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6MM8

Catalytic subunit of cAMP-dependent protein kinase A in complex with RyR2 K2879A, S2813D phosphomimetic (2699-2904) crystal form 2

Functional Information from GO Data
ChainGOidnamespacecontents
C0000122biological_processnegative regulation of transcription by RNA polymerase II
C0000287molecular_functionmagnesium ion binding
C0001669cellular_componentacrosomal vesicle
C0001707biological_processmesoderm formation
C0001843biological_processneural tube closure
C0004672molecular_functionprotein kinase activity
C0004674molecular_functionprotein serine/threonine kinase activity
C0004679molecular_functionAMP-activated protein kinase activity
C0004691molecular_functioncAMP-dependent protein kinase activity
C0004712molecular_functionprotein serine/threonine/tyrosine kinase activity
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005813cellular_componentcentrosome
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0005930cellular_componentaxoneme
C0005952cellular_componentcAMP-dependent protein kinase complex
C0006397biological_processmRNA processing
C0006468biological_processprotein phosphorylation
C0006611biological_processprotein export from nucleus
C0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
C0008284biological_processpositive regulation of cell population proliferation
C0010737biological_processprotein kinase A signaling
C0016607cellular_componentnuclear speck
C0018105biological_processpeptidyl-serine phosphorylation
C0019901molecular_functionprotein kinase binding
C0019904molecular_functionprotein domain specific binding
C0030145molecular_functionmanganese ion binding
C0031267molecular_functionsmall GTPase binding
C0031410cellular_componentcytoplasmic vesicle
C0031514cellular_componentmotile cilium
C0031594cellular_componentneuromuscular junction
C0031625molecular_functionubiquitin protein ligase binding
C0032024biological_processpositive regulation of insulin secretion
C0032991cellular_componentprotein-containing complex
C0034237molecular_functionprotein kinase A regulatory subunit binding
C0034605biological_processcellular response to heat
C0036126cellular_componentsperm flagellum
C0043197cellular_componentdendritic spine
C0043457biological_processregulation of cellular respiration
C0044853cellular_componentplasma membrane raft
C0044877molecular_functionprotein-containing complex binding
C0045667biological_processregulation of osteoblast differentiation
C0045722biological_processpositive regulation of gluconeogenesis
C0045879biological_processnegative regulation of smoothened signaling pathway
C0046827biological_processpositive regulation of protein export from nucleus
C0048240biological_processsperm capacitation
C0048471cellular_componentperinuclear region of cytoplasm
C0048792biological_processspontaneous exocytosis of neurotransmitter
C0050804biological_processmodulation of chemical synaptic transmission
C0051447biological_processnegative regulation of meiotic cell cycle
C0051726biological_processregulation of cell cycle
C0051966biological_processregulation of synaptic transmission, glutamatergic
C0061136biological_processregulation of proteasomal protein catabolic process
C0070417biological_processcellular response to cold
C0070613biological_processregulation of protein processing
C0071333biological_processcellular response to glucose stimulus
C0071374biological_processcellular response to parathyroid hormone stimulus
C0071377biological_processcellular response to glucagon stimulus
C0097546cellular_componentciliary base
C0098793cellular_componentpresynapse
C0098794cellular_componentpostsynapse
C0098978cellular_componentglutamatergic synapse
C0099170biological_processpostsynaptic modulation of chemical synaptic transmission
C0106310molecular_functionprotein serine kinase activity
C1904262biological_processnegative regulation of TORC1 signaling
C1904539biological_processnegative regulation of glycolytic process through fructose-6-phosphate
C1990044biological_processprotein localization to lipid droplet
C2000810biological_processregulation of bicellular tight junction assembly
D0006816biological_processcalcium ion transport
Functional Information from PDB Data
site_idAC1
Number of Residues9
Detailsbinding site for residue PEG C 401
ChainResidue
CASN99
CPHE100
CPRO101
CARG308
CHOH503
CHOH645
DSER2861
DLYS2862
DHOH3120

site_idAC2
Number of Residues7
Detailsbinding site for residue ACY C 402
ChainResidue
CILE135
CARG137
CPHE138
CSER139
CHIS142
CEDO404
DTRP2784

site_idAC3
Number of Residues13
Detailsbinding site for residue ANP C 403
ChainResidue
CGLY52
CSER53
CVAL57
CALA70
CLYS72
CGLU121
CVAL123
CGLU127
CHOH518
CHOH535
CHOH637
CHOH727
DARG2804

site_idAC4
Number of Residues6
Detailsbinding site for residue EDO C 404
ChainResidue
CHIS131
CHIS142
CTYR146
CPHE314
CACY402
CHOH507

site_idAC5
Number of Residues6
Detailsbinding site for residue EDO C 405
ChainResidue
CLYS72
CGLU91
CLEU95
CVAL104
CTHR183
CHOH614

site_idAC6
Number of Residues4
Detailsbinding site for residue EDO C 406
ChainResidue
CASN36
CALA38
CGLN42
CHOH597

site_idAC7
Number of Residues4
Detailsbinding site for residue EDO C 407
ChainResidue
CALA298
CTHR299
CTHR300
CHOH608

site_idAC8
Number of Residues5
Detailsbinding site for residue ACY D 3001
ChainResidue
DTHR2711
DILE2712
DLYS2775
DLYS2779
DHOH3255

site_idAC9
Number of Residues6
Detailsbinding site for residue EDO D 3002
ChainResidue
DSER2727
DPRO2773
DILE2774
DHOH3114
DHOH3143
DHOH3160

site_idAD1
Number of Residues4
Detailsbinding site for residue CL D 3003
ChainResidue
CGLU140
DTRP2786
DMET2842
DARG2904

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues24
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGTGSFGRVMlVkhkesgnh..........YAMK
ChainResidueDetails
CLEU49-LYS72

site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. LiYrDLKpeNLLI
ChainResidueDetails
CLEU162-ILE174

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:21183079
ChainResidueDetails
DSER2796
DSER2810

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphoserine; by CaMK2D and PKA => ECO:0000269|PubMed:20431056, ECO:0000269|PubMed:21098440, ECO:0007744|PubMed:21183079
ChainResidueDetails
DSER2807
CLYS72
CGLU121
CLYS168

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine; by CaMK2D => ECO:0000269|PubMed:21098440, ECO:0007744|PubMed:21183079
ChainResidueDetails
DASP2813
CTHR195

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:22323819, ECO:0000305|PubMed:8395513
ChainResidueDetails
CSER139

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphothreonine; by PDPK1 => ECO:0000269|PubMed:22323819, ECO:0000269|PubMed:8395513, ECO:0000269|PubMed:9707564
ChainResidueDetails
CTPO197

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0000269|PubMed:21866565
ChainResidueDetails
CTYR330

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000305|PubMed:8395513
ChainResidueDetails
CSEP338

220113

PDB entries from 2024-05-22

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