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6MH1

CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH HU-10, A 1,4,5-Trisubstituted Imidazole Analogue

Functional Information from PDB Data
site_idAC1
Number of Residues12
Detailsbinding site for residue JQP A 201
ChainResidue
ATRP81
AHOH368
AHOH399
BJQP201
APRO82
APHE83
ALEU92
ATYR97
AMET132
AASN140
AHOH316
AHOH332

site_idAC2
Number of Residues7
Detailsbinding site for residue EDO A 202
ChainResidue
AILE100
AILE101
ALYS102
ATHR103
AASN135
BASN116
BHOH313

site_idAC3
Number of Residues5
Detailsbinding site for residue EDO A 203
ChainResidue
AASN130
ATHR134
ATYR137
AGLU154
BHOH306

site_idAC4
Number of Residues16
Detailsbinding site for residue JQP B 201
ChainResidue
AASP145
AMET149
AJQP201
BTRP81
BPRO82
BPHE83
BLEU92
BTYR97
BMET132
BCYS136
BASN140
BILE146
BHOH317
BHOH372
BHOH380
BHOH393

site_idAC5
Number of Residues5
Detailsbinding site for residue EDO B 202
ChainResidue
BILE100
BILE101
BLYS102
BTHR103
BASN135

Functional Information from PROSITE/UniProt
site_idPS00633
Number of Residues60
DetailsBROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY
ChainResidueDetails
AALA80-TYR139

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsSITE: Acetylated histone binding => ECO:0000269|PubMed:22464331
ChainResidueDetails
AASN140
BASN140

site_idSWS_FT_FI2
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
ALYS99
BLYS99

219140

PDB entries from 2024-05-01

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