6NUR

SARS-Coronavirus NSP12 bound to NSP7 and NSP8 co-factors

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0003968	molecular_function	RNA-dependent RNA polymerase activity
A	0005524	molecular_function	ATP binding
A	0006351	biological_process	DNA-templated transcription
A	0039694	biological_process	viral RNA genome replication
B	0004197	molecular_function	cysteine-type endopeptidase activity
B	0008242	molecular_function	omega peptidase activity
B	0016740	molecular_function	transferase activity
C	0004197	molecular_function	cysteine-type endopeptidase activity
C	0008242	molecular_function	omega peptidase activity
C	0016740	molecular_function	transferase activity
D	0004197	molecular_function	cysteine-type endopeptidase activity
D	0008242	molecular_function	omega peptidase activity
D	0016740	molecular_function	transferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 1001

Chain	Residue
A	HIS295
A	CYS301
A	CYS306
A	CYS310

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 1002

Chain	Residue
A	CYS487
A	HIS642
A	CYS645
A	CYS646

---

Functional Information from PROSITE/UniProt

site_id	PS00213
Number of Residues	12
Details	LIPOCALIN Lipocalin signature. GTS..KFYGGWHNM

Chain	Residue	Details
A	GLY590-MET601

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	SITE: Cleavage; by 3CL-PRO => ECO:0000269|PubMed:14561748, ECO:0000269|PubMed:32083638

Chain	Residue	Details
C	GLN83
D	GLN198
A	ASP761

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P0DTD1

Chain	Residue	Details
A	ASN209
A	ASP218

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01344

Chain	Residue	Details
A	HIS295
A	CYS301
A	CYS306
A	CYS310

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01293

Chain	Residue	Details
A	CYS487
A	HIS642
A	CYS645
A	CYS646

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues
Details	M-CSA 830

Chain

Residue

Details

---