase activity
C	0016773	molecular_function	phosphotransferase activity, alcohol group as acceptor
C	0019318	biological_process	hexose metabolic process
C	0019637	biological_process	organophosphate metabolic process
C	0046323	biological_process	glucose import
C	0046835	biological_process	carbohydrate phosphorylation
C	0051156	biological_process	glucose 6-phosphate metabolic process
C	1901135	biological_process	carbohydrate derivative metabolic process
D	0001678	biological_process	intracellular glucose homeostasis
D	0004340	molecular_function	glucokinase activity
D	0004396	molecular_function	hexokinase activity
D	0005524	molecular_function	ATP binding
D	0005536	molecular_function	glucose binding
D	0005739	cellular_component	mitochondrion
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0005975	biological_process	carbohydrate metabolic process
D	0006006	biological_process	glucose metabolic process
D	0006013	biological_process	mannose metabolic process
D	0006091	biological_process	generation of precursor metabolites and energy
D	0006096	biological_process	glycolytic process
D	0008865	molecular_function	fructokinase activity
D	0016301	molecular_function	kinase activity
D	0016773	molecular_function	phosphotransferase activity, alcohol group as acceptor
D	0019318	biological_process	hexose metabolic process
D	0019637	biological_process	organophosphate metabolic process
D	0046323	biological_process	glucose import
D	0046835	biological_process	carbohydrate phosphorylation
D	0051156	biological_process	glucose 6-phosphate metabolic process
D	1901135	biological_process	carbohydrate derivative metabolic process
E	0001678	biological_process	intracellular glucose homeostasis
E	0004340	molecular_function	glucokinase activity
E	0004396	molecular_function	hexokinase activity
E	0005524	molecular_function	ATP binding
E	0005536	molecular_function	glucose binding
E	0005739	cellular_component	mitochondrion
E	0005829	cellular_component	cytosol
E	0005886	cellular_component	plasma membrane
E	0005975	biological_process	carbohydrate metabolic process
E	0006006	biological_process	glucose metabolic process
E	0006013	biological_process	mannose metabolic process
E	0006091	biological_process	generation of precursor metabolites and energy
E	0006096	biological_process	glycolytic process
E	0008865	molecular_function	fructokinase activity
E	0016301	molecular_function	kinase activity
E	0016773	molecular_function	phosphotransferase activity, alcohol group as acceptor
E	0019318	biological_process	hexose metabolic process
E	0019637	biological_process	organophosphate metabolic process
E	0046323	biological_process	glucose import
E	0046835	biological_process	carbohydrate phosphorylation
E	0051156	biological_process	glucose 6-phosphate metabolic process
E	1901135	biological_process	carbohydrate derivative metabolic process
F	0001678	biological_process	intracellular glucose homeostasis
F	0004340	molecular_function	glucokinase activity
F	0004396	molecular_function	hexokinase activity
F	0005524	molecular_function	ATP binding
F	0005536	molecular_function	glucose binding
F	0005739	cellular_component	mitochondrion
F	0005829	cellular_component	cytosol
F	0005886	cellular_component	plasma membrane
F	0005975	biological_process	carbohydrate metabolic process
F	0006006	biological_process	glucose metabolic process
F	0006013	biological_process	mannose metabolic process
F	0006091	biological_process	generation of precursor metabolites and energy
F	0006096	biological_process	glycolytic process
F	0008865	molecular_function	fructokinase activity
F	0016301	molecular_function	kinase activity
F	0016773	molecular_function	phosphotransferase activity, alcohol group as acceptor
F	0019318	biological_process	hexose metabolic process
F	0019637	biological_process	organophosphate metabolic process
F	0046323	biological_process	glucose import
F	0046835	biological_process	carbohydrate phosphorylation
F	0051156	biological_process	glucose 6-phosphate metabolic process
F	1901135	biological_process	carbohydrate derivative metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue PO4 A 601

Chain	Residue
A	ARG416
A	SER461
A	MET462
A	HIS465
C	HIS441
C	LYS479

site_id	AC2
Number of Residues	2
Details	binding site for residue PO4 A 602

Chain	Residue
A	ARG360
A	ARG396

site_id	AC3
Number of Residues	2
Details	binding site for residue PO4 A 603

Chain	Residue
A	SER451
A	THR252

site_id	AC4
Number of Residues	5
Details	binding site for residue PO4 B 601

Chain	Residue
B	ARG416
B	SER461
B	MET462
B	HIS465
E	HIS441

site_id	AC5
Number of Residues	3
Details	binding site for residue PO4 B 602

Chain	Residue
B	GLY251
B	THR252
B	SER451

site_id	AC6
Number of Residues	5
Details	binding site for residue PO4 C 601

Chain	Residue
A	HIS441
C	ARG416
C	SER461
C	MET462
C	HIS465

site_id	AC7
Number of Residues	4
Details	binding site for residue PO4 C 602

Chain	Residue
C	GLY251
C	THR252
C	GLY450
C	SER451

site_id	AC8
Number of Residues	7
Details	binding site for residue PO4 D 601

Chain	Residue
D	ARG416
D	SER461
D	MET462
D	HIS465
F	TYR440
F	HIS441
F	ARG478

site_id	AC9
Number of Residues	4
Details	binding site for residue PO4 D 602

Chain	Residue
D	GLY251
D	THR252
D	GLY450
D	SER451

site_id	AD1
Number of Residues	6
Details	binding site for residue PO4 E 601

Chain	Residue
B	HIS441
B	LYS479
E	ARG416
E	SER461
E	MET462
E	HIS465

site_id	AD2
Number of Residues	3
Details	binding site for residue PO4 E 602

Chain	Residue
E	THR252
E	GLY450
E	SER451

site_id	AD3
Number of Residues	5
Details	binding site for residue PO4 F 601

Chain	Residue
D	TYR440
D	HIS441
F	ARG416
F	SER461
F	HIS465

site_id	AD4
Number of Residues	4
Details	binding site for residue PO4 F 602

Chain	Residue
F	GLY251
F	THR252
F	GLY450
F	SER451

Functional Information from PROSITE/UniProt

site_id	PS00378
Number of Residues	26
Details	HEXOKINASE_1 Hexokinase domain signature. LGFTFSYPvdqtsLNsgtLirWTKgF

Chain	Residue	Details
A	LEU159-PHE184

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	BINDING: BINDING => ECO:0000255

Chain	Residue	Details
D	LYS110
D	ASP487
E	LYS110
E	ASP487
F	LYS110
F	ASP487
A	LYS110
A	ASP487
B	LYS110
B	ASP487
C	LYS110
C	ASP487

site_id	SWS_FT_FI2
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:15665377

Chain	Residue	Details
B	SER2
C	SER2
D	SER2
E	SER2
F	SER2
A	SER2

site_id	SWS_FT_FI3
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:18407956

Chain	Residue	Details
C	SER470
D	SER470
E	SER470
F	SER470
A	SER470
B	SER470

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)