6NVJ

FGFR4 complex with N-(2-((5-((2,6-dichloro-3,5-dimethoxybenzyl)oxy)pyrimidin-2-yl)amino)-3-fluorophenyl)acrylamide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004713	molecular_function	protein tyrosine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue SO4 A 801

Chain	Residue
A	LYS555
A	ARG565
A	ASN615

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site_id	AC2
Number of Residues	3
Details	binding site for residue SO4 A 802

Chain	Residue
A	ARG701
A	PRO703
A	HIS704

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site_id	AC3
Number of Residues	4
Details	binding site for residue SO4 A 803

Chain	Residue
A	SER679
A	ARG563
A	ARG566
A	GLY678

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site_id	AC4
Number of Residues	3
Details	binding site for residue SO4 A 804

Chain	Residue
A	ARG698
A	HIS718
A	ALA719

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site_id	AC5
Number of Residues	16
Details	binding site for residue XL5 A 805

Chain	Residue
A	LEU473
A	VAL481
A	ARG483
A	GLU520
A	MET524
A	ILE534
A	VAL548
A	VAL550
A	GLU551
A	CYS552
A	ALA553
A	GLY556
A	LEU610
A	ALA620
A	ASP621
A	PHE622

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	31
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGCFGQVVrAeafgmdparpdqast...VAVK

Chain	Residue	Details
A	LEU473-LYS503

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site_id	PS00109
Number of Residues	13
Details	PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. CIHrDLAARNVLV

Chain	Residue	Details
A	CYS599-VAL611

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028

Chain	Residue	Details
A	THR612

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site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	LYS503
A	LEU473

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
A	GLY573

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site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:18670643

Chain	Residue	Details
A	PRO643
A	LEU642

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