6IWI

Crystal structure of PDE5A in complex with a novel inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
A	0007165	biological_process	signal transduction
A	0008081	molecular_function	phosphoric diester hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue MG A 900

Chain	Residue
A	ASP654
A	GLU682
A	HOH1014
A	HOH1019
A	HOH1046
A	HOH1065
A	HOH1093

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site_id	AC2
Number of Residues	6
Details	binding site for residue ZN A 901

Chain	Residue
A	ASP654
A	ASP764
A	HOH1028
A	HOH1065
A	HIS617
A	HIS653

---

site_id	AC3
Number of Residues	8
Details	binding site for residue B0C A 902

Chain	Residue
A	TYR612
A	ALA779
A	PHE786
A	GLN817
A	GLY819
A	PHE820
A	HOH1015
A	HOH1018

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Functional Information from PROSITE/UniProt

site_id	PS00126
Number of Residues	12
Details	PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDLdHrGvnNsY

Chain	Residue	Details
A	HIS653-TYR664

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton donor => ECO:0000250|UniProtKB:O76083

Chain	Residue	Details
A	HIS613

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:12955149, ECO:0000269|PubMed:15260978, ECO:0007744|PDB:1T9R, ECO:0007744|PDB:1T9S, ECO:0007744|PDB:1TBF

Chain	Residue	Details
A	ASP654
A	ASP764
A	HIS617
A	HIS653

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:12955149

Chain	Residue	Details
A	GLN817

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