Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6J5T

Reconstitution and structure of a plant NLR resistosome conferring immunity

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005886	cellular_component	plasma membrane
A	0006468	biological_process	protein phosphorylation
A	0006952	biological_process	defense response
A	0009507	cellular_component	chloroplast
A	0030957	molecular_function	Tat protein binding
A	0106310	molecular_function	protein serine kinase activity
A	1900426	biological_process	positive regulation of defense response to bacterium
B	0004672	molecular_function	protein kinase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation
B	0006952	biological_process	defense response
B	0007166	biological_process	cell surface receptor signaling pathway
B	0009266	biological_process	response to temperature stimulus
B	0016301	molecular_function	kinase activity
B	0042742	biological_process	defense response to bacterium
B	1900426	biological_process	positive regulation of defense response to bacterium
C	0000166	molecular_function	nucleotide binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005886	cellular_component	plasma membrane
C	0006952	biological_process	defense response
C	0042742	biological_process	defense response to bacterium
C	0043531	molecular_function	ADP binding
C	0043621	molecular_function	obsolete protein self-association
C	0050776	biological_process	regulation of immune response
C	0050829	biological_process	defense response to Gram-negative bacterium
C	0051707	biological_process	response to other organism
D	0004672	molecular_function	protein kinase activity
D	0004674	molecular_function	protein serine/threonine kinase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005634	cellular_component	nucleus
D	0005886	cellular_component	plasma membrane
D	0006468	biological_process	protein phosphorylation
D	0006952	biological_process	defense response
D	0009507	cellular_component	chloroplast
D	0030957	molecular_function	Tat protein binding
D	0106310	molecular_function	protein serine kinase activity
D	1900426	biological_process	positive regulation of defense response to bacterium
E	0004672	molecular_function	protein kinase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0006468	biological_process	protein phosphorylation
E	0006952	biological_process	defense response
E	0007166	biological_process	cell surface receptor signaling pathway
E	0009266	biological_process	response to temperature stimulus
E	0016301	molecular_function	kinase activity
E	0042742	biological_process	defense response to bacterium
E	1900426	biological_process	positive regulation of defense response to bacterium
F	0000166	molecular_function	nucleotide binding
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005886	cellular_component	plasma membrane
F	0006952	biological_process	defense response
F	0042742	biological_process	defense response to bacterium
F	0043531	molecular_function	ADP binding
F	0043621	molecular_function	obsolete protein self-association
F	0050776	biological_process	regulation of immune response
F	0050829	biological_process	defense response to Gram-negative bacterium
F	0051707	biological_process	response to other organism
G	0000166	molecular_function	nucleotide binding
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005886	cellular_component	plasma membrane
G	0006952	biological_process	defense response
G	0042742	biological_process	defense response to bacterium
G	0043531	molecular_function	ADP binding
G	0043621	molecular_function	obsolete protein self-association
G	0050776	biological_process	regulation of immune response
G	0050829	biological_process	defense response to Gram-negative bacterium
G	0051707	biological_process	response to other organism
H	0004672	molecular_function	protein kinase activity
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0006468	biological_process	protein phosphorylation
H	0006952	biological_process	defense response
H	0007166	biological_process	cell surface receptor signaling pathway
H	0009266	biological_process	response to temperature stimulus
H	0016301	molecular_function	kinase activity
H	0042742	biological_process	defense response to bacterium
H	1900426	biological_process	positive regulation of defense response to bacterium
I	0004672	molecular_function	protein kinase activity
I	0004674	molecular_function	protein serine/threonine kinase activity
I	0005515	molecular_function	protein binding
I	0005524	molecular_function	ATP binding
I	0005634	cellular_component	nucleus
I	0005886	cellular_component	plasma membrane
I	0006468	biological_process	protein phosphorylation
I	0006952	biological_process	defense response
I	0009507	cellular_component	chloroplast
I	0030957	molecular_function	Tat protein binding
I	0106310	molecular_function	protein serine kinase activity
I	1900426	biological_process	positive regulation of defense response to bacterium
J	0004672	molecular_function	protein kinase activity
J	0004674	molecular_function	protein serine/threonine kinase activity
J	0005515	molecular_function	protein binding
J	0005524	molecular_function	ATP binding
J	0005634	cellular_component	nucleus
J	0005886	cellular_component	plasma membrane
J	0006468	biological_process	protein phosphorylation
J	0006952	biological_process	defense response
J	0009507	cellular_component	chloroplast
J	0030957	molecular_function	Tat protein binding
J	0106310	molecular_function	protein serine kinase activity
J	1900426	biological_process	positive regulation of defense response to bacterium
K	0004672	molecular_function	protein kinase activity
K	0005515	molecular_function	protein binding
K	0005524	molecular_function	ATP binding
K	0006468	biological_process	protein phosphorylation
K	0006952	biological_process	defense response
K	0007166	biological_process	cell surface receptor signaling pathway
K	0009266	biological_process	response to temperature stimulus
K	0016301	molecular_function	kinase activity
K	0042742	biological_process	defense response to bacterium
K	1900426	biological_process	positive regulation of defense response to bacterium
L	0000166	molecular_function	nucleotide binding
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005886	cellular_component	plasma membrane
L	0006952	biological_process	defense response
L	0042742	biological_process	defense response to bacterium
L	0043531	molecular_function	ADP binding
L	0043621	molecular_function	obsolete protein self-association
L	0050776	biological_process	regulation of immune response
L	0050829	biological_process	defense response to Gram-negative bacterium
L	0051707	biological_process	response to other organism
M	0004672	molecular_function	protein kinase activity
M	0004674	molecular_function	protein serine/threonine kinase activity
M	0005515	molecular_function	protein binding
M	0005524	molecular_function	ATP binding
M	0005634	cellular_component	nucleus
M	0005886	cellular_component	plasma membrane
M	0006468	biological_process	protein phosphorylation
M	0006952	biological_process	defense response
M	0009507	cellular_component	chloroplast
M	0030957	molecular_function	Tat protein binding
M	0106310	molecular_function	protein serine kinase activity
M	1900426	biological_process	positive regulation of defense response to bacterium
N	0004672	molecular_function	protein kinase activity
N	0005515	molecular_function	protein binding
N	0005524	molecular_function	ATP binding
N	0006468	biological_process	protein phosphorylation
N	0006952	biological_process	defense response
N	0007166	biological_process	cell surface receptor signaling pathway
N	0009266	biological_process	response to temperature stimulus
N	0016301	molecular_function	kinase activity
N	0042742	biological_process	defense response to bacterium
N	1900426	biological_process	positive regulation of defense response to bacterium
O	0000166	molecular_function	nucleotide binding
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005886	cellular_component	plasma membrane
O	0006952	biological_process	defense response
O	0042742	biological_process	defense response to bacterium
O	0043531	molecular_function	ADP binding
O	0043621	molecular_function	obsolete protein self-association
O	0050776	biological_process	regulation of immune response
O	0050829	biological_process	defense response to Gram-negative bacterium
O	0051707	biological_process	response to other organism

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	33
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGGFGCVFkGwidqtsltasrpgsgiv.VAVK

Chain	Residue	Details
I	LEU92-LYS124

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ViYrDFKaaNILL

Chain	Residue	Details
I	VAL215-LEU227

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	5
Details	ACT_SITE: Proton acceptor => ECO:0000255\|PROSITE-ProRule:PRU00159

Chain	Residue	Details
I	ASP219
A	ASP219
D	ASP219
J	ASP219
M	ASP219
F	ARG297
L	ARG149
L	ARG297
O	ARG149
O	ARG297

site_id	SWS_FT_FI2
Number of Residues	5
Details	BINDING: BINDING => ECO:0000255\|PROSITE-ProRule:PRU00159, ECO:0000269\|PubMed:30948526, ECO:0000269\|PubMed:30948527, ECO:0007744\|PDB:6J5T, ECO:0007744\|PDB:6J5U, ECO:0007744\|PDB:6J5V, ECO:0007744\|PDB:6J6I

Chain	Residue	Details
D	LEU92
J	LEU92
M	LEU92
E	LYS87
K	VAL66
K	LYS87
N	VAL66
N	LYS87
I	LEU92
A	LEU92

site_id	SWS_FT_FI3
Number of Residues	5
Details	BINDING: BINDING => ECO:0000255\|PROSITE-ProRule:PRU00159

Chain	Residue	Details
I	LYS124
A	LYS124
D	LYS124
J	LYS124
M	LYS124

site_id	SWS_FT_FI4
Number of Residues	15
Details	MOD_RES: Phosphothreonine => ECO:0000250\|UniProtKB:O48814

Chain	Residue	Details
I	THR261
A	THR75
A	THR254
I	THR75
I	THR254
A	THR261
D	THR75
D	THR254
D	THR261
J	THR75
J	THR254
J	THR261
M	THR75
M	THR254
M	THR261

site_id	SWS_FT_FI5
Number of Residues	10
Details	MOD_RES: Phosphotyrosine => ECO:0000250\|UniProtKB:O48814

Chain	Residue	Details
I	TYR169
I	TYR269
A	TYR169
A	TYR269
D	TYR169
D	TYR269
J	TYR169
J	TYR269
M	TYR169
M	TYR269

site_id	SWS_FT_FI6
Number of Residues	5
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:O48814

Chain	Residue	Details
I	SER253
A	SER253
D	SER253
J	SER253
M	SER253

site_id	SWS_FT_FI7
Number of Residues	5
Details	LIPID: N-myristoyl glycine => ECO:0000305\|PubMed:21219905

Chain	Residue	Details
I	GLY2
A	GLY2
D	GLY2
J	GLY2
M	GLY2

site_id	SWS_FT_FI8
Number of Residues	5
Details	LIPID: S-palmitoyl cysteine => ECO:0000250\|UniProtKB:Q9FE20

Chain	Residue	Details
I	CYS4
A	CYS4
D	CYS4
J	CYS4
M	CYS4

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)