Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6NVA

Crystal structure of Escherichia coli dihydrodipicolinate synthase and propionate covalently bound to K161.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0008700	molecular_function	4-hydroxy-2-oxoglutarate aldolase activity
A	0008840	molecular_function	4-hydroxy-tetrahydrodipicolinate synthase activity
A	0009085	biological_process	lysine biosynthetic process
A	0009089	biological_process	lysine biosynthetic process via diaminopimelate
A	0009436	biological_process	glyoxylate catabolic process
A	0016829	molecular_function	lyase activity
A	0019877	biological_process	diaminopimelate biosynthetic process
A	0044281	biological_process	small molecule metabolic process
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0008700	molecular_function	4-hydroxy-2-oxoglutarate aldolase activity
B	0008840	molecular_function	4-hydroxy-tetrahydrodipicolinate synthase activity
B	0009085	biological_process	lysine biosynthetic process
B	0009089	biological_process	lysine biosynthetic process via diaminopimelate
B	0009436	biological_process	glyoxylate catabolic process
B	0016829	molecular_function	lyase activity
B	0019877	biological_process	diaminopimelate biosynthetic process
B	0044281	biological_process	small molecule metabolic process
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0008700	molecular_function	4-hydroxy-2-oxoglutarate aldolase activity
C	0008840	molecular_function	4-hydroxy-tetrahydrodipicolinate synthase activity
C	0009085	biological_process	lysine biosynthetic process
C	0009089	biological_process	lysine biosynthetic process via diaminopimelate
C	0009436	biological_process	glyoxylate catabolic process
C	0016829	molecular_function	lyase activity
C	0019877	biological_process	diaminopimelate biosynthetic process
C	0044281	biological_process	small molecule metabolic process
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0008700	molecular_function	4-hydroxy-2-oxoglutarate aldolase activity
D	0008840	molecular_function	4-hydroxy-tetrahydrodipicolinate synthase activity
D	0009085	biological_process	lysine biosynthetic process
D	0009089	biological_process	lysine biosynthetic process via diaminopimelate
D	0009436	biological_process	glyoxylate catabolic process
D	0016829	molecular_function	lyase activity
D	0019877	biological_process	diaminopimelate biosynthetic process
D	0044281	biological_process	small molecule metabolic process
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0008700	molecular_function	4-hydroxy-2-oxoglutarate aldolase activity
E	0008840	molecular_function	4-hydroxy-tetrahydrodipicolinate synthase activity
E	0009085	biological_process	lysine biosynthetic process
E	0009089	biological_process	lysine biosynthetic process via diaminopimelate
E	0009436	biological_process	glyoxylate catabolic process
E	0016829	molecular_function	lyase activity
E	0019877	biological_process	diaminopimelate biosynthetic process
E	0044281	biological_process	small molecule metabolic process
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0008700	molecular_function	4-hydroxy-2-oxoglutarate aldolase activity
F	0008840	molecular_function	4-hydroxy-tetrahydrodipicolinate synthase activity
F	0009085	biological_process	lysine biosynthetic process
F	0009089	biological_process	lysine biosynthetic process via diaminopimelate
F	0009436	biological_process	glyoxylate catabolic process
F	0016829	molecular_function	lyase activity
F	0019877	biological_process	diaminopimelate biosynthetic process
F	0044281	biological_process	small molecule metabolic process
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0008700	molecular_function	4-hydroxy-2-oxoglutarate aldolase activity
G	0008840	molecular_function	4-hydroxy-tetrahydrodipicolinate synthase activity
G	0009085	biological_process	lysine biosynthetic process
G	0009089	biological_process	lysine biosynthetic process via diaminopimelate
G	0009436	biological_process	glyoxylate catabolic process
G	0016829	molecular_function	lyase activity
G	0019877	biological_process	diaminopimelate biosynthetic process
G	0044281	biological_process	small molecule metabolic process
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0008700	molecular_function	4-hydroxy-2-oxoglutarate aldolase activity
H	0008840	molecular_function	4-hydroxy-tetrahydrodipicolinate synthase activity
H	0009085	biological_process	lysine biosynthetic process
H	0009089	biological_process	lysine biosynthetic process via diaminopimelate
H	0009436	biological_process	glyoxylate catabolic process
H	0016829	molecular_function	lyase activity
H	0019877	biological_process	diaminopimelate biosynthetic process
H	0044281	biological_process	small molecule metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue GOL A 301

Chain	Residue
A	SER48
A	ALA49
A	TYR106
A	HOH441
A	HOH447
B	ASN80
B	TYR107

site_id	AC2
Number of Residues	8
Details	binding site for residue GOL B 301

Chain	Residue
B	SER48
B	ALA49
B	TYR106
B	HOH415
B	HOH509
B	HOH563
A	ASN80
A	TYR107

site_id	AC3
Number of Residues	6
Details	binding site for residue GOL C 301

Chain	Residue
C	SER48
C	ALA49
C	TYR106
C	HOH405
D	ASN80
D	TYR107

site_id	AC4
Number of Residues	4
Details	binding site for residue NA C 302

Chain	Residue
C	ALA152
C	VAL154
C	LYS155
C	ILE157

site_id	AC5
Number of Residues	6
Details	binding site for residue GOL E 301

Chain	Residue
E	SER48
E	ALA49
E	TYR106
E	HOH532
F	ASN80
F	TYR107

site_id	AC6
Number of Residues	6
Details	binding site for residue GOL F 301

Chain	Residue
E	ASN80
F	SER48
F	ALA49
F	TYR106
F	HOH403
F	HOH449

site_id	AC7
Number of Residues	4
Details	binding site for residue NA F 302

Chain	Residue
F	SER185
F	SER190
F	PHE194
F	HOH503

site_id	AC8
Number of Residues	7
Details	binding site for residue GOL G 301

Chain	Residue
G	SER48
G	ALA49
G	TYR106
G	HOH401
G	HOH504
H	ASN80
H	TYR107

site_id	AC9
Number of Residues	8
Details	binding site for residue GOL H 301

Chain	Residue
G	ASN80
G	TYR107
H	SER48
H	ALA49
H	TYR106
H	HOH437
H	HOH444
H	HOH479

Functional Information from PROSITE/UniProt

site_id	PS00665
Number of Residues	18
Details	DHDPS_1 Dihydrodipicolinate synthase signature 1. AIVsvGTTGESatlnhdE

Chain	Residue	Details
A	ALA38-GLU55

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)