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6J5I

Cryo-EM structure of the mammalian DP-state ATP synthase

Functional Information from GO Data
ChainGOidnamespacecontents
80000276cellular_componentmitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
80005739cellular_componentmitochondrion
80005753cellular_componentmitochondrial proton-transporting ATP synthase complex
80006754biological_processATP biosynthetic process
80015078molecular_functionproton transmembrane transporter activity
80015986biological_processproton motive force-driven ATP synthesis
80016020cellular_componentmembrane
80031966cellular_componentmitochondrial membrane
80045263cellular_componentproton-transporting ATP synthase complex, coupling factor F(o)
81902600biological_processproton transmembrane transport
A0005524molecular_functionATP binding
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005743cellular_componentmitochondrial inner membrane
A0005754cellular_componentmitochondrial proton-transporting ATP synthase, catalytic core
A0005886cellular_componentplasma membrane
A0006754biological_processATP biosynthetic process
A0015986biological_processproton motive force-driven ATP synthesis
A0032559molecular_functionadenyl ribonucleotide binding
A0043531molecular_functionADP binding
A0045261cellular_componentproton-transporting ATP synthase complex, catalytic core F(1)
A0046034biological_processATP metabolic process
A0046933molecular_functionproton-transporting ATP synthase activity, rotational mechanism
A1902600biological_processproton transmembrane transport
B0005524molecular_functionATP binding
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005743cellular_componentmitochondrial inner membrane
B0005754cellular_componentmitochondrial proton-transporting ATP synthase, catalytic core
B0005886cellular_componentplasma membrane
B0006754biological_processATP biosynthetic process
B0015986biological_processproton motive force-driven ATP synthesis
B0032559molecular_functionadenyl ribonucleotide binding
B0043531molecular_functionADP binding
B0045261cellular_componentproton-transporting ATP synthase complex, catalytic core F(1)
B0046034biological_processATP metabolic process
B0046933molecular_functionproton-transporting ATP synthase activity, rotational mechanism
B1902600biological_processproton transmembrane transport
C0005524molecular_functionATP binding
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005743cellular_componentmitochondrial inner membrane
C0005754cellular_componentmitochondrial proton-transporting ATP synthase, catalytic core
C0005886cellular_componentplasma membrane
C0006754biological_processATP biosynthetic process
C0015986biological_processproton motive force-driven ATP synthesis
C0032559molecular_functionadenyl ribonucleotide binding
C0043531molecular_functionADP binding
C0045261cellular_componentproton-transporting ATP synthase complex, catalytic core F(1)
C0046034biological_processATP metabolic process
C0046933molecular_functionproton-transporting ATP synthase activity, rotational mechanism
C1902600biological_processproton transmembrane transport
D0005524molecular_functionATP binding
D0015986biological_processproton motive force-driven ATP synthesis
D0016887molecular_functionATP hydrolysis activity
D0045261cellular_componentproton-transporting ATP synthase complex, catalytic core F(1)
D0046034biological_processATP metabolic process
D0046933molecular_functionproton-transporting ATP synthase activity, rotational mechanism
D1902600biological_processproton transmembrane transport
E0005524molecular_functionATP binding
E0015986biological_processproton motive force-driven ATP synthesis
E0016887molecular_functionATP hydrolysis activity
E0045261cellular_componentproton-transporting ATP synthase complex, catalytic core F(1)
E0046034biological_processATP metabolic process
E0046933molecular_functionproton-transporting ATP synthase activity, rotational mechanism
E1902600biological_processproton transmembrane transport
F0005524molecular_functionATP binding
F0015986biological_processproton motive force-driven ATP synthesis
F0016887molecular_functionATP hydrolysis activity
F0045261cellular_componentproton-transporting ATP synthase complex, catalytic core F(1)
F0046034biological_processATP metabolic process
F0046933molecular_functionproton-transporting ATP synthase activity, rotational mechanism
F1902600biological_processproton transmembrane transport
G0015986biological_processproton motive force-driven ATP synthesis
G0045261cellular_componentproton-transporting ATP synthase complex, catalytic core F(1)
G0046933molecular_functionproton-transporting ATP synthase activity, rotational mechanism
H0015986biological_processproton motive force-driven ATP synthesis
H0045261cellular_componentproton-transporting ATP synthase complex, catalytic core F(1)
H0046933molecular_functionproton-transporting ATP synthase activity, rotational mechanism
I0000275cellular_componentmitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)
I0005743cellular_componentmitochondrial inner membrane
I0015986biological_processproton motive force-driven ATP synthesis
I0042776biological_processproton motive force-driven mitochondrial ATP synthesis
I0045261cellular_componentproton-transporting ATP synthase complex, catalytic core F(1)
I0046933molecular_functionproton-transporting ATP synthase activity, rotational mechanism
J0005739cellular_componentmitochondrion
J0032780biological_processnegative regulation of ATP-dependent activity
J0042030molecular_functionATPase inhibitor activity
K0015078molecular_functionproton transmembrane transporter activity
K0015986biological_processproton motive force-driven ATP synthesis
K0033177cellular_componentproton-transporting two-sector ATPase complex, proton-transporting domain
K0045263cellular_componentproton-transporting ATP synthase complex, coupling factor F(o)
K1902600biological_processproton transmembrane transport
L0015078molecular_functionproton transmembrane transporter activity
L0015986biological_processproton motive force-driven ATP synthesis
L0033177cellular_componentproton-transporting two-sector ATPase complex, proton-transporting domain
L0045263cellular_componentproton-transporting ATP synthase complex, coupling factor F(o)
L1902600biological_processproton transmembrane transport
M0015078molecular_functionproton transmembrane transporter activity
M0015986biological_processproton motive force-driven ATP synthesis
M0033177cellular_componentproton-transporting two-sector ATPase complex, proton-transporting domain
M0045263cellular_componentproton-transporting ATP synthase complex, coupling factor F(o)
M1902600biological_processproton transmembrane transport
N0015078molecular_functionproton transmembrane transporter activity
N0015986biological_processproton motive force-driven ATP synthesis
N0033177cellular_componentproton-transporting two-sector ATPase complex, proton-transporting domain
N0045263cellular_componentproton-transporting ATP synthase complex, coupling factor F(o)
N1902600biological_processproton transmembrane transport
O0015078molecular_functionproton transmembrane transporter activity
O0015986biological_processproton motive force-driven ATP synthesis
O0033177cellular_componentproton-transporting two-sector ATPase complex, proton-transporting domain
O0045263cellular_componentproton-transporting ATP synthase complex, coupling factor F(o)
O1902600biological_processproton transmembrane transport
P0015078molecular_functionproton transmembrane transporter activity
P0015986biological_processproton motive force-driven ATP synthesis
P0033177cellular_componentproton-transporting two-sector ATPase complex, proton-transporting domain
P0045263cellular_componentproton-transporting ATP synthase complex, coupling factor F(o)
P1902600biological_processproton transmembrane transport
Q0015078molecular_functionproton transmembrane transporter activity
Q0015986biological_processproton motive force-driven ATP synthesis
Q0033177cellular_componentproton-transporting two-sector ATPase complex, proton-transporting domain
Q0045263cellular_componentproton-transporting ATP synthase complex, coupling factor F(o)
Q1902600biological_processproton transmembrane transport
R0015078molecular_functionproton transmembrane transporter activity
R0015986biological_processproton motive force-driven ATP synthesis
R0033177cellular_componentproton-transporting two-sector ATPase complex, proton-transporting domain
R0045263cellular_componentproton-transporting ATP synthase complex, coupling factor F(o)
R1902600biological_processproton transmembrane transport
S0015986biological_processproton motive force-driven ATP synthesis
S0016020cellular_componentmembrane
S0046933molecular_functionproton-transporting ATP synthase activity, rotational mechanism
a0005739cellular_componentmitochondrion
a0005743cellular_componentmitochondrial inner membrane
a0005753cellular_componentmitochondrial proton-transporting ATP synthase complex
a0006754biological_processATP biosynthetic process
a0015078molecular_functionproton transmembrane transporter activity
a0015986biological_processproton motive force-driven ATP synthesis
a0045263cellular_componentproton-transporting ATP synthase complex, coupling factor F(o)
a0046933molecular_functionproton-transporting ATP synthase activity, rotational mechanism
a1902600biological_processproton transmembrane transport
b0000276cellular_componentmitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
b0015078molecular_functionproton transmembrane transporter activity
b0015986biological_processproton motive force-driven ATP synthesis
c0000276cellular_componentmitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
c0005739cellular_componentmitochondrion
c0005743cellular_componentmitochondrial inner membrane
c0005753cellular_componentmitochondrial proton-transporting ATP synthase complex
c0015078molecular_functionproton transmembrane transporter activity
c0015986biological_processproton motive force-driven ATP synthesis
c0045263cellular_componentproton-transporting ATP synthase complex, coupling factor F(o)
c1902600biological_processproton transmembrane transport
d0000276cellular_componentmitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
d0015078molecular_functionproton transmembrane transporter activity
d0015986biological_processproton motive force-driven ATP synthesis
f0005739cellular_componentmitochondrion
f0005743cellular_componentmitochondrial inner membrane
f0005753cellular_componentmitochondrial proton-transporting ATP synthase complex
f0006754biological_processATP biosynthetic process
f0042776biological_processproton motive force-driven mitochondrial ATP synthesis
f0045263cellular_componentproton-transporting ATP synthase complex, coupling factor F(o)
f0046933molecular_functionproton-transporting ATP synthase activity, rotational mechanism
f1902600biological_processproton transmembrane transport
i0005753cellular_componentmitochondrial proton-transporting ATP synthase complex
Functional Information from PDB Data
site_idAC1
Number of Residues11
Detailsbinding site for residue ATP A 601
ChainResidue
AGLN172
AMG602
DARG358
ATHR173
AGLY174
ALYS175
ATHR176
ASER177
APRO363
AGLN430
AGLN432

site_idAC2
Number of Residues2
Detailsbinding site for residue MG A 602
ChainResidue
ATHR176
AATP601

site_idAC3
Number of Residues12
Detailsbinding site for residue ATP B 601
ChainResidue
BARG171
BGLN172
BGLY174
BLYS175
BTHR176
BSER177
BGLU328
BGLN430
BGLN432
BMG602
EARG358
EASP361

site_idAC4
Number of Residues4
Detailsbinding site for residue MG B 602
ChainResidue
BTHR176
BGLN208
BASP269
BATP601

site_idAC5
Number of Residues14
Detailsbinding site for residue ATP C 601
ChainResidue
CARG171
CGLN172
CTHR173
CGLY174
CLYS175
CTHR176
CSER177
CPHE357
CARG362
CGLY431
CGLN432
CMG602
FSER357
FARG374

site_idAC6
Number of Residues3
Detailsbinding site for residue MG C 602
ChainResidue
CTHR176
CASP269
CATP601

site_idAC7
Number of Residues10
Detailsbinding site for residue ADP D 501
ChainResidue
CARG373
DGLY161
DVAL162
DGLY163
DLYS164
DTHR165
DTYR347
DALA423
DPHE426
DMG502

site_idAC8
Number of Residues3
Detailsbinding site for residue MG D 502
ChainResidue
DTHR165
DGLU194
DADP501

site_idAC9
Number of Residues9
Detailsbinding site for residue ADP F 501
ChainResidue
BARG373
FGLY161
FVAL162
FGLY163
FLYS164
FTHR165
FVAL166
FPHE420
FMG502

site_idAD1
Number of Residues1
Detailsbinding site for residue MG F 502
ChainResidue
FADP501

Functional Information from PROSITE/UniProt
site_idPS00152
Number of Residues10
DetailsATPASE_ALPHA_BETA ATP synthase alpha and beta subunits signature. PAINVGLSVS
ChainResidueDetails
APRO363-SER372
DPRO348-SER357

site_idPS00449
Number of Residues10
DetailsATPASE_A ATP synthase a subunit signature. ALAVRLTANI
ChainResidueDetails
aALA155-ILE164

site_idPS00153
Number of Residues14
DetailsATPASE_GAMMA ATP synthase gamma subunit signature. ITkEliEiisGAaA
ChainResidueDetails
GILE258-ALA271

site_idPS00389
Number of Residues20
DetailsATPASE_DELTA ATP synthase delta (OSCP) subunit signature. LkLevkVDpSImGGMIVRiG
ChainResidueDetails
SLEU148-GLY167

site_idPS00605
Number of Residues22
DetailsATPASE_C ATP synthase c subunit signature. ARNPslkqqLfSyaILgfaLsE
ChainResidueDetails
PALA37-GLU58

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues120
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
aPHE6-PHE26
aTRP68-LEU88
aGLN97-PHE117
aLEU136-LEU156
aILE164-ILE184
aALA189-ILE209

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P03930
ChainResidueDetails
8LYS54
SLYS176
CSER370

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P03930
ChainResidueDetails
cLYS67
ASER141
BSER10
CSER22
CSER123
CSER141
8LYS57
SLYS139
BSER22
BSER123
BSER141
CSER10

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P56135
ChainResidueDetails
fLYS15
SLYS169
CSER33

site_idSWS_FT_FI5
Number of Residues3
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q03265
ChainResidueDetails
ASER63
BSER63
CSER63

site_idSWS_FT_FI6
Number of Residues15
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q03265
ChainResidueDetails
ALYS197
ALYS498
BLYS80
BLYS83
BLYS89
BLYS197
BLYS498
CLYS80
CLYS83
CLYS89
CLYS197
CLYS498
ALYS80
ALYS83
ALYS89

site_idSWS_FT_FI7
Number of Residues3
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P15999
ChainResidueDetails
ATHR91
BTHR91
CTHR91

site_idSWS_FT_FI8
Number of Residues33
DetailsMOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q03265
ChainResidueDetails
ALYS196
ALYS218
ALYS262
ALYS384
ALYS455
ALYS463
ALYS488
ALYS496
BLYS118
BLYS124
BLYS187
BLYS196
BLYS218
BLYS262
BLYS384
BLYS455
BLYS463
BLYS488
BLYS496
CLYS118
CLYS124
CLYS187
CLYS196
CLYS218
CLYS262
CLYS384
CLYS455
CLYS463
CLYS488
CLYS496
ALYS118
ALYS124
ALYS187

site_idSWS_FT_FI9
Number of Residues3
DetailsMOD_RES: Omega-N-methylarginine => ECO:0000250|UniProtKB:Q03265
ChainResidueDetails
CARG161
AARG161
BARG161

site_idSWS_FT_FI10
Number of Residues3
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P25705
ChainResidueDetails
ALYS391
BLYS391
CLYS391

site_idSWS_FT_FI11
Number of Residues3
DetailsCARBOHYD: O-linked (GlcNAc) serine; alternate => ECO:0000250
ChainResidueDetails
ASER33
BSER33
CSER33

219869

PDB entries from 2024-05-15

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