6JMR
CD98hc extracellular domain bound to HBJ127 Fab and MEM-108 Fab
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0001618 | molecular_function | virus receptor activity |
| B | 0003723 | molecular_function | RNA binding |
| B | 0003725 | molecular_function | double-stranded RNA binding |
| B | 0005294 | molecular_function | neutral L-amino acid secondary active transmembrane transporter activity |
| B | 0005432 | molecular_function | calcium:sodium antiporter activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005764 | cellular_component | lysosome |
| B | 0005765 | cellular_component | lysosomal membrane |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0006816 | biological_process | calcium ion transport |
| B | 0006865 | biological_process | amino acid transport |
| B | 0009925 | cellular_component | basal plasma membrane |
| B | 0009986 | cellular_component | cell surface |
| B | 0015173 | molecular_function | aromatic amino acid transmembrane transporter activity |
| B | 0015175 | molecular_function | neutral L-amino acid transmembrane transporter activity |
| B | 0015180 | molecular_function | L-alanine transmembrane transporter activity |
| B | 0015190 | molecular_function | L-leucine transmembrane transporter activity |
| B | 0015818 | biological_process | isoleucine transport |
| B | 0015820 | biological_process | L-leucine transport |
| B | 0015821 | biological_process | methionine transport |
| B | 0015823 | biological_process | phenylalanine transport |
| B | 0015824 | biological_process | proline transport |
| B | 0015827 | biological_process | tryptophan transport |
| B | 0015828 | biological_process | tyrosine transport |
| B | 0015829 | biological_process | valine transport |
| B | 0016020 | cellular_component | membrane |
| B | 0016323 | cellular_component | basolateral plasma membrane |
| B | 0016324 | cellular_component | apical plasma membrane |
| B | 0035725 | biological_process | sodium ion transmembrane transport |
| B | 0042470 | cellular_component | melanosome |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0043025 | cellular_component | neuronal cell body |
| B | 0043330 | biological_process | response to exogenous dsRNA |
| B | 0044225 | cellular_component | apical pole of neuron |
| B | 0045202 | cellular_component | synapse |
| B | 0045296 | molecular_function | cadherin binding |
| B | 0046718 | biological_process | symbiont entry into host cell |
| B | 0046982 | molecular_function | protein heterodimerization activity |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0070161 | cellular_component | anchoring junction |
| B | 0070327 | biological_process | thyroid hormone transport |
| B | 0140272 | molecular_function | exogenous protein binding |
| B | 1902024 | biological_process | L-histidine transport |
| B | 1903801 | biological_process | L-leucine import across plasma membrane |
| B | 1904273 | biological_process | L-alanine import across plasma membrane |
| B | 1990184 | cellular_component | amino acid transport complex |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH |
| Chain | Residue | Details |
| D | TYR198-HIS204 | |
| F | TYR197-HIS203 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 82 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:11121428, ECO:0000269|PubMed:30867591 |
| Chain | Residue | Details |
| B | MET102-ALA184 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Signal-anchor for type II membrane protein => ECO:0000269|PubMed:30867591 |
| Chain | Residue | Details |
| B | LEU185-VAL205 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 424 |
| Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:11121428, ECO:0000269|PubMed:30867591 |
| Chain | Residue | Details |
| B | ARG206-ALA630 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| B | SER103 | |
| B | SER134 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q794F9 |
| Chain | Residue | Details |
| B | THR106 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| B | SER165 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 5 |
| Details | MOD_RES: Phosphoserine => ECO:0000305|PubMed:19065266 |
| Chain | Residue | Details |
| B | SER408 | |
| B | SER410 | |
| B | SER527 | |
| B | SER531 | |
| B | SER406 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12754519, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19349973, ECO:0000269|PubMed:30867591, ECO:0000269|PubMed:33298890, ECO:0000269|PubMed:33758168, ECO:0000269|PubMed:34880232, ECO:0000269|PubMed:35352032, ECO:0007744|PDB:6IRS, ECO:0007744|PDB:7CMI, ECO:0007744|PDB:7DSK, ECO:0007744|PDB:7EPZ, ECO:0007744|PDB:7P9V |
| Chain | Residue | Details |
| B | ASN365 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12754519, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19349973, ECO:0000269|PubMed:30867591, ECO:0000269|PubMed:33298890, ECO:0000269|PubMed:33758168, ECO:0000269|PubMed:34880232, ECO:0000269|PubMed:35352032, ECO:0007744|PDB:6IRS, ECO:0007744|PDB:7CMI, ECO:0007744|PDB:7DSK, ECO:0007744|PDB:7EPZ, ECO:0007744|PDB:7P9V |
| Chain | Residue | Details |
| B | ASN381 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:12754519, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19349973, ECO:0000269|PubMed:30867591, ECO:0000269|PubMed:33298890, ECO:0000269|PubMed:33758168, ECO:0000269|PubMed:34880232, ECO:0000269|PubMed:35352032, ECO:0007744|PDB:6IRS, ECO:0007744|PDB:7CMI, ECO:0007744|PDB:7DSK, ECO:0007744|PDB:7EPZ, ECO:0007744|PDB:7P9V |
| Chain | Residue | Details |
| B | ASN424 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19349973, ECO:0000269|PubMed:30867591, ECO:0000269|PubMed:33298890, ECO:0000269|PubMed:33758168, ECO:0000269|PubMed:34880232, ECO:0000269|PubMed:35352032, ECO:0007744|PDB:6IRS, ECO:0007744|PDB:7CMH, ECO:0007744|PDB:7DSK, ECO:0007744|PDB:7EPZ, ECO:0007744|PDB:7P9V |
| Chain | Residue | Details |
| B | ASN506 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) |
| Chain | Residue | Details |
| B | LYS147 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25114211 |
| Chain | Residue | Details |
| B | LYS166 |
