6J6I

Reconstitution and structure of a plant NLR resistosome conferring immunity

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005886	cellular_component	plasma membrane
A	0006468	biological_process	protein phosphorylation
A	0006952	biological_process	defense response
A	0009507	cellular_component	chloroplast
A	0030957	molecular_function	Tat protein binding
A	0106310	molecular_function	protein serine kinase activity
A	1900426	biological_process	positive regulation of defense response to bacterium
B	0004672	molecular_function	protein kinase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation
B	0006952	biological_process	defense response
B	0007166	biological_process	cell surface receptor signaling pathway
B	0009266	biological_process	response to temperature stimulus
B	0016301	molecular_function	kinase activity
B	0042742	biological_process	defense response to bacterium
B	1900426	biological_process	positive regulation of defense response to bacterium
C	0000166	molecular_function	nucleotide binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005886	cellular_component	plasma membrane
C	0006952	biological_process	defense response
C	0042742	biological_process	defense response to bacterium
C	0043531	molecular_function	ADP binding
C	0043621	molecular_function	obsolete protein self-association
C	0050776	biological_process	regulation of immune response
C	0050829	biological_process	defense response to Gram-negative bacterium
C	0051707	biological_process	response to other organism
F	0000166	molecular_function	nucleotide binding
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005886	cellular_component	plasma membrane
F	0006952	biological_process	defense response
F	0042742	biological_process	defense response to bacterium
F	0043531	molecular_function	ADP binding
F	0043621	molecular_function	obsolete protein self-association
F	0050776	biological_process	regulation of immune response
F	0050829	biological_process	defense response to Gram-negative bacterium
F	0051707	biological_process	response to other organism
G	0000166	molecular_function	nucleotide binding
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005886	cellular_component	plasma membrane
G	0006952	biological_process	defense response
G	0042742	biological_process	defense response to bacterium
G	0043531	molecular_function	ADP binding
G	0043621	molecular_function	obsolete protein self-association
G	0050776	biological_process	regulation of immune response
G	0050829	biological_process	defense response to Gram-negative bacterium
G	0051707	biological_process	response to other organism
L	0000166	molecular_function	nucleotide binding
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005886	cellular_component	plasma membrane
L	0006952	biological_process	defense response
L	0042742	biological_process	defense response to bacterium
L	0043531	molecular_function	ADP binding
L	0043621	molecular_function	obsolete protein self-association
L	0050776	biological_process	regulation of immune response
L	0050829	biological_process	defense response to Gram-negative bacterium
L	0051707	biological_process	response to other organism
O	0000166	molecular_function	nucleotide binding
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005886	cellular_component	plasma membrane
O	0006952	biological_process	defense response
O	0042742	biological_process	defense response to bacterium
O	0043531	molecular_function	ADP binding
O	0043621	molecular_function	obsolete protein self-association
O	0050776	biological_process	regulation of immune response
O	0050829	biological_process	defense response to Gram-negative bacterium
O	0051707	biological_process	response to other organism

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	33
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGGFGCVFkGwidqtsltasrpgsgiv.VAVK

Chain	Residue	Details
A	LEU92-LYS124

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ViYrDFKaaNILL

Chain	Residue	Details
A	VAL215-LEU227

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	BINDING: BINDING => ECO:0000269|PubMed:30948527, ECO:0007744|PDB:6J5T, ECO:0007744|PDB:6J6I

Chain	Residue	Details
G	ARG297
L	ARG149
L	ARG297
O	ARG149
O	ARG297
C	ARG149
C	ARG297
F	ARG149
F	ARG297
G	ARG149

---

site_id	SWS_FT_FI2
Number of Residues	10
Details	BINDING: BINDING => ECO:0000269|PubMed:30948526, ECO:0000269|PubMed:30948527, ECO:0007744|PDB:6J5T, ECO:0007744|PDB:6J5W, ECO:0007744|PDB:6J6I

Chain	Residue	Details
F	VAL161
F	GLY189
G	VAL161
G	GLY189
L	VAL161
L	GLY189
O	VAL161
O	GLY189
C	VAL161
C	GLY189

---

site_id	SWS_FT_FI3
Number of Residues	5
Details	BINDING: BINDING => ECO:0000269|PubMed:30948526, ECO:0007744|PDB:6J5W

Chain	Residue	Details
C	LYS363
F	LYS363
G	LYS363
L	LYS363
O	LYS363

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:O48814

Chain	Residue	Details
A	THR75
A	THR254
A	THR259

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:O48814

Chain	Residue	Details
A	TYR169
A	TYR267

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:O48814

Chain	Residue	Details
A	SER253

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	LIPID: N-myristoyl glycine => ECO:0000305|PubMed:21219905

Chain	Residue	Details
A	GLY2

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	LIPID: S-palmitoyl cysteine => ECO:0000250|UniProtKB:Q9FE20

Chain	Residue	Details
A	CYS4

---